Use of cyanoacrylate to prevent cerebrospinal fluid fistulas after cranial surgery

Abstract

CA can help dural repair against the development of CSF fistula by taking effect quickly. Also, it is a rapid anti-haemorrhagic agent. It can also be used after posterior fossa surgery, skull base surgery where dural repair is difficult, or during sinus repair.

Alaska Pollock-derived Gelatin Sealant has Higher Sealing Strength than, and Comparable Biocompatibility with, Fibrin Sealant in Porcine and Rat Dural Injury Models

“…Many previous studies have used fibrin sealant for CSF leakage and showed the effectiveness of dura mater sealing; however, a disadvantage of fibrin sealant is its lack of sealing strength 1,2,5 . Other adhesives such as cyanoacrylate and biopolymers with aldehyde-based crosslinkers are used because of their high bonding strength 6–9 . However, the use of these materials is limited owing to their cytotoxicity and low biocompatibility 4,9 …”