Urinary xylose excretion in steatorrhoea

Shiner, Margot; Vakil, B. J.; Wilcox, Pamela B.

doi:10.1136/gut.3.3.240

Cited by 15 publications

(2 citation statements)

References 12 publications

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“…Using the results of Stewart, Pollock, Hoffbrand, Mollin, and Booth (1967), Finlay and Wightman (1958), Benson, Culver, Ragland, Jones, Drummey, and Bougas, (1957), Gardner and Santiago (1956), Christiansen, Kirsner, and Ablaza (1959), and Shiner, Vakil, and Wilcox (1962), in combination with results for the intravenous test in young subjects found in the present study, the calculated xylose absorption test ratio in patients with either coeliac disease or tropical sprue would be 0-6 to 1 2 with a weighted mean of 11. IHowever, only 7% of the elderly subjects studied in this series had a ratio of less than 1 2.…”

Section: Dmentioning

confidence: 59%

Assessment of small bowel function in the elderly using a modified xylose tolerance test.

Webster¹,

Leeming²

1975

Gut

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SUMMARY Using the combined results of oral and intravenous xylose tests, it is demonstrated that 26% of a group of geriatric patients absorb from the small bowel less efficiently than younger subjects.The method used excludes poor renal function and incomplete bladder emptying as possible causes for the differences found between the two age groups. Altered gastric emptying is also excluded as a possible factor. Phillips and Gilder (1940) reported reduced absorption of dextrose in aged rats when direct measurements were made on luminal residues after an oral load. In man, Meyer, Sorter, Oliver, and Necheles (1943) were probably the first workers to present evidence suggestive of impaired small bowel function in the elderly in relation to theabsorptionofmonosaccharides. Their findings were based on the results of observing blood galactose levels in elderly subjects after oral ingestion of galactose. Although slow removal of galactose from the subjects' blood could account for the differences between their young and elderly groups, the initial low levels found only in the elderly could have been caused by the impaired absorption of the monosaccharide.Guth (1968), using similar reasoning to Meyer et al, concluded from the xylose tests that he performed that small bowel absorption was impaired in the elderly. (However, both groups' conclusion can be criticized, as impaired renal function was not actively excluded and could therefore be influencing their results.) Davies and Shock (1950), Dontas (1963), and Friedman, Raizner, Rosen, Solomon, and Sy (1972 all clearly demonstrated by different methods the frequency of renal functional impairment with increasing age.Sapp, Seasions, and Rose (1964) and Fikry and Aboul-Wafa (1965) attempted to exclude elderly subjects with subnormal renal function from their studies on the effects of age on the standard xylose test, and found a decrease in urinary recovery of the substance after an oral dose.

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Section: Dmentioning

confidence: 59%

Assessment of small bowel function in the elderly using a modified xylose tolerance test.

Webster¹,

Leeming²

1975

Gut

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“…A few investigators have tried to correlate the changes in the absorption pattern to the distribution of the lesions in the intestine, but the number of patients studied has been small and the results have been to some extent controversial (2,11,12). In ulcerative colitis malabsorption of fat and vitamin B,, has been reported by Salem et al (10) and Jalan et al (6).…”

mentioning

confidence: 99%

Absorption Studies in Patients With Crohn's Disease and in Patients With Ulcerative Colitis

Andersson

Dotevall

Gillberg

et al. 1971

Journal of Internal Medicine

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Abstract. Absorption studies were carried out in 52 patients with Crohn's disease and in 25 patients with ulcerative colitis. Vitamin B12 in serum and folate in serum and whole blood were determined. Absorption of D‐xylose, fat and vitamin B12 were studied. The patients with Crohn's disease were divided into three groups with respect to the localization and extension of the lesions. Subnormal values of D‐xylose excretion were found in 14 out of 52 patients with Crohn's disease but without preference for any of the groups. Malabsorption of fat was common both in patients with Crohn's disease and in patients with ulcerative colitis. In all patients with extensive involvement of Crohn's disease in the small bowel fat absorption was impaired. Abnormally low absorption of vitamin B12 (Schilling test below 5%) was noted predominantly in patients who had previously undergone small bowel resection for Crohn's disease.

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Remediable Defects in Crohn Disease

Beeken¹

1975

Arch Intern Med

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Urinary xylose excretion in steatorrhoea

Cited by 15 publications

References 12 publications

Assessment of small bowel function in the elderly using a modified xylose tolerance test.

Assessment of small bowel function in the elderly using a modified xylose tolerance test.

Absorption Studies in Patients With Crohn's Disease and in Patients With Ulcerative Colitis

Remediable Defects in Crohn Disease

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