Use of Honey as an Adjunct in the Healing of Split-Thickness Skin Graft Donor Site

Misirlioğlu, Aykut; Eroglu, Sinem; Karacaoğlan, Naci; Akan, Mi̇that; Aköz, Tayfun; Yıldırım, Serkan

doi:10.1046/j.1524-4725.2003.29043.x

Cited by 38 publications

(30 citation statements)

References 14 publications

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“…These demonstrate that positive results achieved with honey are not just a placebo effect. One of these was a prospective randomised controlled trial of honey on split-thickness skin graft donor sites 24 (the last item in Table 1). On patients in this trial who had single donor sites (three groups of 14 patients), half of the donor site was treated with honey and half with the comparative treatment.…”

Section: Discussionmentioning

confidence: 99%

The Evidence Supporting the Use of Honey as a Wound Dressing

Molan

2006

The International Journal of Lower Extremity Wounds

389

302

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Some clinicians are under the impression that there is little or no evidence to support the use of honey as a wound dressing. This impression is reinforced by it being concluded in systematic reviews that the evidence is not of a high standard. But likewise the evidence for modern wound dressing products is of not of a high standard. For evidence-based medicine to be practised in wound care, when deciding which product to use to dress a wound it is necessary to compare the evidence that does exist, rather than be influenced by advertising and other forms of sales promotion. To allow sound decisions to be made, this review has covered the various reports that have been Key words: evidence, honey, infected wounds, surgical wounds, burns, ulcers, abscesses, skin grafts, moist dressings, non-stick, debriding, deodorising, antibacterial, anti-inflammatory, prevention of scarring 3 There is a rapidly increasing interest in the use of honey as a wound dressing, but it is common to hear clinicians express the opinion that there is no evidence to support the use of honey as a wound dressing. However, the impression upon which this opinion is based is most likely to be a reflection of the scarcity of advertising and other commercial promotion of honey for wound care relative to that of other wound care products. Even where reviews of clinical evidence for the use of honey have been published, a negative impression is often obtained from consulting these, as the conclusions stated are that the evidence is of low quality and/or that there is a need for more evidence.1-6 But the myriad of advertisements for modern wound dressings possibly blinds people to the fact that only small, poor-quality trials exist to support the use of these products. The literature cited was found by searching the PubMed, BIOSIS and ISI Web of Science databases for the term "honey". Also, literature not included in the databases was found from citations in papers that were. Excluded were papers where honey was used in a mixture with other therapeutic substances, papers giving brief reports on the use of honey on cases where there was insufficient information on the cases given for the reader to judge if the positive outcomes were the result of honey being more effective than the prior treatment, and papers that were expressions of opinion rather than reports of treatment of wounds with honey. Conference presentations were also excluded. CLINICAL EVIDENCE 4Many randomised controlled trials have been carried out comparing honey with various other wound treatments. These trials and the results obtained from them are summarised in Table 1. Other clinical trials have been conducted where the form of the trial has been other than a randomised controlled trial. In some of these the results for

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Section: Discussionmentioning

confidence: 99%

The Evidence Supporting the Use of Honey as a Wound Dressing

Molan

2006

The International Journal of Lower Extremity Wounds

389

302

View full text Add to dashboard Cite

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“…In this trial, honey was compared with 3 controls, saline-soaked gauze, paraffin gauze, and a hydrocolloid. The significantly faster healing rate and lower pain scores achieved with honey compared with saline-soaked gauze and paraffin gauze clearly would have been due to physical effects of the honey and not to psychosomatic effects [30] . In a randomized controlled trial published in 2007 by Jull, honey-impregnated dressings did not significantly improve venous ulcer healing at 12 weeks compared with usual care [45] .…”

Section: Discussionmentioning

confidence: 96%

“…Different authors argued that there was a need for more than one robust randomised controlled trial to support the use of honey [13][14][15]19] . Critically, a study evaluated the effectiveness of honey-impregnated gauzes, hydrocolloid dressings and saline-soaked gauze for the treatment of skin graft donor sites [30] . No significant difference was found between hydrocolloid and honey impregnated gauze with regard to time to healing and pain [30] .…”

Section: Discussionmentioning

confidence: 99%

“…Critically, a study evaluated the effectiveness of honey-impregnated gauzes, hydrocolloid dressings and saline-soaked gauze for the treatment of skin graft donor sites [30] . No significant difference was found between hydrocolloid and honey impregnated gauze with regard to time to healing and pain [30] . In this trial, honey was compared with 3 controls, saline-soaked gauze, paraffin gauze, and a hydrocolloid.…”

Section: Discussionmentioning

confidence: 99%

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Medical honey and the role in pediatric emergency wound management

Bittmann

Weissenstein²,

Villalon³

et al. 2018

J Pediatr Dis

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The use of complementary medical treatment in wound management has continued to grow throughout the world.There is a large body of evidence to support the use of honey as a wound dressing for a wide range of types of wounds.Clear guidelines for the use of honey in pediatric wound care do not exist. We present an update of present knowledge using honey as a form of complementary medicine in pediatric wound management.

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“…In addition, honey is said to be hygroscopic which means that it can draw moisture from the environment thereby leading to dehydration [10,11] low pH and high sugar content (osmolarity) can also prevent microbial growth [12]. The healing properties of honey can be attributed to the fact that it offers antibacterial activity against many organisms [13,14], maintains protective barrier to prevent other infection [15]. Honey has been shown to have in vivo activity and is suitable for the treatment of ulcers [16].…”

Section: Introductionmentioning

confidence: 99%

Study on Antibacterial Efficacy of Different Honey Types in Southwestern Nigeria Against Wound Associated Bacteria

Adeyemo¹,

Torimiro²,

Akinola³

et al. 2017

J Apither

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Aim:The study assessed and compared the antibacterial activities of different honey types in Southwest Nigeria. It also compared antibacterial potency of the honey with a standard antibiotic. This was with a view to ascertain and providing information on cheaper alternative potent antibacterial product of natural source as well to confirm the antibacterial efficacy of the honey in Southwest, Nigeria. Materials and Methods: The sensitivity testing of honey samples was determined using agar-well diffusion method. The minimum inhibitory concentration of honey samples was determined using broth tube dilution method. Minimum bactericidal concentration of honey samples was determined. The data obtained were analyzed with appropriate statistical methods. Results: The zone of inhibitions exhibited by all honey samples against the test bacteria ranged between 6 ± 0.0 and 30.7 ± 1.2 mm. The death rate ranges between 52.1% and 94.6% in the dark amber honey sample (H9) after 120 min of contact time at the same concentration. Conclusion: In this study, super dark amber honey shows the highest antimicrobial property which compared favorably with the standard antibiotic (streptomycin). This honey has shown to have a potent broad spectrum antibacterial activity. However, further studies are recommended to assess its practicality in terms of use in the clinical setting.

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Use of Honey as an Adjunct in the Healing of Split-Thickness Skin Graft Donor Site

Abstract: The use of honey-impregnated gauzes is effective, safe, and practical. Honey can be an alternative material for the split-thickness skin graft donor site treatment.

Cited by 38 publications

References 14 publications

The Evidence Supporting the Use of Honey as a Wound Dressing

The Evidence Supporting the Use of Honey as a Wound Dressing

Medical honey and the role in pediatric emergency wound management

Study on Antibacterial Efficacy of Different Honey Types in Southwestern Nigeria Against Wound Associated Bacteria

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