In this paper, we consider a discontinuous, fully nonlinear, higher-order equation on the half-line, together with functional boundary conditions, given by general continuous functions with dependence on the several derivatives and asymptotic information on the (n−1)th derivative of the unknown function. These functional conditions generalize the usual boundary data and allow other types of global assumptions on the unknown function and its derivatives, such as nonlocal, integro-differential, infinite multipoint, with maximum or minimum arguments, among others. Considering the half-line as the domain carries on a lack of compactness, which is overcome with the definition of a space of weighted functions and norms, and the equiconvergence at ∞. In the last section, an example illustrates the applicability of our main result.