Urinary polyamine levels in patients with localized malignancy

Lipton, Allan; Sheehan, Linda; Mortel, Rodrique; Harvey, Harold A.

doi:10.1002/1097-0142(197609)38:3<1344::aid-cncr2820380338>3.0.co;2-y

Cited by 22 publications

(6 citation statements)

References 4 publications

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“…when she reported that patients with cancer excreted increased amounts of polyaniines in The potential clinical application of polyamines was suggested by Russell (197 1) urine. Since then, several investigators have reported elevated urinary polyamine levels among many patients with various solid tumors (Savory and Shipe, 1975;Bachrach, 1976), including patients with both localized and advanced disease (Lipton et al, 1975;Waalkes et al, 1975;Lipton et al, 1976).…”

Section: Introductionmentioning

confidence: 99%

Serum polyamine alterations in surgical patients with colorectal carcinoma

Nishioka

Romsdahl

McMurtrey

1977

Journal of Surgical Oncology

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Polyamines, by virture of their regulatory role in the cellular synthesis of DNA, RNA, and protein, are potential indicators of malignant growth. In view of this, serum polyamine levels of patients with colorectal carcinoma or benign bowel disease were examined. Of 53 patients with colorectal carcinoma, 35 (66%) showed elevations of 1 or more polyamines. Nine patients with benign bowel disease (villous adenoma, Gardner's syndrome, familial polyposis, and diverticulitis) showed normal serum polyamine levels except 1 patient with a villous adenoma. Patients with colorectal carcinoma were designated stage A, B, C, or D depending on the progression of their disease. All patients classified as D showed elevation of 1 or more polyamines. Serum polyamines became elevated following surgery in patients with colorectal carcinoma as well as those with benign bowel diseases, suggesting a relationship to the surgical procedure. Preliminary longitudinal studies of patients with colorectal carcinoma (B stage) undergoing curable surgical procedures show normal polyamine levels and no evidence of disease at 15 months.

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Section: Introductionmentioning

confidence: 99%

Serum polyamine alterations in surgical patients with colorectal carcinoma

Nishioka

Romsdahl

McMurtrey

1977

Journal of Surgical Oncology

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“…12 patients with head and neck cancer before and after either surgical or radiation therapy. the tumors were relatively small, the values in some were not above the normal range.…”

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confidence: 99%

Erythrocyte Polyamine Determinations in Patients With Head and Neck Cancer

Shideler¹,

Johns²,

Cantrell³

et al. 1981

Archives of Otolaryngology - Head and Neck Surgery

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\s=b\ Erythrocyte polyamine levels were measured in the blood from 29 untreated patients whose conditions were diagnosed as head and neck cancer. Only nine (31%) of these patients had elevations of erythrocyte spermidine and/or spermine levels above the reference ranges determined for normal persons.However, a positive correlation was observed between the erythrocyte spermidine levels and the clinical tumor stage. Serial erythrocyte polyamine determinations were performed on the blood from 12 of these patients before and after either surgical or radiation therapy. In 11 of the cases, the erythrocyte spermidine levels decreased after tumor therapy regardless of whether there was prior elevation above the reference range. The erythrocyte spermine levels in these patients were more variable in their response to tumor treatment. Therefore, although erythrocyte polyamine levels were only slightly to moderately elevated in response to the small tumors characteristic of the head and neck, the measurement of erythrocyte spermidine, potentially, may offer a simple and effective means of monitoring the course of therapy used in patients with head and neck cancer. (Arch Otolaryngol 1981;107:752-754) The naturally occurring aliphatic polyamines, putrescine, spermi¬ dine, and spermine, are found in all types of cells.12 Although their exact physiologic function is unknown, it has been shown that they play neces¬ sary roles in cell growth and that their rate of accumulation parallels the rate of cellular proliferation.3 4 The struc¬ tures of these compounds are as fol¬ lows:Evidence has accumulated during the past ten years that suggests that polyamines are of potential value as

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“…Independent studies involving large numbers of patients showed that the levels of these amines were elevated in the urine of a majority of the cancer patients (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). One comprehensive study indicated that the potential usefulness of the urinary polyamines as biological markers was less promising than originally anticipated (13).…”

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confidence: 99%

“…In most previous studies, the biological samples (urine, serum, and cerebrospinal fluid) were hydrolyzed prior to analysis. The data presented (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) pertain to the quantities of total polyamines excreted in urine and not to the nature of these amines.…”

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confidence: 99%

“…Since the initial report (1) describing elevated levels of polyamines in urine of cancer patients, interest in the possible use of urinary polyamine levels as biochemical markers of tumor presence and growth has increased. Independent studies involving large numbers of patients showed that the levels of these amines were elevated in the urine of a majority of the cancer patients (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). One comprehensive study indicated that the potential usefulness of the urinary polyamines as biological markers was less promising than originally anticipated (13).…”

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confidence: 99%

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