Urinary concentrations of 2,5-dichlorophenol and diabetes in US adults

Wei, Yudan; Zhu, Jianmin

doi:10.1038/jes.2015.19

Cited by 15 publications

(9 citation statements)

References 29 publications

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“…Epidemiological studies suggest that exposure to dichlorophenol increases morbidity due to asthma, total serum levels of immunoglobulin E (IgE) in patients with atopy and a history of wheezing, and contributes to the increasing incidence of food allergies [ 8 , 9 ]. Furthermore, exposure to 2,5-DCP causes metabolic syndrome, diabetes, and obesity, while concentrations of 2,4-DCP in urine are reportedly significantly associated with olfactory dysfunction [ 10 , 11 , 12 , 13 , 14 ]. Following exposure, 2,4-DCP and 2,5-DCP are readily absorbed from the gastrointestinal tract and metabolized to glucuronide and other conjugates.…”

Section: Introductionmentioning

confidence: 99%

Concentrations of 2,4-Dichlorophenol and 2,5-Dichlorophenol in Urine of Korean Adults

Park

Kim

2018

IJERPH

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Humans are exposed to the environmental pollutants 2,4-dichlorophenol (2,4-DCP) and 2,5-dichlorophenol (2,5-DCP) through air, the use of water and the consumption of products. In this study, we evaluated the urinary concentrations of these compounds in Korean people between the ages of 18 to 69 years, by making use of data from the Korean National Human Biomonitoring Survey that was completed in 2009. Of 1865 representative Koreans, 63.4% and 97.9% were found to have concentrations of 2,4-DCP and 2,5-DCP > 0.05 μg/L (limit of detection) in their urine, respectively. The geometric mean of urinary concentrations was 0.14 μg/L (confidence interval of 95% = 0.13–0.16) and 0.44 μg/L (confidence interval = 0.41–0.48), respectively. It was found that the adjusted proportional changes in 2,4-DCP concentrations were significantly associated with body mass index, whereas those of 2,5-DCP concentrations were influenced by place of residence. From these findings, it is evident that most adults in Korea have levels of 2,4-DCP and 2,5-DCP that are detectable in their urine and the burden of these compounds on their bodies varies depending on numerous demographic factors.

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Section: Introductionmentioning

confidence: 99%

Concentrations of 2,4-Dichlorophenol and 2,5-Dichlorophenol in Urine of Korean Adults

Park

Kim

2018

IJERPH

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“…In the prior NHANES analysis of DCP and diabetes, there was a dose-dependent association between urinary 2,5-DCP quartiles and higher diabetes prevalence; 2,4-DCP was not related to diabetes prevalence 11. Higher 2,5-DCP concentrations were also associated with a greater prevalence of metabolic syndrome in non-diabetic adults; 2,4-DCP was not associated with prevalence of metabolic syndrome 12.…”

Section: Discussionmentioning

confidence: 88%

“…Prior NHANES studies have examined urinary 2,5-DCP in relation with allergies,9 asthma,10 diabetes,11 obesity,13 14 metabolic syndrome12 and thyroid function,15 16 while 2,4-DCP has been examined in relation to allergies,9 asthma,10 diabetes,11 obesity13 14 and olfactory dysfunction 18. In the prior NHANES analysis of DCP and diabetes, there was a dose-dependent association between urinary 2,5-DCP quartiles and higher diabetes prevalence; 2,4-DCP was not related to diabetes prevalence 11.…”

Section: Discussionmentioning

confidence: 99%

“…Prior NHANES analyses have reported associations of higher concentrations of 2,5-DCP with greater prevalence of asthma (among atopic wheezers),9 allergies10 and metabolic abnormalities such as diabetes,11 metabolic syndrome,12 obesity,13 14 adverse concentrations of thyroid function biomarkers among both adult15 and adolescent16 participants and with younger age of menarche among adolescent girls 17. 2,4-DCP has been included in only some of these NHANES analyses.…”

