Urinary Tract Infections Following Renal Transplantation: A Single-Center Experience

Memikoğlu, Kemal Osman; Keven, Kenan; Şengül, Şule; Soypaçacı, Zeki; Ertürk, Şehsuvar; Erbay, Bülent

doi:10.1016/j.transproceed.2007.10.005

Cited by 65 publications

(64 citation statements)

References 8 publications

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“…In a retrospective cohort study of 136 kidney transplant recipients, 56 developed UTIs, and the most commonly isolated microorganisms were E. coli (59.1%) and Klebsiella spp. (16.9%) (4) . In another retrospective cohort study of 393 kidney transplant recipients, 221 UTI episodes were reported, and the most commonly reported microorganisms were E. coli (18.4%) and Klebsiella spp.…”

mentioning

confidence: 99%

Study of the risk factors related to acquisition of urinary tract infections in patients submitted to renal transplant

Menegueti

Pereira

Bellissimo-Rodrigues

et al. 2015

Rev. Soc. Bras. Med. Trop.

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mentioning

confidence: 99%

Study of the risk factors related to acquisition of urinary tract infections in patients submitted to renal transplant

Menegueti

Pereira

Bellissimo-Rodrigues

et al. 2015

Rev. Soc. Bras. Med. Trop.

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“…micóticas, la tasa de infección bacteriana tuvo mayor incidencia durante el primer año post trasplante, cursando con oscilaciones anuales de 18% a 64%, siendo la ITU la localización más frecuente (73%) seguida del tracto respiratorio (7%). Al igual que en otras series, la ITU bacteriana representa la complicación más común de infecciones post trasplante renal y en porcentajes que fluctúan entre 16% a 79% (3,5,(9)(10)(11)(12)(13) , amplitud debida probablemente a la falta de criterio úni- Se ha demostrado que la vejiga de los pacientes con enfermedad renal cróni-ca terminal está colonizada por diversos patógenos (15) , predisponiendo al riesgo de infecciones urinarias hasta cuatro veces mayor en el post trasplante (16) , aun cuando la frecuencia global de ITU experimentó declinación gracias a la mejor técnica quirúrgica y adecuada profilaxis antimicrobiana (17) . En nuestra investigación, 42 (50%) de los 84 receptores inició episodios de ITU durante los primeros tres meses del post trasplante y mayormente durante el primer mes (figura 1), con porcentaje alto como si el paciente no hubiese recibido profilaxis antibióti-ca (10) .…”

Section: Discussionunclassified

“…Los casos con fuga urinaria fueron sometidos a reimplante ureteral y, los de estrechez, a medidas endourológicas con inserción de stent. A propósito, se reporta que los stents ureterales incrementan 4 veces la presencia de ITU (7,12,13,22) y se señala que aun después de su remoción pueden quedar nidos de infección residual (13) . Por tanto, el pronto retiro (32,34,35) es la indicación apropiada.…”

