Urgent problem of our time: the risk of developing radiation-induced stochastic diseases in the generations of children from irradiated parents

Балева, Л. С.; Сипягина, А. Е.

doi:10.21508/1027-4065-2019-64-1-7-14

Cited by 5 publications

(3 citation statements)

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“…Определение роли радиационного воздействия в риске неблагоприятных репродуктивных исходов является актуальным аспектом научного поиска во многих экспериментальных [2,3] и эпидемиологических исследованиях [4][5][6]. Согласно современным оценкам перинатальной смертности в когорте потомков жертв атомной бомбардировки в Японии [7], воздействие радиации на родителей было связано с повышенным риском серьезных врожденных пороков развития и перинатальной смерти, но оценки прямого воздействия радиации были неточными, и большинство из них не были статистически значимыми.…”

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“…Анализ мертворождений при внутриутробном внешнем гамма-облучении показал, что в дозовой категории 20,1-50 мГр риск у мальчиков основной группы почти в три раза превышал данные контрольной группы -2,8 (1, [3][4][5][6]2). Кроме того, статистически значимые различия наблюдались как в целом по группе: среди мальчиков -1,86 (1,2-2,9), оба пола -1,55 (1,16), так и в категории «нулевых» доз: среди мальчиков -2,14 (1, [2][3]85), оба пола -1,83 (1, 8).…”

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“…Signorello et al [28] в когортном анализе среди детей пациентов, перенесших рак в детстве, отмечают, что облучение матки и яичников значительно увеличивало риск мертворождения и неонатальной смерти при дозах более 10 Гр (9,1 [3,6]). Авторы указывают, что у девочек, получавших лечение до менархе, облучение матки и яичников в дозах 1,00-2,49 Гр значительно повышало риск мертворождения или неонатальной смерти (4,7 [1,[2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]0]). Практическая система радиационной защиты, рекомендованная Международной комиссией по радиационной защите (МКРЗ), подтверждает эмбриональную предрасположенность к летальным эффектам облучения в предимплантационный период эмбрионального развития, но отмечает, что при дозах ниже 100 мГр развитие таких летальных эффектов весьма редко [29].…”

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Risk of Perinatal Mortality Among the Offspring of Workers Employed at Production With Radiation Hazards

Sosnina,

Okatenko,

Sokolnikov

2023

Health risk analysis

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A retrospective analysis was performed among 25,007 children born in 1949–1973; parents of 14,580 of these children were exposed to long-term occupational radiation at Mayak PA. The study provides frequency and dynamics of perinatal mortality and comparative analysis of perinatal mortality by sex, year of birth, parental age at childbirth, and dose categories of radiation exposure. Research data were analyzed by methods of non-parametric statistics. We calculated a relative risk (RR) of perinatal mortality among the offspring of exposed and unexposed parents with 95 % CI. The rate of perinatal mortality was generally the same in both groups, 19.9 for 103 in the test group and 17.9 for 103 in the control, p > 0.05. Stillbirths among male offspring were statistically significantly more often observed in the test group due to contribution of the children with only mothers exposed to occupational radiation exposure at Mayak PA prior to conception and offspring exposed in utero. Intrauterine fetal death was observed statistically significantly more often among boys of the test group compared to controls: 2.9 against 0.9 for 103. Rates of stillbirths and perinatal mortality in the main group statistically significantly exceeded the values in the comparison group in 1949–1953: RR = 2.69 (CI: 1.46–4.95) and 2.12 (1.38–3.28) respectively. Significant statistical differences in the perinatal mortality risk were established in certain categories of preconception and intrauterine gamma-exposure. The identified peculiarities of unfavorable outcomes in the perinatal period that were detected among the offspring of Mayak PA workers could be eligible for further epidemiological monitoring. Poly-etiology character of perinatal mortality requires further follow up of the cohort of the offspring born to atomic production workers.

