Usefulness of C-Reactive Protein to High-Molecular-Weight Adiponectin Ratio to Predict Insulin Resistance and Metabolic Syndrome in Japanese Men

Saisho, Yoshifumi; Hara, Hiroshi; Seino, Y.; Saito, Ikuo; Itoh, Hiroshi

doi:10.5551/jat.4234

Cited by 6 publications

(7 citation statements)

References 43 publications

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“…Several studies have demonstrated that many people with MetS have an elevated hsCRP concentration [5], which may predict their risk for future adverse events [6]. …”

Section: Introductionmentioning

confidence: 99%

Usefulness of combining serum uric acid and high-sensitivity C-reactive protein for risk stratification of patients with metabolic syndrome in community-dwelling women

et al. 2013

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Metabolic syndrome (MetS) is associated with an increased risk of major cardiovascular events. In women, increased uric acid (UA) levels are associated with MetS and its components. High-sensitivity C-reactive protein (hsCRP) levels are also associated with MetS, and hsCRP levels could be modulated by UA. We investigated whether combining UA and hsCRP levels are independently associated with MetS and insulin resistance in Japanese community-dwelling women. From a single community, we recruited 1,097 women (63 ± 12 years) during their annual health examination, and examined the cross-sectional relationship between UA, hsCRP, and MetS and insulin resistance, which was evaluated by homeostasis of minimal assessment of insulin resistance. Of these subjects, 218 women (19.9 %) had MetS. Multiple linear regression analysis was performed to evaluate the contribution of each confounding factor for MetS and insulin resistance, both UA and hsCRP as well as age and alcohol consumption, were independently and significantly associated with MetS and insulin resistance. The adjusted-odds ratios (95 % confidence interval) for MetS across tertiles of UA and hsCRP were 1.00, 1.45 (0.95–2.22), and 2.61 (1.74–3.93), and 1.00, 1.80 (1.18–2.74), and 3.23 (2.15–4.85), respectively. In addition, the combination increased UA, and hsCRP was also a significant and independent determinant for MetS and insulin resistance. In direction associations, we also observed a synergistic effect between these two molecules (F = 2.76, P = 0.027). These results suggested that combined assessment of UA and hsCRP levels provides incremental information for risk stratification of patients with MetS, independent of other confounding factors in community-dwelling women.

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“…Several studies have demonstrated that many people with MetS have an elevated hsCRP concentration [5], which may predict their risk for future adverse events [6]. …”

Section: Introductionmentioning

confidence: 99%

Usefulness of combining serum uric acid and high-sensitivity C-reactive protein for risk stratification of patients with metabolic syndrome in community-dwelling women

et al. 2013

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“…Adiponectin and CRP are independent risk factors of CVD, together serve a synergistic role in metabolic regulation in the general population and T2D subjects [35][36][37] . We found that AA women with high adiponectin and low CRP levels, which translated into a high ratio, had significantly lower FG, IN, HOMA-IR, WC, %BF and BMI relative to those with a low ratio.…”

Section: Comparedmentioning

confidence: 99%

Role of plasma adiponectin /C-reactive protein ratio in obesity and type 2 diabetes among African Americans

Abraham¹,

Attipoe²,

Kazman³

et al. 2017

Afr H. Sci.

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“…High serum hsCRP levels are seen in MetS and studies demonstrated that increased serum hsCRP level is an important inflammatory marker in the risk of cardiovascular disease (26)(27)(28)(29). In the CU pathogenesis, increased serum CRP level was reported and it showed positive correlation with disease activity (5,17,30).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Serum Resistin Levels and Metabolic Syndrome Related Parameters in Chronic Spontaneous Urticaria

