Urate Nephropathy

Foley, Richard J.; Weinman, Edward J.

doi:10.1097/00000441-198412000-00003

Cited by 10 publications

(1 citation statement)

References 20 publications

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“…In some adults, the occurrence of high SUA level might precede the development of CKD by many years [ 34 , 35 ]. Urate nephropathy was very frequent in patients with goat in the past [ 36 ]; however, the epidemiology of urate nephropathy in the era of XO inhibitors is poorly known [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Uric Acid Is a Weak Independent Predictor of Overall Survival in Older Adults

Winder

Owczarek

Mossakowska

et al. 2021

JCM

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Hyperuricemia accompanies many pathologies that contribute to overall death rate. The population-based multifaceted study of older adults in Poland made it possible to assess the effect of serum uric acid (SUA) on overall mortality. The PolSenior study performed between 2007–2011 included 3926 participants aged 65 years or above (mean age 79 ± 9 years) not treated with xanthin oxidase inhibitors (XOI) who were stratified by sex and SUA concentration into six subgroups increasing by 1 mg/dL. In 2019, survival data were retrieved from the population register. The crude risk of death was significantly higher in men and women with SUA ≥ 7 mg/dL. After adjustment to statistically significant factors, SUA remained a risk factor of death in men with SUA ≥ 8 mg/dL only, potentially due to the limited number of women with high SUA levels. Furthermore, age, heart failure, diabetes, and activities of daily living ≤ 4 pts were identified as factors increasing mortality risk regardless of sex. The risk of death increased also with smoking, past stroke, COPD/asthma, and hs-CRP > 3 mg/dL for men; and eGFR < 45 mL/min/1.73 m2, mini nutritional assessment ≤ 7 pts, and loop diuretics use for women. Mild hyperuricemia is a significant health status marker and an independent risk factor for overall mortality in older Caucasians not receiving XOI. Increased mortality is mostly limited to subjects with SUA levels ≥ 8 mg/dL.

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