“…For example, variations in pH control the protonation/deprotonation reactions (Tolls, 2001), temperature affects the degradation of antibiotics (Doi and Stoskopf, 2000), dissolved oxygen in groundwater can change aerobic biodegradation rates of EOCs (Al-Rajab et al, 2010;Barbieri et al, 2011), and thickness of the unsaturated zone is related to the potential degradation of EOCs (Sopilniak et al, 2018). On the other hand, major and trace elements such as NO3 and Se have been related to incidental or induced infiltration of sewage water (Dávila Pórcel et al, 2012), therefore qualifying as suitable markers of anthropogenic influence in the aquifer environment. Moreover, antibiotics may affect the natural microbial denitrification process (Ahmad et al, 2014;García-Galán et al, 2010).…”