Use of a new olive oil-based emulsion as an alternative to soy based emulsions in long term TPN: favorable effects on plasma fatty acid profiles

Trimbo, Susan; Colin, R; Paris, Jacqueline; Guédon, Claire; Lescut, D.; Béréziat, G.; Driss, Fathi; Rössle, C.; Dutot, G.; Brun, A. Le; Pérennec, V.; Mélin, C.

doi:10.1016/0261-5614(93)90250-8

Cited by 8 publications

(6 citation statements)

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“…Despite a low content of PUFAs compared with Intralipide 20% or Medialipide 20%, and the subsequent decrease in linoleic and α ‐linolenic acids provision, its prolonged administration did not alter EFAs status as assessed by the normality of the triene:tetraene ratio. This result confirms previous data in short‐ and long‐term administration in paediatric patients 6, 7 or short‐term use in adults 34, 35 . By contrast to Goulet et al.…”

Section: Discussionsupporting

confidence: 92%

Efficacy and safety of an olive oil‐based intravenous fat emulsion in adult patients on home parenteral nutrition

Reimund

Rahmi

Escalin

et al. 2005

Aliment Pharmacol Ther

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SUMMARY Background:The most frequently used intravenous lipid emulsions are composed of 100% long chain triacylglycerols from soybean oil or of 50% long chain triacylglycerols-50% medium chain triacylglycerols. A newer emulsion, ClinOleic 20% containing 80% olive oil and 20% soybean oil, was suggested to reduce lipid peroxidation and immune function impairment. Aim: To assess ClinOleic 20%'s efficacy, safety and effect upon systemic inflammatory parameters in adults on home parenteral nutrition. Methods: In stable home parenteral nutrition patients, the initial intravenous lipid emulsion was changed for ClinOleic 20%. Nutritional status, clinical and biological tolerance, and systemic inflammatory markers were

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Section: Discussionsupporting

confidence: 92%

Efficacy and safety of an olive oil‐based intravenous fat emulsion in adult patients on home parenteral nutrition

Reimund

Rahmi

Escalin

et al. 2005

Aliment Pharmacol Ther

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“…The w-3 family has the higher affinity, and the higher amount administered with the structured, LCT, and MCT/LCT emulsions in relation to oleic emulsion could justify our results. The increase in intermediary metabolites of linoleic acid (C18:3 w-6 and C20:3 w-6) observed in the oleic group, which was already reported in premature babies, 12 burn patients, 20 and patients after 3 months of receiving home PN 35 with the same emulsion, suggests that a lower supply of PUFAs favors ∆-6 desaturation as well as linoleic acid elongation. The ratio of linoleic acid:w-6 PUFAs is a good index expressing the conversion of linoleic acid to its metabolites.…”

Section: Fatty Acid Patternsupporting

confidence: 55%

Evolution of Lipid Profile, Liver Function, and Pattern of Plasma Fatty Acids According to the Type of Lipid Emulsion Administered in Parenteral Nutrition in the Early Postoperative Period After Digestive Surgery

Puiggròs¹,

Sánchez²,

Chacón³

et al. 2009

J Parenter Enteral Nutr

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“…However, we found a higher concentration of C18:3n‐6 and C20:3n‐6 after 7 days' administration of the olive oil emulsion compared with the soybean oil emulsion, which is compatible with an enhanced Δ‐6‐desaturation and elongation of LA in group O. The reduced values of AA and of total n‐6 metabolites observed in both groups is in contrast to other studies in older children (19) and in adults (20), who showed a decrease of LCP only with S and no change with O. The AA decrease in the S group observed in this study is similar to that reported in preterm infants by Rubin et al (2) (−27%) after soybean oil infusion.…”

Section: Discussioncontrasting

confidence: 67%

Parenteral Fat Emulsions Based on Olive and Soybean Oils: A Randomized Clinical Trial in Preterm Infants

Göbel,

Koletzko,

Böhles

et al. 2003

J. pediatr. gastroenterol. nutr.

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ObjectiveTo evaluate in premature infants a new parenteral lipid emulsion based on olive and soybean oils (ratio 4:1), with less polyunsaturated fatty acids (PUFA) and more α‐tocopherol than standard soybean oil emulsion.Study designPremature infants (gestational age, 28–<37 weeks) were randomized to receive one of the two emulsions within the first 72 hours of life. The triglyceride dose was increased to 2 g/kg/day within 3 days. Plasma phospholipid fatty acids, α‐tocopherol/lipid ratio, and urinary malondialdehyde (MDA) excretion were determined at baseline and after 7 days.ResultsOf 45 recruited infants, 33 completed the study per protocol (15 soybean oil, 18 olive oil emulsion). At study end, groups did not differ in plasma phospholipid arachidonic acid, total n‐6 and n‐3 metabolites, but the olive oil group showed higher values of the PUFA intermediates C18:3n‐6 (0.19% ± 0.01% vs. 0.13% ± 0.02%, P < 0.05) and C20:3n‐6 (2.92% ± 0.12% vs. 2.21% ± 0.17%, P = 0.005). The plasma α‐tocopherol/total lipd ratio was higher in the olive oil group (2.45 ± 0.27 μmol/mmol vs. 1.90 ± 0.08 μmol/mmol, P = 0.001), whereas urinary MDA excretion did not differ.ConclusionThe lower PUFA supply with the olive/soybean oil emulsion appears to enhance linoleic acid conversion. The reduced PUFA content, combined with a higher antioxidant intake in the olive oil group, results in an improved vitamin E status. The olive oil‐based emulsion is a valuable alternative for parenteral feeding of preterm infants who are often exposed to oxidative stress, while their antioxidative defense is weak.

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Use of a new olive oil-based emulsion as an alternative to soy based emulsions in long term TPN: favorable effects on plasma fatty acid profiles

Cited by 8 publications

References 0 publications

Efficacy and safety of an olive oil‐based intravenous fat emulsion in adult patients on home parenteral nutrition

Efficacy and safety of an olive oil‐based intravenous fat emulsion in adult patients on home parenteral nutrition

Evolution of Lipid Profile, Liver Function, and Pattern of Plasma Fatty Acids According to the Type of Lipid Emulsion Administered in Parenteral Nutrition in the Early Postoperative Period After Digestive Surgery

Parenteral Fat Emulsions Based on Olive and Soybean Oils: A Randomized Clinical Trial in Preterm Infants

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