Usefulness of cyclodextrins for detection in molecular fluorescence. Application to xenobiotics and drugs

Prognon, Patrice; Kasselouri, Athéna; Desroches, Marie-Catherine; Mahuzier, G.

doi:10.1051/analusis:2000280664

Cited by 13 publications

(7 citation statements)

References 29 publications

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“…A similar influence was found for a-CD (data not shown). The increase of the fluorescence quantum yield of tryptamine in the presence of b-CD was attributed to the formation of 1:1 inclusion complexes [22] and is explained by the restriction of intermolecular rotation in the rigid environment of the cavity and/or the exclusion of solvent relaxation [18].…”

Section: Fluorescencementioning

confidence: 99%

“…This effect is based on an enhancement of the fluorescence quantum yield due to a decrease in the rotation motion of the entrapped molecule and/or decrease in solvent relaxation [18]. In our work, we studied the influence of pH, the presence or absence of SDS micelles, and the influence of the a-CD concentration in the separation electrolyte on the selectivity of the separation and on the sensitivity of the detection.…”

Section: Introductionmentioning

confidence: 99%

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Determination of tryptamine derivatives in illicit synthetic drugs by capillary electrophoresis and ultraviolet laser-induced fluorescence detection

et al. 2005

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A method based on separation by capillary electrophoresis combined with UV-laser-induced fluorescence detection (Lambdaex = 266 nm) was developed for the determination of nine tryptamine derivatives of forensic interest and potential matrix constituents. The composition of the separation electrolyte was optimized with respect to the resolution of solutes of interest and to the sensitivity of fluorescence detection. Native alpha-cyclodextrin was employed as a complex forming modifier of the electrophoretic separation and fluorescence-enhancing agent. With the help of a stacking procedure, limits of detection of 0.1-6 microg/L for all analytes were obtained. The repeatability for the peak area (at a concentration of the analyte about 100 times the LOD) was less than 2.3% RSD. A second HPLC method was developed, and its analytical parameters were evaluated for an estimation of the accuracy of the CE-LIF method and for method comparison. The results of the determination of tryptamine derivatives in the samples of forensic interest obtained with the two independent methods are in good agreement.

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Section: Fluorescencementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determination of tryptamine derivatives in illicit synthetic drugs by capillary electrophoresis and ultraviolet laser-induced fluorescence detection

et al. 2005

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“…The formation of these host-guest complexes can dramatically improve the solubility and stability of guest molecules, as well as modify their chemical properties. Among CD applications, their use as drug carriers is the best documented in the literature [7][8][9], followed by their use as additives to foods and flavors [10][11][12], to cosmetics [13][14][15], in packaging [16] and textile industry [17], in analytical chemistry [18,19] and bioremediation [20,21].…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrins as Food Additives and in Food Processing

Cravotto¹,

Binello²,

Baranelli³

et al. 2006

CNF

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This review deals with the applications of cyclodextrins (CDs) to food manufacture, focusing on the technical advantages of their use in food processing and as food additives. Their beneficial effects essentially derive from the ability to form stable inclusion complexes with sensitive lipophilic nutrients and constituents of flavor and taste. Toxicological data are examined and an assessment of CDs from the standpoint of safety for human consumption is made. Regulations are covered, showing a general trend towards a wider acceptance of CDs as food additives. The growing health consciousness of consumers and expanding market for functional foods and nutraceutical products are opening up to CDs a promising future in food industry.

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“…Detection is useful for the high sensitivity detection of fluorescent analytes, either native fluorescent or dye‐labeled compounds. In addition, in chiral EKC analysis the addition of CD into the BGE could significantly enhance the fluorescence quantum yield, mainly by decreasing rotation motion of the entrapped molecule 36. LIF systems have mainly been used in chiral CE for the sensitive detection of derivatized AA enantiomers up to concentrations about 10 −10 M 8, 9.…”

Section: Approaches For Improving Detection Sensitivitymentioning

confidence: 99%

Recent approaches for enhancing sensitivity in enantioseparations by CE

et al. 2009

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This article reviews the latest methodological and instrumental improvements for enhancing sensitivity in chiral analysis by CE. The review covers literature from March 2007 until May 2009, that is, the works published after the appearance of the latest review article on the same topic by Sánchez-Hernández et al. [Electrophoresis 2008, 29, 237-251]. Off-line and on-line sample treatment techniques, on-line sample preconcentration strategies based on electrophoretic and chromatographic principles, and alternative detection systems to the widely employed UV/Vis detection in CE are the most relevant approaches discussed for improving sensitivity. Microchip technologies are also included since they can open up great possibilities to achieve sensitive and fast enantiomeric separations.

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Usefulness of cyclodextrins for detection in molecular fluorescence. Application to xenobiotics and drugs

Cited by 13 publications

References 29 publications

Determination of tryptamine derivatives in illicit synthetic drugs by capillary electrophoresis and ultraviolet laser-induced fluorescence detection

Determination of tryptamine derivatives in illicit synthetic drugs by capillary electrophoresis and ultraviolet laser-induced fluorescence detection

Cyclodextrins as Food Additives and in Food Processing

Recent approaches for enhancing sensitivity in enantioseparations by CE

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