Infrared radiation has wavelengths between 780nm and 1000μm. It is well absorbed by living organisms and is perceived as heat. The mechanisms of action of infrared rays on humans are still little known, however their effects on living tissues are well known, particularly useful in the treatment of various diseases and disorders, in the reduction of wound healing times, in weight loss, in non-surgical body remodelling, in photo-rejuvenation, in muscle recovery, in improving sleep quality, in relaxation and in many other applications in medicine, non-invasive aesthetic medicine, beauty, fitness and wellness. This brief communication aims to provide an overview of the use of infrared and related devices in these fields of application, grouping them according to (1) medical applications, (2) non-invasive aesthetic medicine applications and beauty treatments and (3) for home wellness use.