Use of FAB MS/MS for analysis of quarternary amine pesticide standards

Abstract

Short CommunicationDear S i r Use of FAB MS/MS f o r A n a l y s i s of Q u a r t e r n a r y Amine P e s t i c i d e S t a n d a r d s The U .S. Environmental P r o t e c t i o n Agency m a i n t a i n s a q u a l i t y a s s u r a n c e

Tandem mass spectrometric analysis of quaternary ammonium pesticides

“…Castro et al 7 analysed the five quats by ion‐pair HPLC/API‐MS, comparing ES and APCI. They used in‐source collision induced dissociation (CID) to generate product ions, and found many of these corresponded with those reported from FAB‐MS/MS3 and CE‐MS/MS studies 10. To date, MS/MS studies have concentrated only on the major product ions and many of the weaker transitions remain unassigned.…”

“…Since MQ + also fragments to yield m/z 58,7 the use of specific trapping conditions is appropriate for its analysis. By contrast, the monocations of DF, DQ and PQ produce fragment ions of sufficiently high m/z values3,, 10 to exhibit stable trajectories within a trap operated under standard conditions. Clearly, however, due to the nature of the trap, their relative and absolute abundances may not be optimised.…”

“…Previous reports of MS analysis of quats have employed thermospray,2 fast atom bombardment (FAB)3 and atmospheric pressure ionisation (API)4–10 interfaces, typically in combination with separation by either high performance liquid chromatography (HPLC)2,, 4 – 7 or capillary electrophoresis (CE) 810 Generally, these reports concentrate either on detection of the quaternary ammonium cation (M q + ) or, using tandem mass spectrometry (MS/MS), on selected reaction monitoring (SRM) of a characteristic transition.…”

Ion-trap versus quadrupole for analysis of quaternary ammonium herbicides by LC-MS

“…To overcome these drawbacks, mass spectrometry is used because it is specific and sensitive. Some papers report FAB/MS [17,18], CE-MS [19][20][21] and LC-MS [22 24] for the analysis of quats, but most used quadrupolar (Q) systems. We have recently proposed an ion-pair LC-MS method [25,26] for the determination of quats in water samples using a single quadrupole instrument (VG Platform II).…”

Fragmentation patterns of novel dispirocyclopiperazinium dibromides with strong analgesic activity under electrospray ionization tandem mass spectrometry conditions

“…Mass spectrometry (MS) has become the analytical method for quaternary ammonium salts owing to its high specificity and sensitivity. Previous reports on MS analysis of quaternary ammonium pesticides (quats) have employed thermospray,16 fast atom bombardment (FAB),17 and atmospheric pressure ionization (API) 18–23. Generally, these reports focus either on detection of the quaternary cation (M q + ), or on selected reaction monitoring (SRM) of a characteristic transition using tandem mass spectrometry (MS/MS).…”