Upregulation of LncRNA FEZF-AS1 is associated with advanced clinical stages and family history of cancer in patients with NSCLC

Gong, Wei; Cao, Yi; Wang, Yuanyuan; Yang, Lei; Su, Wenpeng; Qiu, Fuman; Datta, Siraj; Rao, Boqi; Xian, Jianfeng; Lin, Mingzhu; Feng, Yingyi; Zhang, Xin; Zhou, Yifeng; Gao, Xingcheng

doi:10.1016/j.prp.2018.04.014

Cited by 15 publications

(9 citation statements)

References 26 publications

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“…The correlation analysis indicated that high FEZF1-AS1 expression was significantly correlated with present choroidal invasion and optic nerve invasion. In lung cancer patients, three clinical studies congruously showed that high FEZF1-AS1 expression was correlated with advanced clinical stage [18,19,21]. Besides, Zhang et al [22] found high FEZF1-AS1 expression was related with advanced TNM stage, lymphatic metastasis, distant metastasis, positive HER2 expression and ER expression in breast cancer patients.…”

Section: Discussionmentioning

confidence: 99%

FEZF1-AS1 functions as an oncogenic lncRNA in retinoblastoma

Quan

Wang

2019

Bioscience Reports

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Long non-coding RNA (lncRNA) FEZF1 antisense RNA 1 (FEZF1-AS1) has been shown to be up-regulated in tumor tissues and cells, and exerts oncogenic effects on various types of malignancies. However, the expression and function of FEZF1-AS1 was still fully unclear in retinoblastoma. The purpose of our study was to investigate the expression and clinical value of FEZF1-AS1 in retinoblastoma patients, and explore the effect of FEZF1-AS1 on retinoblastoma cell proliferation, migration and invasion. In our results, levels of FEZF1-AS1 expression were elevated in retinoblastoma tissue specimens and cell lines compared with adjacent normal retina tissue specimens and human retinal pigment epithelial cell line, respectively. The correlation analysis indicated that high FEZF1-AS1 expression was significantly correlated with present choroidal invasion and optic nerve invasion. Survival analysis suggested that retinoblastoma patients in high FEZF1-AS1 expression group had obviously short disease-free survival (DFS) compared with retinoblastoma patients in low FEZF1-AS1 expression group, and high FEZF1-AS1 expression was an independent unfavorable prognostic factor for DFS in retinoblastoma patients. Loss-of-function study indicated silencing FEZF1-AS1 expression inhibited retinoblastoma cell proliferation, invasion and migration. In conclusion, FEZF1-AS1 functions as an oncogenic lncRNA in retinoblastoma.

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Section: Discussionmentioning

confidence: 99%

FEZF1-AS1 functions as an oncogenic lncRNA in retinoblastoma

Quan

Wang

2019

Bioscience Reports

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“…Gong et al [45] applied qRT-PCR to detect 160 cases of NSCLC and its adjacent tissues, and found that compared with adjacent tissues, FEZF1-AS1 was significantly highly expressed in tumor tissues, and related to advanced TNM stages and tumor family history. In addition, they found that FEZF1-AS1 was highly correlated with FEZF1 in NSCLC [45].…”

Section: Fezf1-as1 In Various Human Malignanciesmentioning

confidence: 99%

FEZF1-AS1: a novel vital oncogenic lncRNA in multiple human malignancies

2019

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Long noncoding RNAs (LncRNAs) refer to the RNA with a length of >200 nucleotides, which lack or have no open reading coding frame and have higher tissue and organ specificity compared with the protein coding genes. A surging number of studies have shown that lncRNA is involved in numerous essential regulatory processes, such as X chromosome silencing, genomic imprinting, chromatin modification, transcriptional activation, transcriptional interference and nuclear transport, which are closely related to the occurrence and development of human malignancies. FEZ family Zinc Finger 1-Antisense RNA 1 (FEZF1-AS1) of FEZ family is a recently discovered lncRNA. FEZF1-AS1 is highly expressed in pancreatic cancer, colorectal cancer, lung adenocarcinoma and other human malignancies, and is associated with poor prognosis. As an oncogene, it plays crucial role in the proliferation, migration, invasion and Warburg effect of various tumor cells. In addition, FEZF1-AS1 is also involved in the regulation of multiple signal pathways such as epithelial–mesenchymal transition (EMT), signal transducer and activator of transcription 3 (STAT3) and Wnt/ β-catenin. In this paper, the recent research progress of FEZF1-AS1 in tumorigenesis and development is reviewed systematically.

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“…Downregulation of lncRNA RHPN1-AS1 induces gefitinib resistance through miR-299-3p/TNFSF12 in NSCLC [13]. LncRNA FEZF-AS1 [14] and lncRNA HOXA11-AS is associated with advanced clinical stages in NSCLC [15]. LncRNA DGCR5 mediates CSC-like properties through regulating miR-330-5p/CD44 in NSCLC [16].…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA LINC-PINT inhibits non-small cell lung cancer progression through sponging miR-218-5p/PDCD4

Zhang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Long noncoding RNA, long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT) was showed to be involved in cancer development. However, the biological effect of LINC-PINT on nonsmall cell lung cancer (NSCLC) remains unknown. Here, we aimed to investigate the role and underlying mechanism of LINC-PINT in NSCLC. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to measure the level of LINC-PINT in NSCLC tissues and cell lines. Cell counting kit-8 (CCK-8), flow cytometry, migration and transwell invasion assays were used to investigate cell proliferation, cell cycle, cell migration and invasion, respectively. The targets of LINC-PINT were verified by both luciferase reporter assay and RNA immunoprecipitation assay. Tumour xenografts were used to reveal the effect of LINC-PINT on tumourigenesis in vivo. We observed that LINC-PINT expression increased in both NSCLC tissues and cell lines. Function assays exhibited that LINC-PINT reduced NSCLC cell proliferation, cell cycle, cell migration and invasion in vitro. We also indicated that LINC-PINT mediated inhibitory effect on cell proliferation, cell cycle, cell migration and invasion by miR-208a-3p/programmed cell death 4 (PDCD4) in NSCLC cells. These findings indicated that LINC-PINT functions as a tumour-suppressor that exerts important regulatory roles in NSCLC progression by sponging miR-208a-3p/PDCD4.

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Upregulation of LncRNA FEZF-AS1 is associated with advanced clinical stages and family history of cancer in patients with NSCLC

Cited by 15 publications

References 26 publications

FEZF1-AS1 functions as an oncogenic lncRNA in retinoblastoma

FEZF1-AS1 functions as an oncogenic lncRNA in retinoblastoma

FEZF1-AS1: a novel vital oncogenic lncRNA in multiple human malignancies

Long noncoding RNA LINC-PINT inhibits non-small cell lung cancer progression through sponging miR-218-5p/PDCD4

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