Urotensin-II expression in the mouse spinal cord

Egginger, Johann-Günther; Camus, A.; Calas, A.

doi:10.1016/j.jchemneu.2005.10.004

Cited by 19 publications

(13 citation statements)

References 33 publications

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“…http://jme.endocrinology-journals.org DOI: 10.1530/JME-13-0274 (Chartrel et al 1998, Coulouarn et al 1998, 1999, Dun et al 2001, Pelletier et al 2002, Egginger et al 2006. Notably, UII mRNA is detected early in the formation of the rat embryonic ventral neural tube, at a developmental stage coincident with the differentiation of motor neurons (Coulouarn et al 2001).…”

Section: Journal Of Molecular Endocrinologymentioning

confidence: 99%

“…The highest levels of expression of the UII gene are found in the CNS, specifically in motor neurons (Chartrel et al 1998, Coulouarn et al 1998, 1999, Dun et al 2001, Pelletier et al 2002, Egginger et al 2006. However, the bulk of all research into the UII-ergic system has mainly focused on the peripheral effects as the receptor is expressed predominantly in the periphery, in the cardiorenal system (Tal et al 1995, Ames et al 1999, Matsushita et al 2001, Elshourbagy et al 2002.…”

Section: Uts2r5mentioning

confidence: 99%

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MOLECULAR EVOLUTION OF GPCRS: Somatostatin/urotensin II receptors

Tostivint¹,

Daza²,

Bergqvist³

et al. 2014

Journal of Molecular Endocrinology

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Somatostatin (SS) and urotensin II (UII) are members of two families of structurally related neuropeptides present in all vertebrates. They exert a large array of biological activities that are mediated by two families of G-protein-coupled receptors called SSTR and UTS2R respectively. It is proposed that the two families of peptides as well as those of their receptors probably derive from a single ancestral ligand-receptor pair. This pair had already been duplicated before the emergence of vertebrates to generate one SS peptide with two receptors and one UII peptide with one receptor. Thereafter, each family expanded in the three whole-genome duplications (1R, 2R, and 3R) that occurred during the evolution of vertebrates, whereupon some local duplications and gene losses occurred. Following the 2R event, the vertebrate ancestor is deduced to have possessed three SS (SS1, SS2, and SS5) and six SSTR (SSTR1-6) genes, on the one hand, and four UII (UII, URP, URP1, and URP2) and five UTS2R (UTS2R1-5) genes, on the other hand. In the teleost lineage, all these have been preserved with the exception of SSTR4. Moreover, several additional genes have been gained through the 3R event, such as SS4 and a second copy of the UII, SSTR2, SSTR3, and SSTR5 genes, and through local duplications, such as SS3. In mammals, all the genes of the SSTR family have been preserved, with the exception of SSTR6. In contrast, for the other families, extensive gene losses occurred, as only the SS1, SS2, UII, and URP genes and one UTS2R gene are still present.

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Section: Journal Of Molecular Endocrinologymentioning

confidence: 99%

Section: Uts2r5mentioning

confidence: 99%

MOLECULAR EVOLUTION OF GPCRS: Somatostatin/urotensin II receptors

Tostivint¹,

Daza²,

Bergqvist³

et al. 2014

Journal of Molecular Endocrinology

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show abstract

“…Reciprocally, the UII gene, but not the URP gene, is expressed in the medial vestibular nucleus . In mouse and rat, UII is expressed in a subset of spinal motoneurons, the density of UII-positive neurons being higher in the lumbar and sacral regions than in the cervical segment (Coulouarn et al, 1998(Coulouarn et al, , 1999Ames et al, 1999;Dun et al, 2001;Pelletier et al, 2002Pelletier et al, , 2005Egginger et al, 2006;Dubessy et al, 2008). A majority of mouse spinal motoneurons simultaneously express UII Urotensin II and Its Receptor and URP mRNAs as well as androgen receptor mRNA (Pelletier et al, 2005).…”

Section: F the Urotensin II And Urotensin Ii-related Peptide Genesmentioning

confidence: 99%

International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, Urotensin II–Related Peptide, and Their Receptor: From Structure to Function

et al. 2014

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“…UII has been identified as the endogenous ligand for the orphan G protein-coupled receptor, GPR 14 (urotensin II receptor, UT) [2,3] . UII mRNA is predominately expressed in the spinal cord and certain brain areas, while UT mRNA is widely expressed in cardiovasculature such as the myocardium, vascular smooth muscle cells (VSMC) and endothelial cells [4,5] . Human UII effectively constricts isolated arteries from non-human primates.…”

Section: Introductionmentioning

confidence: 99%