Akca¹,

Bulur²,

Saraçoğlu³

et al. 2017

tdd

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Amaç: Kronik spontan ürtiker (KSÜ) hastalarında serum resistin düzeyi ve metabolik sendrom (MetS) ilişkisini değerlendirmek. Yöntemler: Çalışmaya 42 KSÜ hastası ve 42 sağlıklı gönüllü dahil edildi. Boy, kilo, bel çevresi ve kan basıncı ölçümleri her iki grupta da değerlendirildi. Açlık kan şekeri, serum lipid düzeyleri, resistin ve tümör nekroz faktörü-alpha (TNF-α) düzeyleri venöz kan örneklerinde değerlendirildi. MetS tanısı National Cholesterol Education Program Adult Treatment Panell III tanı kriterleri ile belirlendi. Bulgular: KSÜ hastalarının 14'ünde (%33,3) ve kontrol grubunun 5'inde (%11,9) MetS saptandı. İki grup arasında MetS varlığı açısından istatistiksel olarak anlamlı fark bulundu, p=0,037. KSÜ hastalarının serum resistin düzeyleri ortalaması 1928,31±212,85 pg/mL ve kontrol grubunun serum resistin düzeyleri ortalaması 2107,60±156,71 pg/mL olarak saptandı. Her iki grup arasında serum resistin düzeyi açısından istatistiksel anlamlı fark görülmedi. KSÜ hastalarında MetS tanısı olan hastalar ile MetS tanısı olmayan hastalar arasında ürtiker aktivite skoru, hastalık süresi, otolog serum deri testi pozitifliği, serum immünoglobulin E düzeyi, otoimmünite varlığı, serum resistin ve TNF-α düzeyi açısından farklılık görülmedi. Sonuç: Çalışmamızda KSÜ hasta grubunda MetS görülme sıklığında artış olduğu saptanmıştır. Diğer taraftan KSÜ hastaları içinde MetS'yi olan ve olmayan iki grup arasında hastalık ilişkili parametreler ile serum resistin ve TNF-α düzeyi farklılık göstermemiştir. Anahtar kelimeler: Kronik spontan ürtiker, metabolik sendrom, resistin, tümör nekroz faktörü-alfa, ürtiker aktivite skoru, otolog serum deri testi Öz AbstractObjective: To evaluate the relationship between the serum resistin levels and metabolic syndrome (MetS) in chronic spontaneous urticaria (CSU) patients. Methods: In the study 42 CSU patients and 42 healthy volunteers were included. Height, weight, waist circumference, and blood pressure measurements were assesed for both of the groups. Fasting blood sugar, serum lipid levels, resistin and tumor necrosis factor-alpha (TNF-α) levels were evaluated in the venous blood samples. The metabolic syndrome (MetS) diagnosis was determined using the National Cholesterol Education Program Adult Treatment Panel III diagnostic criteria. Results: MetS was found in 14 (33.3%) CSU patients and 5 (11.9%) control subjects. There was a statistically significant difference between the two groups (p=0.037) in terms of MetS presence. It was found that the mean serum resistin levels was 1928.31±212.85 pg/ mL in the CSU patients and 2107.60±156.71 pg/mL in the control group. There was no statistically significant difference between the groups in terms of serum resistin levels. No difference was seen between the patients with and without a diagnosis of MetS regarding the urticaria activity score, duration of the disease, autologous serum skin test positivity, serum immunoglobulin E levels, presence of autoimmunity, serum resistin and TNF-α levels. Conclusion: An increased incidence of MetS in the CSU ...

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Usefulness of C-Reactive Protein to High-Molecular-Weight Adiponectin Ratio to Predict Insulin Resistance and Metabolic Syndrome in Japanese Men

Cited by 6 publications

References 43 publications

Usefulness of combining serum uric acid and high-sensitivity C-reactive protein for risk stratification of patients with metabolic syndrome in community-dwelling women

Usefulness of combining serum uric acid and high-sensitivity C-reactive protein for risk stratification of patients with metabolic syndrome in community-dwelling women

Role of plasma adiponectin /C-reactive protein ratio in obesity and type 2 diabetes among African Americans

Evaluation of Serum Resistin Levels and Metabolic Syndrome Related Parameters in Chronic Spontaneous Urticaria

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