Urinary Excretion Profile of Torasemide and its Diuretic Action in Dogs

Sogame, Yoshihisa; Okano, Kanemichi; Hayashi, Kazutaka; Uchida, Takeshi; Tsuda, Yoshio

doi:10.1111/j.2042-7158.1996.tb05936.x

Cited by 14 publications

(22 citation statements)

References 9 publications

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“…In contrast, the urinary excretion rate of torasemide is much lower, and decreases gradually [12]. The plasma concentration of torasemide also decreases more slowly.…”

Section: Discussionmentioning

confidence: 79%

“…The plasma concentration of torasemide also decreases more slowly. The slower transfer rate from plasma to the nephron leads to the longer-lasting diuretic action of torasemide compared with furosemide [12]. In both cats and dogs, a diuretic effect was observed 12 hr after the administration of torasemide, whereas the effect of furosemide diminished at 5~6 hr.…”

Section: Discussionmentioning

confidence: 86%

“…The urinary excretion rate of furosemide is very high after intravenous administration and decreases rapidly in dogs [12]. In contrast, the urinary excretion rate of torasemide is much lower, and decreases gradually [12].…”

Section: Discussionmentioning

confidence: 91%

“…Con trol and mitral regurgitation dogs were given oral placebo, torasemide 0.2 mg/kg, and furosemide 2 mg/kg for 7 days. Urine samples were obtained at baseline and 1, 2,3,4,5,6,8,12, and 24 hr after each drug dose. Urine volume and urine Na + and K + were measured.…”

mentioning

confidence: 99%

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The Effects of the Loop Diuretics Furosemide and Torasemide on Diuresis in Dogs and Cats

Uechi

Matsuoka

Kuwajima

et al. 2003

The Journal of Veterinary Medical Science

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ABSTRACT. Torasemide is a new loop diuretic that combines the effects of furosemide and spironolactone. There are no reports on the effects of torasemide in cats and dogs. This study compared the diuretic effects of furosemide and torasemide in cats and dogs. Cats with pressure overload cardiac hypertrophy were given oral placebo, torasemide 0.3 mg/kg, or furosemide 1 mg/kg or 3 mg/kg. Con trol and mitral regurgitation dogs were given oral placebo, torasemide 0.2 mg/kg, and furosemide 2 mg/kg for 7 days. Urine samples were obtained at baseline and 1, 2,3,4,5,6,8,12, and 24 hr after each drug dose. Urine volume and urine Na + and K + were measured. Both furosemide and torasemide increased urine volume 1 hr after administration. Furosemide caused a dose-dependent increase in urine volume that peaked at 2-3 hr in cats and dogs. The diuretic effect of furosemide disappeared 6 hr after administration, while that of torasemide peaked 2-4 hr after administration and persisted for 12 hr in cats and dogs. In MR dogs, torasemide for 7 days signi ficantly decreased urine potassium excretion. Plasma aldosterone increased with torasemide, whereas there was no change with furosemide. In conclusion, about 1/10 concentration of torasemide was as potent as furosemide and had a longer diuretic effect in cats and dogs . These data suggest that torasemide is useful for treating congestive heart failure or edema in cats and dogs. KEY WORDS: diuretic agent, feline, heart failure, renal function, urine.J. Vet. Med. Sci. 65(10): 1057-1061, 2003 Torasemide is a pyridyl sulfonylurea with a chemical structure between those of loop diuretics and Cl-channel blockers [5,13,20]. The main tubular site of action of torasemide is the ascending limb of the loop of Henle, where it interacts with the Na + , 2Cl -, K + cotransporter localized in the luminal surface [19,20]. Torasemide and furosemide cause a significant, dose-dependant increase in urine flow and the urinary excretion of sodium and potassium [14]. Torasemide has more potent, longer-acting diuretic activity than furosemide [3]. Congestive heart failure, which is characteristically associated with fluid retention and shortness of breath, is a leading cause of morbidity and mortality. Therefore, animals with congestive heart failure require management with diuretics, such as thiazide, bumetanide, and furosemide. Furosemide is the diuretic most frequently given for edema. Although torasemide has beneficial effects in chronic congestive heart failure in humans [8], there are fewer clinical reports than on furosemide. In veterinary medicine, there are no reports on the dose or diuretic effects of torasemide for dogs and cats. Therefore, this study compared the diuretic effects of torasemide and furosemide in dogs and cats. MATERIALS AND METHODSThis study followed the Guidelines for Institutional Laboratory Animal Care and Use of the School of Veterinary Medicine and Animal Science at Kitasato University.Cat study: This study used 8 clinically healthy domestic short hair cats (4 males, 4 fem...

