Upregulation of chemokines in bronchoalveolar lavage fluid as a predictive marker of post-transplant airway obliteration

Heterogeneity of chronic lung allograft dysfunction: Insights from protein expression in broncho alveolar lavage

“…Subdividing the BOS group into NRAD and fBOS clearly attributed the differences to the NRAD group, while the fBOS group showed no difference at all. IL-8 is not the only chemo-attractant associated with BOS, MCP-1 and RANTES for example are reported to be involved (19) as is also confirmed in our results. Their main aim is to attract monocytes and to a lesser extent dendritic cells and Recently these data were confirmed in BAL as there is an elevation of HGF levels in BOS patients (26).…”

Protein Kinase Cδ Mediates Lysophosphatidic Acid-induced NF-κB Activation and Interleukin-8 Secretion in Human Bronchial Epithelial Cells

“…Increased expression and release of IL-8, a potent chemoattractant of neutrophils, have been described in bronchial epithelial cells in response to TNF-␣, IL-1, and exposure to tobacco smoke, diesel exhaust particles, ozone, viral infection, and hyperoxia (3)(4)(5)(6)(7)(8). The data presented here show for the first time enhanced expression of the IL-8 gene as well as its secretion by LPA in primary cultures of HBEpCs.…”

“…One such paracrine messenger, interleukin-8 (IL-8), 1 the major chemoattractant and activator for neutrophils in the lung, is a key component of the innate immune response (2). Studies supporting the involvement of IL-8 in pulmonary inflammatory disorders have revealed elevated levels of IL-8 in the bronchoalveolar lavage (BAL) fluid of patients with chronic obstructive lung disease, asthma, idiopathic pulmonary fibrosis, pulmonary sarcoidosis, pneumonia, bronchitis obliterans syndrome, and acute lung injury/acute respiratory distress syndrome (3)(4)(5)(6)(7)(8). Cultured airway epithelial cells also secrete significant amounts of IL-8 when exposed to tobacco smoke, diesel exhaust particles, ozone, viral infection, and hyperoxia as well as various endogenous mediators such as TNF-␣ and IL-1 (9 -14).…”

Alcohol Ingestion by Donors Amplifies Experimental Airway Disease after Heterotopic Transplantation

“…Although a variety of risk factors have been implicated in the development of OB (3), predicting which transplant recipients develop OB has been as yet unreliable. Several studies have demonstrated a correlation between the presence of a variety of biomarkers and the development of OB (4)(5)(6)(7)(8)(9)(10). Studies have shown that acute rejection is a risk factor for long-term graft dysfunction (3,11,12); however, others have failed to establish this correlation (13,14).…”