Section: Introductionmentioning

confidence: 99%

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Urinary 2,5-dicholorophenol and 2,4-dichlorophenol concentrations and prevalent disease among adults in the National Health and Nutrition Examination Survey (NHANES)

et al. 2018

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ObjectiveTo test cross-sectional associations between urinary concentrations of 2,5-dichlorophenol (2,5-DCP) and 2,4-dichlorophenol (2,4-DCP) with the prevalence of cardiovascular disease (CVD), cancer, lung disease, thyroid problems and liver conditions.MethodsLogistic regression was used to evaluate associations of urinary concentrations of 2,5-DCP and 2,4-DCP with prevalence of various medical conditions among 3617 National Health and Nutrition Examination Survey participants from 2007–2008 and 2009–2010. ORs and 95% CIs for each disease were estimated. All regression models were adjusted for urinary creatinine.ResultsWe observed a monotonically increasing association between quartiles of 2,5-DCP and prevalence of CVD. After adjustment for sociodemographic and lifestyle characteristics, participants with the highest versus lowest quartile of urinary 2,5-DCP had an OR=1.84 (95% CI 1.26 to 2.70) (p linear trend=0.006). The association was similar with further adjustment for established clinical CVD risk factors. Higher 2,5-DCP was also associated with prevalence of all cancers combined (ORQ4 vs Q1=1.50 (95% CI 1.00 to 2.26); p trend=0.05) and, in exploratory analyses, with gynaecological cancers (ORQ4 vs Q1=4.15 (95% CI 1.51 to 11.40; p trend=0.01)). No associations were detected between 2,5-DCP and lung diseases, thyroid problems or liver conditions, nor between 2,4-DCP and prevalent disease.ConclusionIn this nationally representative study, higher urinary 2,5-DCP concentrations were associated with greater prevalence of CVD and all cancers combined. Further examination may be warranted to assess whether chronic exposure to 2,5-DCP is associated with incidence of adverse health outcomes.

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“…p-DCB, an organic compound, is poorly soluble in water and has been widely used as a disinfectant, pesticide, and deodorant [9,10]. Similar to some hydrocarbons, p-DCB exists in new buildings, restrooms, and the air of households [11]. The International Agency for Research on Cancer (IARC) suggested that p-DCB may reasonably be a carcinogen base on animal evidence [10].…”

Section: Introductionmentioning

confidence: 99%

Associations of dichlorophenol with metabolic syndrome based on multivariate-adjusted logistic regression: A U.S. nationwide population-based study 2003-2016

Cai

Yang

Xing

2023

Preprint

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Background Para-dichlorobenzene (p-DCB) exposure associated with oxidative stress has indeed raised public concerns. However, whether p-DCB is linked with metabolic syndrome (MetS) remains unclear. This study aimed to examine the associations of exposure to p-DCB with MetS prevalence. Methods We included 10,428 participants (5,084 men and 5,344 women) adults (aged ≥ 20 years) from the National Health and Nutrition Examination Survey (2003–2016). The cases of MetS were diagnosed by NCEP/ATPIII. Logistic regression models were conducted to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) of MetS prevalence. Results We documented 2,861 (27.1%) MetS cases. After adjustment for the potential risk factors, the ORs (95% CI) of MetS prevalence across the quartile of urinary 2,5-dichlorophenol (2,5-DCP) were 1.09 (0.93–1.28), 1.22 (1.00-1.49), and 1.34 (1.04–1.73). Moreover, 2,5 DCP is significantly associated with a higher prevalence of abdominal obesity. We further examined that 2,5 DCP was correlated with higher systolic blood pressure, waist circumference, and glycohemoglobin and a lower high density cholesterol. In addition, the significant positive associations between 2,5 DCP and MetS were robust in the subgroup and sensitivity analyses. Conclusion These findings indicated that increased urinary p-DCB concentration, especially 2,5 DCP, had a higher MetS prevalence.

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Urinary concentrations of 2,5-dichlorophenol and diabetes in US adults

Cited by 15 publications

References 29 publications

Concentrations of 2,4-Dichlorophenol and 2,5-Dichlorophenol in Urine of Korean Adults

Concentrations of 2,4-Dichlorophenol and 2,5-Dichlorophenol in Urine of Korean Adults

Urinary 2,5-dicholorophenol and 2,4-dichlorophenol concentrations and prevalent disease among adults in the National Health and Nutrition Examination Survey (NHANES)

Associations of dichlorophenol with metabolic syndrome based on multivariate-adjusted logistic regression: A U.S. nationwide population-based study 2003-2016

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