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Objectives: To determine the possible correlation between raised serum uric acid and various components of metabolic syndrome (Waist circumference, serum triglyceride, plasma HDL-C). Study Design: Descriptive case control. Setting: Army Medical College laboratory, Military Hospital, Rawalpindi. Period: One year (November 2014 to October 2015). Material and Methods: Total of 100 subjects were enrolled in this study. WHO criteria were applied for identifying the patients of metabolic syndrome. Fasting plasma glucose, lipid profile and serum uric acid levels were measured by using colorimetric enzymatic method. The formula of Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) was applied to calculate Insulin resistance. Collected data was analyzed by using SPSS- Window version-17 for statistical analysis. Results: Serum uric acid levels were turned out to be high in metabolic syndrome patients (cases= 6.1±1.3mg/dL) when compared with controls (having no symptoms of MetS=3.6±1.2; p<0.001). Uric acid showed a statistically significant positive association with waist circumference (WC=r-value:0.250; p-value:0.000) and serum triglyceride (TG=r-value:0.341; p-value:0.000). Negative correlation had been found between plasma high-density lipoprotein-cholesterol (HDL-C=r-value: -0.173; p-value:<0.01) with uric acid levels. Conclusion: Serum uric acid levels show a significant association with components of metabolic syndrome making it a powerful biomarker of metabolic syndrome and its various cardiometabolic complications.

Objectives: To evaluate and compare blood glucose levels and lipid profile in diabetic vs healthy adults. Methodology: This descriptive cross sectional study was conducted from January 2021 to April 2021. The study samples were collected from Northwest General Hospital Peshawar. Sixty patients with diagnosed type 2 diabetes and an equal number of control subjects were included in this study. After the recruitment of subjects according to the inclusion criteria, subjects were divided into two cohorts; Patients with Diabetes (Group I N=60) and a Non-Diabetic Control Group (Control group N=60). Blood from the subjects was checked for glucose levels and lipid profile. Blood was taken and analysed at the Hospital Lab via Cobas 6000 analyser. Data was analysed using SPSS version 26.0 for MacBook Pro. T test was applied to the data and p value was kept at 0.05 for significance. Results: Fasting Blood Glucose (FBS) rise was statistically significant (p=0.03) with a mean and standard deviation (SD) of 161.21±46.31* for Group I and 79.29±18.56 for Group II with a Mean Difference (MD) of 81.92.

Aim: To determine the frequency of hypocalcemia with exchange transfusion in neonatal jaundice. Study design: Descriptive cross-sectional study Place and duration of study: Departments of Pediatrics and Pathology, Naseer Teaching Hospital Peshawar from 1stJanuary 2018 to 31st December 2018. Methodology: One hundred and sixty twopatients of jaundiced neonates having total serum bilirubin >20mg/dl, both gender and patients having age up to 14 days were included. Patients fulfilling the selection criteria had undergone exchange transfusion. Hypocalcaemia was evaluated and considered positive if calcium serum level is <8 mg/dl or <2 mmol/L. Results: 50% of neonates were between 1-5 days, 45% of neonates were between 5-10 days, and 3% of neonates were in age 10-14 days. One hundred and ten (68%) of neonates were males and 52 (32%) of neonates were females. 30% neonates had hypocalcemia while 70% were without hypocalcemia. Conclusion: The incidence of hypocalcemia was found to be 30% with exchange transfusion in neonatal jaundice. Keywords: Hypocalcemia, Exchange transfusion, Neonatal jaundice

Aim: Evaluate the histological findings of celiac disease and to analyze the variations that occurred in biopsies. We aimed to execute the GFD method which helps us in diagnosing and managing celiac disease during follow-up. Methodology: This retrospective study was conducted at the Rawalpindi Medical University hospital from September 2020 to September 2021. Standard bioptic forceps and flexible endoscopes were used to perform upper GIT endoscopy and biopsies. For every patient, we collected 4 biopsy specimens from the duodenum. We cut 3μm thick sections from each block and stained them in a hematoxylin compound. We counted intraepithelial lymphocytes using anti-CD3 immuno histochemical staining. Results: We recruited 69 celiac patients with a total of 2,760 power fields. Out of these 69 patients, 52 were (76%) females and 17 (24%) were males. Patients from the age range 14 to 69 were recruited. The mean age of patients was reported as 39 ± 15 years. By the EF method, we observed improvement in histological patterns of 8 patients, and one remain unchanged. Only 2 cases reported worsened histological outcomes. Conclusion: Interpretation of duodenal biopsies demands different methods of analysis based on the clinical settings to address the presence of atrophy and improvements in CD patients. Keywords: Celiac disease, Marsh-Oberhuber scale, endoscopy