Use of a platelet-rich fibrin membrane to repair traumatic tympanic membrane perforations: a comparative study

Gür, Özer Erdem; Ensari, Nuray; Öztürk, Mehmet Türker; Boztepe, Osman Fatih; Gün, Taylan; Selçuk, Ömer Tarık; Renda, Levent

doi:10.1080/00016489.2016.1183042

Cited by 43 publications

(23 citation statements)

References 18 publications

(50 reference statements)

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“…For instance, gelatin sponge, basic fibroblast growth factor, and sea buckthorn oil have shown the ability to facilitate the healing of TM perforations 12–14. These agents can promote epithelial cell proliferation and cell–cell connection, consequently accelerating the repair of perforations and improving hearing.…”

Section: Discussionmentioning

confidence: 99%

Management of traumatic tympanic membrane perforation: a comparative study

Gao¹,

Li²,

Hu³

et al. 2017

TCRM

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This prospective study was conducted to evaluate the efficacy of sea buckthorn oil patches in treating traumatic tympanic membrane (TM) perforations. We enrolled 370 patients with traumatic TM perforations of different sizes. These patients were randomly assigned to control group and treatment group. In the treatment group, a sterile cotton patch with sea buckthorn oil was used to cover the TM perforations. In the control group, patients were treated with a sterile cotton patch. The healing rate and time were compared between the two groups. We found that the overall healing rate was significantly higher in the treatment group than in the control group. For middle and large TM perforations, sea buckthorn oil treatment led to a significant increase in the healing rate. At 2 months after injury, the duration of healing was, generally, shorter in the treatment group than in the control group (P<0.05). In conclusion, sea buckthorn oil patches are effective in treating middle and large TM perforations, which results in increased healing rates and decreased healing time.

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Section: Discussionmentioning

confidence: 99%

Management of traumatic tympanic membrane perforation: a comparative study

Gao¹,

Li²,

Hu³

et al. 2017

TCRM

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“…Gur et al, [14] compared the use of a PRF membrane versus the use of paper patch as regards healing time, recovery rates, and the mean air bone gap correction.…”

Section: Methodsmentioning

confidence: 99%

“…Experimentally, Ensari et al, [16] evaluated with Gür et al, [14] who reported that the mean age of patients with traumatic TM perforation was 28.9 years. Lindeman et al,…”

Section: Methodsmentioning

confidence: 99%

Use of Platelet Rich Fibrin in Acute Traumatic Tympanic Membrane Perforation Compared With the Conservative Treatment

Shindy

El-Shimi

Belal

et al. 2020

Benha Medical Journal

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Objectives: To evaluate the effect of platelet rich fibrin in treating acute traumatic tympanic membrane perforation as regards wound healing and hearing outcome compared with conservative treatment. Methods: This study was conducted on 50 patients presented with acute traumatic tympanic membrane perforation classified randomly into 2 groups: the study group; (25 patients) treated with platelet rich fibrin membrane and control group; (25 patients) underwent conservative treatment. Patients were followed up for 6 weeks to assess healing rate of the tympanic membrane perforation and hearing improvement. Results: In the group where platelet rich fibrin was used, complete perforation closure occurred in 88% of patients, while in the group treated conservatively, closure was obtained in 56% (P 0.004). The mean air bone gap improved in the platelet rich fibrintreated group from 18.83±3.99 dB to 3.38±4.13 dB and in the control group from 18.90±3.43 dB to 9.84±8.04 dB. The post-treatment mean air bone gap significantly improved better in the platelet rich fibrintreated group than in the control group (P 0.004). Hearing gain by >10 dB was obtained in 88% of patients in the platelet rich fibrin group and in 44% of patients in the control group (P 0.001). Conclusion: In comparison with the conservative management, platelet rich fibrin, as an autologus simple graft method, provided more healing rates with better audiological outcomes with low cost and no complications.

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“…PRF could easily be compressed into PRF membrane, by pressing the PRF clot between two pieces of surgical gauze [41,44]. PRF membrane has been successful in oral mucosal defects [44,46], periodontal bone defects [41,47], gingival recession defects [42], and tympanic membrane perforation [48]. PRF membrane offers acceptable elasticity and may stretch to some extent to cover wound edges, but it lacks rigidity and needs to be carefully handled to prevent tearing [41,44].…”

Section: Platelet Rich Fibrinmentioning

confidence: 99%

New Resorbable Membrane Materials for Guided Bone Regeneration

2018

Applied Sciences

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Membranes are used for guided bone regeneration (GBR) in bone defects. Resorbable membranes of collagen or aliphatic polyesters that do not require secondary surgery for removal, unlike non-resorbable membranes, have been marketed for GBR. Platelet rich fibrin membrane and silk-based membranes have recently been assessed as membranes for GBR. Studies have been conducted on resorbable membranes with new materials to improve physical properties and bone regeneration without any adverse inflammatory reactions. However, clinical research data remain limited. More studies are needed to commercialize such membranes.

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Use of a platelet-rich fibrin membrane to repair traumatic tympanic membrane perforations: a comparative study

Abstract: In comparison with the paper patch method, PRF, a new method, provided more rapid healing with more successful audiological results, and with no requirement for a second procedure.

Cited by 43 publications

References 18 publications

Management of traumatic tympanic membrane perforation: a comparative study

Management of traumatic tympanic membrane perforation: a comparative study

Use of Platelet Rich Fibrin in Acute Traumatic Tympanic Membrane Perforation Compared With the Conservative Treatment

New Resorbable Membrane Materials for Guided Bone Regeneration

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