Uphill Running Excessive Training Increases Gastrocnemius Glycogen Content in C57BL/6 Mice

Morais, Gustavo P.; Rocha, Aristides Almeida; Pinto, Ana P.; Oliveira, Luís Guilherme de; Vicente, Larissa G. de; Ferreira, Graziella Nascimento; Freitas, Ellen Cristini de; Silva, A. S. R. da

doi:10.33549/physiolres.933614

Cited by 5 publications

(1 citation statement)

References 58 publications

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“…Some studies were even able to show an increase in blood lactate concentration in response to the increasing slope ( Itoh et al, 1996 ; Padulo et al, 2013 ). Incline has a significant effect on the metabolism of rats running on a motor-driven treadmill ( Armstrong et al, 1983 ) and uphill training in rats has proven to increase glycogen content in the gastrocnemius muscle ( Morais et al, 2018 ) as well as enhance mitochondrial function in soleus and vastus intermedius muscles ( Schlagowski et al, 2016 ). Considering these findings, it could be hypothesized that trail runners have a lower lactate difference between a maximal uphill running test and a maximal level running test than runners used to level road races.…”

Section: Introductionmentioning

confidence: 99%

Outdoor Uphill Exercise Testing for Trail Runners, a More Suitable Method?

Schöffl¹,

Jasiński²,

Ehrlich³

et al. 2021

Journal of Human Kinetics

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There is extensive knowledge about uphill running on a treadmill, although paucity regarding the influence of uphill trail running on exercise capacity in runners. The purpose of this study was to compare an uphill field test with a treadmill test with 1% inclination especially considering cardiopulmonary exercise variables. The difference in those tests between a group of trail runners and a group of road runners was tested for establishing a test specifically for trail runners. Ten male endurance road runners and ten male trail runners performed one maximal incremental treadmill test with 1% inclination and a maximal incremental field test on a hill at 16% inclination which they were instructed to run up four times for three minutes, each time with a higher pace. A mobile cardiopulmonary exercise testing unit was used to measure ventilation. There were no significant differences between trail runners and road runners. The equivalence factor was comparable between both groups. V ˙ O 2 p e a k $\dot{V} O_{2 p e a k}$ was comparable for both test protocols. However, there was a significant difference between the two test protocols regarding lactate concentration, the respiratory exchange ratio, running cost, heart rate, Breathing reserve, and O2pulse. The greater lactate concentration and running cost recorded uphill indicate a higher energy demand during trail running than level road running.

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Section: Introductionmentioning

confidence: 99%

Outdoor Uphill Exercise Testing for Trail Runners, a More Suitable Method?

Schöffl¹,

Jasiński²,

Ehrlich³

et al. 2021

Journal of Human Kinetics

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Spatiotemporal Characterization of Microstructure Morphology, Mechanical Properties and Bone Remodeling of Rat Tibia Under Uniaxial Compressive Overload Loading

Liu,

Gao,

Gong

2024

Ann Biomed Eng

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Effect of eccentric and concentric contraction mode on myogenic regulatory factors expression in human vastus lateralis muscle

Sabouri

Taghibeikzadehbadr

Shabkhiz

et al. 2022

J Muscle Res Cell Motil

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Background: Skeletal muscle contractions are caused to release myokines by muscle ber. This study investigated the myogenic regulatory factors, as MHC I, IIA, IIX, Myo-D, MRF4, Murf, Atrogin-1, Decorin, Myonection, and IL-15 mRNA expression in the response of eccentric vs. concentric contraction.Methods: Eighteen healthy men were randomly divided into two eccentric and concentric groups, each of 9 persons. Isokinetic contraction protocols included maximal single-leg eccentric or concentric knee extension tasks at 60°/s with the dominant leg. Contractions consisted of a maximum of 12 sets of 10 reps, and the rest time between each set was 30 seconds. The baseline biopsy was performed four weeks before the study, and post-test biopsies were taken immediately after exercise protocols from Vastus Lateralis muscle. The gene expression levels evaluated using Real-Time PCR methods.Results: A signi cant difference in MyoD, MRF4, Myonection, and Decorin mRNA, were observed following eccentric or concentric contractions (P≤0.05). The MHC I, MHC IIA, IL-15 mRNA has been changed signi cantly compared to the pre-exercise in the concentric group (P≤0.05). While only MHC IIX and Atrogin-1 mRNA changed signi cantly in the eccentric group (P≤0.05). Additionally, the results showed a signi cant difference in MyoD, MRF4, IL-15, and Decorin were observed at the follow-up values between eccentric or concentric groups (P≤0.05). Conclusion: Our ndings highlight the growing importance of elucidating the different responses of muscle growth factors associated with a myogenic activity such as MHC IIA, Decorin, IL-15, Myonectin, Decorin, MuRF1, and MHC IIX mRNA in following to various types of exercise.

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Uphill Running Excessive Training Increases Gastrocnemius Glycogen Content in C57BL/6 Mice

Cited by 5 publications

References 58 publications

Outdoor Uphill Exercise Testing for Trail Runners, a More Suitable Method?

Outdoor Uphill Exercise Testing for Trail Runners, a More Suitable Method?

Spatiotemporal Characterization of Microstructure Morphology, Mechanical Properties and Bone Remodeling of Rat Tibia Under Uniaxial Compressive Overload Loading

Effect of eccentric and concentric contraction mode on myogenic regulatory factors expression in human vastus lateralis muscle

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