Upregulation of p53 by tannic acid treatment suppresses the proliferation of human colorectal carcinoma

Karakurt, Serdar; Kandir, Sinan; Gökçek-Saraç, Çiğdem

doi:10.2478/acph-2021-0036

Cited by 3 publications

(1 citation statement)

References 62 publications

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“…After 48 h of treatment, the cell viability was determined via Alamar Blue Assay (Invitrogen, Thermo Fischer Scientific, Waltham, MA, USA) using a spectrophotometer (Thermo, MultiScanGO, USA), and the viable-dead cell ratios were determined using 0.04% "Trypan Blue" using an Automatic Cell Counting Device. 22…”

Section: Cell Culture and Treatmentmentioning

confidence: 99%

Investigation of structural differences of silica, silver and iron nanoparticles on the proliferation of human lung cancer

Karakurt¹,

Erturk²,

Sobaci³

et al. 2021

PPIJ

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Cancer is a complex disease that occurs with the uncontrolled division and proliferation of cells and is influenced by genetic and environmental conditions. 1 Today, breast cancer is the most common type of cancer in women and lung cancer in men. 2 The incidence of lung cancer, which is the most common respiratory system disease, is in the first place in men and third in women. Mortality in lung cancer comes first in both genders. 3 The most important reason for the high mortality is the difficulties encountered in early diagnosis. Despite the different drug effects, the therapeutic treatments or the combined therapeutic treatment formulation have had no impact on reducing tumorigenesis and mortality. 4,5 Commonly used treatment modalities are bone marrow transplant, radiotherapy, and chemotherapy. It has been observed that these traditional treatment methods in early diagnosis and treatment are sometimes insufficient both in diagnosis and treatment. With its insufficiency, it causes severe side effects and causes adverse effects on human life. The tendency to new treatment methods should be increased by using new technologies developed. Nanotechnology, which can be considered one of the best examples of developing technology, is a new science that carries out ambitious studies in health. Nanoparticles from nanostructures; consist of macromolecular materials and can be used therapeutically, especially in the controlled delivery of drugs to the desired area. 6 Nanoparticles are used as anticancer agents; It has been seen that they can be used for purposes such as reducing toxicity, improving in vivo and in vitro stability. In this way, while the intracellular concentrations and toxic effects of drugs in cancer cells can be increased, their harmful effects on healthy cells can be minimized. 7,8 Silver nanoparticles (AgNP), which have an important place among nanoparticles with proven biological activities, have been proven to have cytotoxic effects in prokaryotic cells and eukaryotic cells. 9 Because AgNPs containing hybrid molecular units have outstanding biocompatibility for therapeutic environments, they are used in the design of drug delivery systems sensitive to optical, thermal and pH modulations to target malignancies, inflammatory and infectious disorders. 10 AgNPs induce ROS accumulation in cancer cells, which leads to the inflammatory response, degradation, and subsequent destruction of mitochondria. 11 AgNPs have an effective toxic effect on many types of cancer. However, the different effects of the nanoparticles used, especially in various sizes, have different effects on the cells. 12 Silica nanoparticles are among the most popular nanoparticle types among researchers due to their superior properties with functional versatility. 13 Silica nanoparticles are one of the most preferred nanoparticles because they can be easily synthesized, functionalized in many different ways, biocompatible, stable in different conditions, and easy to apply. 14 Silica nanoparticles are highly effective in cancer treatment...

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Section: Cell Culture and Treatmentmentioning

confidence: 99%

Investigation of structural differences of silica, silver and iron nanoparticles on the proliferation of human lung cancer

Karakurt¹,

Erturk²,

Sobaci³

et al. 2021

PPIJ

Self Cite

View full text Add to dashboard Cite

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Investigation of In Vitro Antimicrobial and Cytotoxic Effects of Gold Nanoparticles Capped with Meropenem and Imipenem

Ciftci,

Sargin,

Arslan

et al. 2023

Nanomedicine (Lond.)

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Aim: This study aimed to investigate the in vitro antimicrobial effect of gold nanoparticles capped with meropenem and imipenem against various strains and to evaluate the cytotoxic effect of gold nanoparticles on healthy human colon epithelial cells. Materials & methods: Gold nanoparticles were synthesized via the Turkevich method and tested for antimicrobial effects using broth microdilution. Cell culture studies were performed using a cytotoxicity assay with alamarBlue™. Results & conclusion: Nanoparticles (10–20 nm) with antibiotic coating were more effective against Escherichia coli, Proteus spp. and Serratia marcescens than pure antibiotics. They had a cytotoxic effect on cells at high concentrations but were safe at low concentrations.

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Tannic acid elicits differential gene regulation in prostate cancer apoptosis

Kandir,

Karakurt,

Gökçek-Saraç

et al. 2024

Acta Pharmaceutica

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Prostate cancer is a significant global health concern that requires innovative therapeutic investigations. Here, the potential anticancer properties of tannic acid were evaluated by examining its effects on apoptosis in prostate cancer cell lines. PC-3 and LnCaP prostate adeno carcinoma cells, along with PNT1A prostate control cells, were cultured and divided into untreated and tannic acid-treated groups. Cell proliferation, cytotoxicity, and effects of tannic acid on the cell death mechanism were evaluated. mRNA expression levels of 84 genes were explored in cells following tannic acid treatment. Notably, tannic acid-induced down-regulation of several pro-survival genes, including ATM, BCL2, BCL2A1, BIK, BIRC2, BIRC3, BRE, CASP3, CASP6, CASP8, CHEK2, CRADD, PPIA, RPA3, TNFSF18, TRAF1, TRAF2, TRAF4, and TRAF5 in both cell lines. Moreover, tannic acid treatment led to the up-regulation of various pro-apoptotic genes, such as BCL10, BIRC3, BNIP3, CASP1, CASP5, CD40, CIDEB, DAPK2, FASLG, GADD45A, MYD88, RPA 3, TNFRSF10D, TNFRSF17, TNFRSF8, TNFSF13B, TNFSF4, TNFSF7, TNFSF8, TNFSF9, TP53, TRAF1, and TRAF2 in both PC-3 and LnCap cells. These findings highlight tannic acid’s ability to induce apoptosis in prostate cancer cells through pro-apoptotic pathways. This study concludes that tannic acid selectively inhibits prostate cancer cell growth.

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Upregulation of p53 by tannic acid treatment suppresses the proliferation of human colorectal carcinoma

Cited by 3 publications

References 62 publications

Investigation of structural differences of silica, silver and iron nanoparticles on the proliferation of human lung cancer

Investigation of structural differences of silica, silver and iron nanoparticles on the proliferation of human lung cancer

Investigation of In Vitro Antimicrobial and Cytotoxic Effects of Gold Nanoparticles Capped with Meropenem and Imipenem

Tannic acid elicits differential gene regulation in prostate cancer apoptosis

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