Use of a novel polyvinyl alcohol membrane as a pericardial substitute reduces adhesion formation and inflammatory response after cardiac reoperation

Abstract

The PVAM shows promising properties for its potential use as a novel pericardial substitute.

Gelatin/Polycaprolactone Electrospun Nanofibrous Membranes: The Effect of Composition and Physicochemical Properties on Postoperative Cardiac Adhesion

“…Among the strategies adopted to prevent postoperative cardiac adhesions (e.g., pharmacological intervention ( Lopes et al, 2009 ) or physical barriers ( de Oliveira et al, 2014 )), using biomaterial-based membranes is believed to be the most promising one. Expanded polytetrafluoroethylene (ePTFE) is possibly the most extensively utilized and evaluated membrane used to prevent postoperative cardiac adhesion ( Minale et al, 1988 ; Jacobs et al, 1996 ), but it has not been routinely applied in clinic due to certain shortages such as non-degradability, chronic foreign-body reactions, and predispose to infection over time ( Ozeren et al, 2002 ; Tsukihara et al, 2006 ).…”

Evaluation of polylactide film for prevention of pericardial adhesion in a rabbit model

“…However, this needs to occur without an increase in the tendency towards infection. [8,[11][12][13][14][15][21][22][23] In spite of efforts to find an appropriate barrier, no satisfactory substitute has been found so far.…”

“…Recent studies have focused on bioabsorbable materials because nonabsorbable barriers can cause a long-term foreign body reaction that can lead to an increased risk of infection and fibrosis development that obscures the view of the cardiac anatomy during a reoperation. Successful results have also been reported in animal models with hyaluronic acid-carboxymethylcellulose, [8][9][10] polyvinyl alcohol, [11] and collagen membranes, [12] as well as fibrin sealant patches. [13] The role of polylactic acid (PLA)-based bioabsorbable membranes in the prevention of abdominal adhesions is widely known.…”

Advanced postoperative tissue antiadhesive membranes enabled with electrospun nanofibers

“…168 Currently, numerous materials have been developed for the prevention of pericardial adhesions, such as expanded polytetrafluoroethylene (e-PTFE) and bioabsorbable membranes (Seprafilm). 166,169 However, the e-PTFE membranes tend to cause severe inflammation due to their non-biodegradability and the bioabsorbable membranes degrade too quickly in vivo. 170,171 Thus, the construction of new types of pericardial anti-adhesin materials is urgent.…”