2021
DOI: 10.15585/mmwr.mm7049a1
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Update on Vaccine-Derived Poliovirus Outbreaks — Worldwide, January 2020–June 2021

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Cited by 52 publications
(79 citation statements)
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“…The plan also aims to support the scale-up of nOPV2 availability ( 6 ). However, given currently limited nOPV2 supply replenishment, higher than expected demand has depleted nOPV2 stock ( 3 , 4 ). The risk for international spread of polioviruses was declared a Public Health Emergency of International Concern in 2014; in 2021, the Strategic Advisory Group of Experts on Immunization and other advisory bodies ††† , §§§ recommended that any country experiencing a cVDPV2 outbreak should begin prompt outbreak response with available OPV2 vaccine, whether it be a Sabin strain mOPV2 or nOPV2 ( 10 ).…”
Section: Discussionmentioning
confidence: 99%
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“…The plan also aims to support the scale-up of nOPV2 availability ( 6 ). However, given currently limited nOPV2 supply replenishment, higher than expected demand has depleted nOPV2 stock ( 3 , 4 ). The risk for international spread of polioviruses was declared a Public Health Emergency of International Concern in 2014; in 2021, the Strategic Advisory Group of Experts on Immunization and other advisory bodies ††† , §§§ recommended that any country experiencing a cVDPV2 outbreak should begin prompt outbreak response with available OPV2 vaccine, whether it be a Sabin strain mOPV2 or nOPV2 ( 10 ).…”
Section: Discussionmentioning
confidence: 99%
“…cVDPV type 2 (cVDPV2) has been the predominant cause of cVDPV outbreaks since 2006 and informed the rationale for the switch to bOPV. Monovalent OPV Sabin type 2 (mOPV2) is reserved for cVDPV2 outbreak response campaigns ( 3 ).…”
Section: Poliovirus Vaccinationmentioning
confidence: 99%
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“…During January 2020-November 2021, with importation of cVDPV2 from Pakistan and new emergences seeded after mOPV2 use in Afghanistan (6), 351 cVDPV2 cases were reported from 131 districts in 28 provinces; 225 (64%) of those occurred among children aged <36 months. Of the 351 cVDPV2 cases, 225 (64%) were genetically related to…”
Section: Month/yearmentioning
confidence: 99%
“…By the end of 2021, wild poliovirus (WPV) remained endemic in only two countries (Pakistan and Afghanistan). However, a WPV type 1 (WPV1) case with paralysis onset in 2021, was reported by Malawi a year after the World Health Organization (WHO) African Region (AFR) was certified as WPV-free and circulating vaccine-derived poliovirus (cVDPV) cases were reported from 31 countries during 2020–2021 ( 1 , 2 ). cVDPVs are oral poliovirus vaccine-derived viruses that can emerge after prolonged circulation in populations with low immunity and cause paralysis.…”
mentioning
confidence: 99%