Usefulness of [18F]fluorodeoxyglucose PET/CT for evaluating the PD-L1 status in nasopharyngeal carcinoma

Zhao, Liang; Zhuang, Yanzhen; Fu, Kang; Chen, Peiqiong; Wang, Yuhuan; Zhuo, Jianfang; Liao, Xin; Chen, Haojun; Qi, Lin

doi:10.1007/s00259-019-04654-4

Cited by 27 publications

(32 citation statements)

References 42 publications

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“…Hence, a new method is essential to obtain the status of PD-L1 and PD-L1-TILs in GC in a simple, non-invasive, and dynamic manner. In recent years, with the increasingly extensive study of PD-L1 in tumors, medical imaging methods have been used to predict the PD-L1 expression level [11,12]. Contrast-enhanced computed tomography (CT) is the conventional imaging modality for assessment of GC, which plays a pivotal role in staging and follow-up [2,13].…”

Section: Introductionmentioning

confidence: 99%

CT radiomics and morphological characteristics for predicting PD-L1 expression on tumor cells and tumor infiltrating lymphocytes in gastric cancer

Qiao

Liu

et al. 2021

Preprint

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Purpose To explore CT radiomics and morphological characteristics for predicting programmed cell death ligand 1 on tumor cells (PD-L1) and tumor infiltrating lymphocytes (PD-L1-TILs) status in gastric cancer (GC).Methods From March 2019 to October 2019, 101 patients identified with GC who underwent surgery at our hospital were enrolled in this study retrospectively. Radiomic features were extracted from regions of interest manually drawn on venous CT images. Besides, 4 morphological characteristics were evaluated. The signatures based on radiomics and morphological characteristics were built using multiple classifiers (Support Vector Machine [SVM], Naive Bayes [NB], Decision Trees, and Random Forest). Receiver operating characteristic (ROC) curve was performed to assess diagnostic efficiency.Results The adjacent adipose tissue (p=0.009) and numerous radiomic features (all p<0.05) differed significantly between GCs with different PD-L1 status. Six radiomic features showed significant differences between different PD-L1-TILs status (all p<0.05). The highest areas under the ROC curves (AUCs) of signatures generated by classifiers were 0.807 (SVM) and 0.729 (NB) for the prediction of PD-L1 and PD-L1-TILs status, respectively.Conclusion It was promising to predict PD-L1 status in GCs noninvasively using CT radiomics combined with morphological characteristics. It might help to improve clinical decision making with regard to immunotherapy. However, the prediction for PD-L1-TILs needs to be explored further.

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Section: Introductionmentioning

confidence: 99%

CT radiomics and morphological characteristics for predicting PD-L1 expression on tumor cells and tumor infiltrating lymphocytes in gastric cancer

Qiao

Liu

et al. 2021

Preprint

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“…Hence, it is crucial to develop a complementary imaging approach that clearly defines GTV, includes very small lesions, and excludes non-malignant diseases. As a functional molecular imaging modality, 18 F-fluorodeoxyglucose (FDG) PET/CT is the most widely used for oncological evaluation. Several studies have evaluated the impact of 18 F-FDG PET/CT in delineating GTV in oesophageal cancer patients, which showed promising promotion [7,8].…”

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confidence: 99%

“…As a functional molecular imaging modality, 18 F-fluorodeoxyglucose (FDG) PET/CT is the most widely used for oncological evaluation. Several studies have evaluated the impact of 18 F-FDG PET/CT in delineating GTV in oesophageal cancer patients, which showed promising promotion [7,8]. However, FDG uptake reflects glucose metabolism and cannot be used to differentiate inflammation from malignancy.…”

mentioning

confidence: 99%

“…However, FDG uptake reflects glucose metabolism and cannot be used to differentiate inflammation from malignancy. Therefore, the falsepositive uptake in inflamed peritumour tissue after surgery and radiotherapy may limit usage of 18 F-FDG PET/CT in differentiating inflammatory tissues from residual or recurrent tumours.…”

mentioning

confidence: 99%

“…Therefore, this study compared 68 Ga-FAPI and 18 F-FDG PET/CT in the detection of locally advanced oesophageal cancer and evaluated the usefulness of 68 Ga-FAPI PET/CT on GTV delineation for radiotherapy planning.…”

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confidence: 99%

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68Ga-fibroblast activation protein inhibitor PET/CT on gross tumour volume delineation for radiotherapy planning of oesophageal cancer

Zhao

Chen

et al. 2021

Radiotherapy and Oncology

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Background and purpose: To compare 68 Ga-fibroblast activation protein inhibitor (FAPI) and 18 F-FDG PET/ CT in imaging locally advanced oesophageal cancer, and evaluate the potential usefulness of 68 Ga-FAPI PET/CT on gross target volume (GTV) delineation aimed at radiotherapy planning for oesophageal cancer as compared with contrast-enhanced CT (CE-CT) and 18 F-FDG PET/CT. Materials and methods: Twenty-one patients with newly diagnosed oesophageal cancer who underwent both 18 F-FDG and 68 Ga-FAPI PET/CT scans were selected. GTVs of the primary tumours based on CE-CT (GTV CT ), PET/CT, and CE-CT plus PET/CT were delineated. Gross tumour lengths were measured by GTVs and endoscopy and recorded. Results: The 68 Ga-FAPI PET showed significantly higher radiotracer uptake than 18 F-FDG PET (median SUVmax 16.71 vs. 11.23; P = 0.002) in the primary tumours. SUV thresholds of FAPI Â20%, 30%, 40%, and FDG Â40% showed similar lesion lengths compared with that in endoscopic examination (P > 0.05). GTV CT demonstrated the largest volume (median: 48.80 mm 3 , range: 14.83-162.23 mm 3 ) than PET-based GTVs. For PET/CT-guided complementary contouring of GTV CT , four patients (19%) were increased by FAPI Â20% and 30%, two patients (9.5%) were increased by FAPI Â40%, and only one patient was increased by FDG Â40%. Furthermore, the volume of GTV based on CE-CT plus FAPI Â20%, 30%, and 40% showed no significant difference with GTV CT and planning target volume based CE-CT plus FAPI-PET and meets the organ at risk standard. Conclusion:The 68 Ga-FAPI PET/CT methodology showed favourable tumour-to-background contrast in oesophageal cancer and might provide additional information for target volume delineation and help avoid tumour geographic misses.

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Role of [68Ga]Ga-DOTA-FAPI-04 PET/CT in the evaluation of peritoneal carcinomatosis and comparison with [18F]-FDG PET/CT

Zhao

Pang

Luo

et al. 2021

Eur J Nucl Med Mol Imaging

106

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Usefulness of [18F]fluorodeoxyglucose PET/CT for evaluating the PD-L1 status in nasopharyngeal carcinoma

Cited by 27 publications

References 42 publications

CT radiomics and morphological characteristics for predicting PD-L1 expression on tumor cells and tumor infiltrating lymphocytes in gastric cancer

CT radiomics and morphological characteristics for predicting PD-L1 expression on tumor cells and tumor infiltrating lymphocytes in gastric cancer

68Ga-fibroblast activation protein inhibitor PET/CT on gross tumour volume delineation for radiotherapy planning of oesophageal cancer

Role of [68Ga]Ga-DOTA-FAPI-04 PET/CT in the evaluation of peritoneal carcinomatosis and comparison with [18F]-FDG PET/CT

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