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“…In contrast, the urinary excretion rate of torasemide is much lower, and decreases gradually [12]. The plasma concentration of torasemide also decreases more slowly.…”

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 91%

mentioning

confidence: 99%

See 2 more Smart Citations

The Effects of the Loop Diuretics Furosemide and Torasemide on Diuresis in Dogs and Cats

Uechi

Matsuoka

Kuwajima

et al. 2003

The Journal of Veterinary Medical Science

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“…4,5 Its primary site of action is the thick ascending loop of Henle in the nephron, where it promotes excretion of sodium, water, and chloride via interaction with the Na þ , K þ , 2Cl À cotransporter. 4,6,7 In humans, torsemide has a higher bioavailability, longer halflife, and longer duration of action than furosemide, resulting in a more uniform action of diuresis that is both stronger and more effective.…”

Section: Introductionmentioning

confidence: 99%

Effect of torsemide and furosemide on clinical, laboratory, radiographic and quality of life variables in dogs with heart failure secondary to mitral valve disease

Peddle¹,

Singletary²,

Reynolds³

et al. 2012

Journal of Veterinary Cardiology

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Evaluation of the short‐term echocardiographic effects of two loop diuretics, furosemide and torsemide, in a group of dogs

Hosseini,

Mahmoudi Filabadi,

Hill

et al. 2023

Veterinary Medicine & Sci

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Background: Two loop diuretics, torsemide and frusemide, can affect the urinary system and consequently the cardiordiovascular haemodynamics in different ways.Objectives: This study compared a number of echocardiographic parameters and systemic arterial blood pressure (ABP) changes following administration of furosemide or torsemide.Methods: Five shelter dogs underwent transthoracic two-dimensional M-mode echocardiography to obtain the following measurements: left ventricular internal dimension at end-systole (LVIDs), left ventricular internal dimension at end-diastole (LVIDd), fractional shortening (FS), heart rate (HR) and the distance between the mitral valve socket and the ventricle wall (septal to E Point, SEP). Arterial blood pressure was measured using the oscillometric method. Measurements recorded before treatment (baseline data) were compared to those after the dogs received furosemide (5 mg/kg) or torsemide (0.5 mg/kg).Results: Torsemide significantly reduced blood pressure 1 h after administration, but this was not seen with furosemide. Fractional shortening, LVIDd and SEP decreased following both treatments, but there were no significant differences between the treatment groups. Torsemide increased heart rate above that seen in the furosemide groups. Conclusions:The results of this study indicate that 1 h after administration, torsemide increases heart rate and decreases blood pressure when compared to furosemide, but both drugs have similar effects on measured cardiovascular indices.

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Urinary Excretion Profile of Torasemide and its Diuretic Action in Dogs

Cited by 14 publications

References 9 publications

The Effects of the Loop Diuretics Furosemide and Torasemide on Diuresis in Dogs and Cats

The Effects of the Loop Diuretics Furosemide and Torasemide on Diuresis in Dogs and Cats

Effect of torsemide and furosemide on clinical, laboratory, radiographic and quality of life variables in dogs with heart failure secondary to mitral valve disease

Evaluation of the short‐term echocardiographic effects of two loop diuretics, furosemide and torsemide, in a group of dogs

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