Section: Discussionunclassified

Infección del tracto urinario en receptores de trasplante renal

et al. 2017

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Introducción. La infección del tracto urinario (ITU) es común en receptores de trasplante renal (TR). La frecuencia de ITU depende de factores previos y posteriores al trasplante. Objetivos. Determinar la cronología de aparición de ITU sintomática, los microorganismos causantes y la incidencia de ITU resistente a antibióticos en receptores de TR. Diseño. Estudio retrospectivo. Lugar. Unidad de Trasplante Renal, Hospital Edgardo Rebagliati Martins, EsSalud, Lima, Perú. Participantes. Pacientes sometidos a TR. Intervenciones. Se revisó la historia clínica de 304 pacientes sometidos a TR en el período 2002-2011, con seguimiento de hasta cuatro años por paciente. Se constató 215 episodios de ITU sintomática confirmada mediante urocultivo en 84 receptores. Principales medidas de resultados. Incidencia, cronología, determinación microbiológica/ susceptibilidad, resistencia bacteriana, factores de riesgo, estrategias diagnósticas, presencia o no de bacteriemia y manejo terapéutico. Resultados. En 50% de los 84 receptores el episodio inicial ocurrió durante los primeros tres meses, y en 39% se constató más de un episodio de ITU. Las bacterias representaron la etiología más frecuente (94%), siendo la Escherichia coli (77%) el uropatógeno prevalente, con tasa productora betalactamasa espectro extendido (BLEE) en 38%, seguida de Klebsiella pneumonie (11%) con BLEE 65%. En 12% de los 215 episodios de ITU el hemocultivo fue positivo. Entre los factores de riesgo se detectó luego del trasplante 19% receptores con anormalidades anatómicas del tracto urinario. Conclusiones. La ITU ocurrió tempranamente luego del trasplante y la Escherichia coli fue el microorganismo etiológico más frecuente. La resistencia antibiótica estuvo presente en 37% de los 215 episodios de ITU, representando un desafío contínuo a resolver en la práctica clínica.

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“…The onset of bacterial UTIs post-renal transplant has been reported by many studies, but as in the case of reported rates of infection, a consensus has not been reached. There are numerous reports stating that UTIs occur most commonly with the first three to six months [7][8][9][10] following transplant, while many others show that the highest incident for UTIs is one month post-transplant [3,11,12]. RTRs have multiple risk factors for acquiring UTIs post-renal transplant.…”

Section: Introductionmentioning

confidence: 99%

“…It has also been shown that catheterization for longer than two days is an important risk factor [17]. Additionally, female gender has been cited frequently as another risk factor [3,7,14,18,19]. Due to the relatively high rates and serious consequences of bacterial UTIs in renal transplant recipients in addition to the fact that RTRs are immunocompromised, it is important to implement an antibacterial prophylaxis regimen in renal transplant programs.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the effectiveness of antibacterial prophylaxis in renal transplant recipients

Alkatheri

Albekairy

Alharbi

et al. 2014

J Infect Dev Ctries

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Introduction: Bacterial urinary tract infections (UTIs) are very common complications in renal transplant recipients (RTRs). Methodology: This study is a follow-up to a previous investigation of post-renal transplant UTIs, which led to changes in the antibacterial agents used for prophylaxis and its duration. In this retrospective study of the medical records of 86 RTRs, the incidence, risk factors, causative bacteria, and duration prophylaxis were investigated. Results: The average age of the RTRs was 41.55 ± 14.06 years, and two-thirds of them were males. A total of 57.3% of the RTRs received cadaveric kidneys; the rest received kidneys from living related donors. The prescribed regimen (one month or three months of cotrimoxazole and norfloxacin) was completed by 75% of the RTRs. The incidence of UTIs in the RTRs who received this prophylaxis was 32.3%, which was significantly lower than the incidence with norfloxacin alone (56%). Female gender was found to be a risk factor for postrenal transplant UTIs. Escherichia coli was the most common pathogen (51.7%), followed by Klebsiella and Enterobacter (17.2% each). Most UTIs (86.2%) were detected within the first post-transplant month. Conclusions: There was no clear advantage to prescribing antibacterial prophylaxis for three months versus one month, as 86.2% of the UTIs occurred within the first month post-transplant regardless of prophylaxis duration. Using co-trimoxazole/norfloxacin compared to norfloxacin alone did positively affect patient outcome by reducing the incidence of UTIs. This study recommends antimicrobial sensitivity-guided modification of the antibacterial agents used for prophylaxis rather than extension of its duration.

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Urinary Tract Infections Following Renal Transplantation: A Single-Center Experience

Cited by 65 publications

References 8 publications

Study of the risk factors related to acquisition of urinary tract infections in patients submitted to renal transplant

Study of the risk factors related to acquisition of urinary tract infections in patients submitted to renal transplant

Infección del tracto urinario en receptores de trasplante renal

Investigation of the effectiveness of antibacterial prophylaxis in renal transplant recipients

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