Uric acid homeostasis in lean and obese girls during pubertal development

Garbagnati, Ersilia; Boschetti, Marzia

doi:10.1016/0026-0495(94)90260-7

Cited by 20 publications

(11 citation statements)

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“…It is of relevance to the present findings that fractional excretion rate of uric acid is diminished in hypertriglyceridaemic individuals [31] and that dietary changes which lower TG seem to be able to reverse this process [32]. Garbagnati and Boschetti found that the increase of serum uric acid during female puberty was related to decreased renal clearance in lean girls (BMI 16) but not in those who were obese (BMI 26), suggesting enhanced uric acid production in the latter group [33]. Leyva et al proposed a disturbance in the glycolytic pathway as a key factor behind increased uric acid synthesis [9], but their suggestion that it is related to insulin resistance is not supported by our data.…”

Section: Discussionsupporting

confidence: 62%

Serum uric acid in traditional Pacific Islanders and in Swedes

Lindeberg

Cordain

Råstam

et al. 2004

Journal of Internal Medicine

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Section: Discussionsupporting

confidence: 62%

Serum uric acid in traditional Pacific Islanders and in Swedes

Lindeberg

Cordain

Råstam

et al. 2004

Journal of Internal Medicine

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“…This gain in mean serum uric acid concentration during adolescence can be found in populations of normal-weight and normouricemic adolescents as well as in samples of overweight adolescents with significantly elevated serum levels of uric acid [6][7] . Between the age of 15 and 17 years adult normal values are reached 3 " 5 .…”

Section: Introductionmentioning

confidence: 77%

Serum Uric Acid Levels in Obese Children and Adolescents: Linkage to Testosterone Levels and Pre-metabolic Syndrome

Denzer¹,

Muche²,

Mayer³

et al. 2003

Journal of Pediatric Endocrinology and Metabolism

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Hyperuricemia is part of the "metabolic syndrome". The aim of this study was to investigate the regulation and role of serum uric acid in the cardiovascular risk factor profile of obese children and adolescents. Serum levels of uric acid and selected risk factors and hormones were determined in 269 children aged 10.0-15.9 years with a BMI >90th percentile (mean 24.0 kg/m2, SD 5.43). Stepwise regression adjusted for age and sex revealed that testosterone (p < 0.0001), BMI (p < 0.0001), systolic blood pressure (p < 0.0017), triglycerides (p < 0.0345) and cholesterol/HDL ratio (p < 0.0393) were positively correlated with serum uric acid and accounted for 42.1% of the variance. Additional regression models with the same set of variables indicated that uric acid contributed significantly to levels of cholesterol/HDL, total cholesterol, BMI and systolic blood pressure, respectively. These results suggest a not yet described impact of androgens in the regulation of serum uric acid in obese children and adolescents. Furthermore, they show that uric acid is a reliable indicator for the "pre-metabolic syndrome" in obese youths.

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“…Recent studies on uric acid homeostasis during pubertal development have shed more light on the role of obesity. The results of these studies suggest that serum uric acid levels are especially due to decreased renal uric acid excretion in lean subjects, whereas in obese subjects uric acid overproduction also seems to be involved [49,50]. In contrast, it has been suggested that plasma lipoproteins affect serum uric acid levels especially by its renal excretion [51].…”

Section: Figurementioning

confidence: 97%