Urinary Iodine Levels and Thyroid Diseases in Children; Comparison between Nagasaki and Chernobyl.

Ishigaki, Katsu; Namba, Hiroyuki; Takamura, Noboru; Saiwai, Hirokazu; Parshin, V. S.; Ohashi, T.; Kanematsu, Takashi; Yamashita, Shunichi

doi:10.1507/endocrj.48.591

Cited by 23 publications

(22 citation statements)

References 11 publications

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“…Zava and Zava 7 estimated that Japanese iodine intake, which comes largely from seaweed consumption, ranges from 1 to 3 mg/day. The mean or median UIC of Japanese residents ranges from 281 to 3300 μg/L in many regions of Japan 8, 9, 10, 11, 12, 13, 14.…”

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confidence: 99%

Genetic alterations of differentiated thyroid carcinoma in iodine‐rich and iodine‐deficient countries

et al. 2016

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BRAF V600E mutation, RET rearrangements, and RAS mutations are the common genetic alterations in differentiated thyroid carcinomas derived from follicular thyroid cells. However, the relationship between these alterations and iodine intake is still controversial. To clarify the influence of iodine intake on the occurrence of differentiated thyroid carcinomas, we performed molecular analyses for two differentiated carcinomas, papillary thyroid carcinomas (PTCs) and follicular thyroid carcinomas (FTCs), from an iodine‐rich country (Japan) and an iodine‐deficient country (Vietnam). We examined 120 PTCs (67 Japanese and 53 Vietnamese) and 74 FTCs (51 Japanese and 23 Vietnamese). We carried out allele‐specific polymerase chain reaction (AS‐PCR) for BRAF V600E, PCR and direct sequencing for RAS mutations (codon 12, 13, and 61 in NRAS,HRAS, and KRAS), and RT‐PCR for RET/PTC1 and RET/PTC3. BRAF V600E was present in 55/67 (82.1%) Japanese PTCs and 44/53 (83%) Vietnamese PTCs. RET/PTC1 was identified in only one PTC from each country, and no samples had RET/PTC3. NRAS mutation was found in 17/51 (33.3%) Japanese FTCs and 4/23 (17.4%) Vietnamese FTCs. NRAS mutation was cited in codon 61 (20 cases) and codon 12 (one case). None of FTCs had KRAS or HRAS mutations. There were no significant differences in the prevalence of BRAF V600E,RET/PTC, or RAS mutations between the two countries. Our study showed no differences in genetic alterations of thyroid cancers from iodine‐rich and iodine‐deficient countries, possibly suggesting that iodine intake might not affect the genetic alterations of differentiated thyroid cancer.

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Genetic alterations of differentiated thyroid carcinoma in iodine‐rich and iodine‐deficient countries

et al. 2016

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“…Iodine environment could be one of the possible factors that contribute to these differences [6]. The area around Chernobyl is wellknown as an iodine-deficient area in stark contrast to Japan, an iodine-rich country [6][7][8][9][10][11]. Urinary content of Ukrainians is about one-tenth (10%) of that of Japanese.…”

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Morphological difference in adult thyroid papillary carcinoma between Japan and Ukraine

et al. 2014

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“…According to our recent study, the median level of urinary iodine in Japan was 362.6 mg/L among schoolchildren and 612.0 mg/L among adults [5]. In this country, a guideline for iodine prophylaxis has not been established, since the necessity of such action in iodine-rich areas is controversial.…”

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Urinary Iodine Kinetics after Oral Loading of Potassium Iodine

et al. 2003

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Abstract. We studied the kinetics of iodine in various forms, in order to establish appropriate guidelines of iodine prophylaxis for thyroid blockade at nuclear emergency in "iodine rich areas", such as Japan. First, the effect of equivalent dose of potassium iodide (KI) (solution vs. tablet) was evaluated with excretions of urinary iodine (UI) at Nagasaki, Japan, and it was revealed that there was no difference of iodine kinetics between solution and tablet. We also performed the same study at Gomel, Belarus, which was known to be an iodine deficient area, and obtained the same results. Second, the kinetics of iodine included in "iodine rich" food was also evaluated with excretions of UI. Interestingly, the ratio of UI excretion with iodine rich food was significantly lower than that with KI tablets until 6 h after the intake (ANOVA, p = 0.02). These results proved that 1) KI solution as well as its tablet is useful for prophylaxis and 2) prophylaxis by iodine rich food is not effective for rapid blockade of thyroid gland at nuclear emergency. Finally, we emphasized that the approach from social medicine is definitely important to establish an effective iodine prophylaxis.

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Urinary Iodine Levels and Thyroid Diseases in Children; Comparison between Nagasaki and Chernobyl.

Cited by 23 publications

References 11 publications

Genetic alterations of differentiated thyroid carcinoma in iodine‐rich and iodine‐deficient countries

Genetic alterations of differentiated thyroid carcinoma in iodine‐rich and iodine‐deficient countries

Morphological difference in adult thyroid papillary carcinoma between Japan and Ukraine

Urinary Iodine Kinetics after Oral Loading of Potassium Iodine

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