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Risk of Perinatal Mortality Among the Offspring of Workers Employed at Production With Radiation Hazards

Sosnina,

Okatenko,

Sokolnikov

2023

Health risk analysis

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The period of manifestation of type 1 diabetes mellitus in children and adolescents living on the territory of ZATO (Closed administrative-territorial entity)

Мargarita¹,

E²,

G³

2022

Glob J Obes Diabetes Metab Syndr

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Type 1 diabetes mellitus (T1DM) in children and adolescents remains one of the urgent problems of pediatric endocrinology. There is a constant increase in disease rates, both worldwide and Russia. The occurrence of pathology in childhood leads to a decrease in the quality of life of patients and their parents, the early development of chronic complications and disability, which makes type 1 diabetes a social problem in society. Despite numerous scientific works devoted to the study of the factors of manifestation of the disease, the causes of the occurrence are still unclear and ambiguous. The purpose of the study: is to identify and study possible clinical and laboratory features of the onset of type 1 diabetes in children and adolescents permanently residing in the territory of closed administrative-territorial entities (ZATO). Materials and methods: a continuous cohort retrospective study of children with type 1 DM was conducted for the period from 2009-2019, permanently residing in the ZATO territory to obtain data related to the period of manifestation of the disease. The study group included 55 children from 0 - 18 years of age suffering from type 1 diabetes. Results: Data on the anamnesis of life and disease, and indicators of clinical and laboratory studies (fasting glycemia, postprandial glycemia, average daily glycemia, average amplitude of glycemia fluctuations and glycated hemoglobin) at the time of disease manifestation are presented. A comparative analysis was carried out with the indicators of the Krasnoyarsk Territory, Russia, the obtained features were described.

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Search for polymorphic variants of candidate genes contributing to individual radiosensitivity

Исубакова¹,

Litviakov

Tsymbal³

et al. 2023

Bûll. sib. med.

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Background. Cytogenetic damage (СD) in lymphocytes induced by low doses (up to 0.1 Sv) of ionizing radiation (IR) is the main cytogenetic sign of individual radiosensitivity of the human body. In addition to DNA repair and cell death, which affect the formation of СD and its elimination, IR effects on the cell can be manifested through changes in proliferation of cells with unrepaired DNA damage. The system of cyclins and cyclin-dependent kinases (CDK), which provide coordination of mitotic events during passage of a cell through the cell cycle, plays a crucial role in regulation of cell proliferation.Aim. To evaluate the relationship of single-nucleotide polymorphisms (SNPs) of cell cycle genes with an increased frequency of СD in workers of a nuclear power plant affected by chronic occupational radiation exposure in the dose range of 100–500 mSv.Materials and methods. The object of the study was blood of 55 conditionally healthy workers of Siberian Chemical Plant (SCP) who were affected by chronic occupational radiation exposure (gamma radiation) in the dose range of 100–500 mSv. A standard cytogenetic analysis of blood lymphocytes was performed for all examined individuals. Genomic DNA was isolated from the blood of the workers using the QIAamp DNA Blood Mini Kit (QIAGEN, Germany). DNA was genotyped using 257 SNPs of cyclin genes and neighboring intergenic regions using DNA microarrays from the high-density CytoScan HD Array (Affymetrix, USA).Results. Taking into account the Bonferroni correction, only statistically significant associations of SNPs with the frequency of dicentric chromosomes were found; all other types of chromosomal aberrations did not show statistical significance. The rs803054 CCNI2 was associated with an increased frequency of dicentric chromosomes arising under the influence of chronic occupational radiation exposure.Conclusion. The discovered SNP (rs803054), whose recessive genotype is associated with an increased frequency of dicentric chromosomes in workers of SCP exposed to radiation at doses of 100–500 mSv over a long time, can be considered as a potential marker of individual radiosensitivity. To confirm the identified associations, further validation studies are needed on an expanded sample of people affected by chronic occupational radiation exposure.

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Urgent problem of our time: the risk of developing radiation-induced stochastic diseases in the generations of children from irradiated parents

Cited by 5 publications

References 10 publications

Risk of Perinatal Mortality Among the Offspring of Workers Employed at Production With Radiation Hazards

Risk of Perinatal Mortality Among the Offspring of Workers Employed at Production With Radiation Hazards

The period of manifestation of type 1 diabetes mellitus in children and adolescents living on the territory of ZATO (Closed administrative-territorial entity)

Search for polymorphic variants of candidate genes contributing to individual radiosensitivity

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