Uric acid as a future biomarker in diagnosing metabolic syndrome patients.

Abstract

Objectives: To determine the possible correlation between raised serum uric acid and various components of metabolic syndrome (Waist circumference, serum triglyceride, plasma HDL-C). Study Design: Descriptive case control. Setting: Army Medical College laboratory, Military Hospital, Rawalpindi. Period: One year (November 2014 to October 2015). Material and Methods: Total of 100 subjects were enrolled in this study. WHO criteria were applied for identifying the patients of metabolic syndrome. Fasting plasma glucose, lipid profile and serum uric acid levels were measured by using colorimetric enzymatic method. The formula of Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) was applied to calculate Insulin resistance. Collected data was analyzed by using SPSS- Window version-17 for statistical analysis. Results: Serum uric acid levels were turned out to be high in metabolic syndrome patients (cases= 6.1±1.3mg/dL) when compared with controls (having no symptoms of MetS=3.6±1.2; p<0.001). Uric acid showed a statistically significant positive association with waist circumference (WC=r-value:0.250; p-value:0.000) and serum triglyceride (TG=r-value:0.341; p-value:0.000). Negative correlation had been found between plasma high-density lipoprotein-cholesterol (HDL-C=r-value: -0.173; p-value:<0.01) with uric acid levels. Conclusion: Serum uric acid levels show a significant association with components of metabolic syndrome making it a powerful biomarker of metabolic syndrome and its various cardiometabolic complications.

Uric acid and metabolic syndrome: Findings from national health and nutrition examination survey

“…Our study findings suggest that hyperuricemia had significant statistical and clinical associations with MetS in participants in the NHANES study. These findings partially support previous studies that reported similar findings (15,25,26) but does not support previous studies that did not discover a relationship (11). Those participants with hyperuricemia (>7.0 mg/dL in males and >6.0 in females) in our study were more than three times as likely to have concomitant The individual correlation values (Pearson's r) are reported for the correlations between UA and the metabolic risk factor variables.…”

“…Additionally, hyperuricemia may increase insulin resistance, vasodilation, increase blood flow, interfere with nitric oxide function, and therefore affect glucose absorption. Previous studies (8,25,26) postulate that UA has an antioxidant effect at normal levels but becomes proinflammatory in people with hyperuricemia and increased oxidative stress. Our study findings support this previous research as hs-CRP was significantly and clinically lower in the normal UA group.…”