Usefulness of Mean Platelet Volume to Predict Significant Coronary Artery Disease in Patients With Non–ST-Elevation Acute Coronary Syndromes

Taşkesen, Tuncay; Sekhon, Harsimran; Wroblewski, Igor; Goldfarb, Mikhail; Ahmad, Muhammad B.; Nguyen, Quan Huu; Fughhi, Ibtihaj; Gidron, Adi; Dadkhah, Shahriar

doi:10.1016/j.amjcard.2016.09.042

Cited by 24 publications

(26 citation statements)

References 28 publications

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“…Similarly, some authors have argued that there is a high correlation between MPV and CVDs . Besides, this biomarker could be an early predictive factor for cardiac diseases and could give information for prognosis of the pathology . Also, Cetin et al found a relationship between MPV and thrombolysis failure in patients with ST‐segment elevation MI .…”

Section: Discussionmentioning

confidence: 96%

“…11,15,22 Besides, this biomarker could be an early predictive factor for cardiac diseases and could give information for prognosis of the pathology. 16,23,24 Also, Cetin et al found a relationship between MPV and thrombolysis failure in patients with ST-segment elevation MI. 25 In relation to these studies, we found that O blood group subjects have considerably decreased MPV levels than do B…”

Section: Discussionmentioning

confidence: 99%

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The relationship between platelet indices and ABO blood groups in healthy adults

Çelik

Düzenli

Aslan

et al. 2018

Clinical Laboratory Analysis

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Background ABO blood groups have been suggested to have a high correlation with cardiovascular diseases (CVDs). It has also been postulated that platelet indices, including mean platelet volume (MPV) and platelet distribution width (PDW), are very important in the development and progression of CVDs. However, despite these common associations with CVDs, as far as we know, there are no studies investigating platelet indices in ABO blood groups. Thus, the aim of this study was to investigate whether platelet indices are associated with ABO blood groups. Methods The study included 301 healthy volunteers (99 women and 202 men; mean age: 32.59 ± 7.52 years) whose blood groups were determined by the gel column method using agglutination techniques. Platelet indices were studied by an automated blood counter. Results No considerable differences in age, gender, or Rh factors were observed among ABO blood groups. MPV was detected to be considerably lower in O and A blood group subjects than in AB and B blood group subjects. Similarly, PDW was significantly lower in O and A blood group subjects than in B blood group subjects. Additionally, MPV in the O blood group subjects was significantly lower than in the non‐O blood group subjects. Conclusions Because MPV and PDW are used as markers of CVDs, individuals with O and A blood groups in this study may be considered to have a lower risk of CVDs than AB and B blood group subjects. However, prospective cohort studies involving a greater number of volunteers are needed to elucidate these relationships.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

The relationship between platelet indices and ABO blood groups in healthy adults

Çelik

Düzenli

Aslan

et al. 2018

Clinical Laboratory Analysis

View full text Add to dashboard Cite

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“…Previous studies revealed that low HDL was caused by increased proliferation of megakaryocyte progenitors and increased production of immature platelets in the bone marrow, thus the relationship between high MPV and low HDL could reflect the presence of an atherogenic and significant CHD. 1 In research by Gunaydin et al (2016), it was found that HDL and family history had a significant implication for the incidence of high Syntax scores. 5 This is consistent with our study with significant association in family history and in HDL level for higher Syntax score ( Table 3).…”

Section: Resultsmentioning

confidence: 97%

“…In NSTEMI, high risk stratification is recommended for invasive strategies. 1,2 Despite risk stratification, 14-20% of patients who have coronary angiography have normal or non-significant coronary heart disease (CHD). Investigation of new markers combined with cardiac imaging and stress tests may be better for predicting patients with NSTEMI with significant atherosclerosis and may reduce invasive strategies that are not needed.…”

Section: Introductionmentioning

confidence: 99%

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Mean Platelet Volume as a Predictor of Atherosclerotic Severity in Non ST Elevation Acute Myocardial Infarction

Astuti

Setianto

Taufiq

2019

Acta Cardiol Indones

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Background: Acute myocardial infarction (AMI) is the leading cause of death in the world. AMI is classified into ST-elevation myocardial infarction (STEMI) and Non-ST elevation myocardial infarction (NSTEMI). Diagnosis and prediction of severity of atherosclerotic in NSTEMI is a challenge. Despite the risk stratification, 14-20% of patients that undergo coronary angiography have normal or non significant coronary artery disease. The role of platelet and the extent of atherotrombosis in patients with NSTEMI are interesting field of research. Mean platelet volume (MPV) reflects platelet size and reactivity. It can be used as a diagnostic marker and may have predictive value. This study aims to prove the role of MPV as a predictor of the degree of atherosclerotic based on Syntax score in patients with NSTEMI undergoing coronary angiography. Methods: This is a cross sectional study enrolled 86 subjects with NSTEMI. Blood samples were taken at the time of admission to the hospital. An MPV was measured by automated machine. Subsequent coronary angiography was performed using standardized method. Syntax score was determined to reflect the atherosclerotic severity. Statistical analysis was used to assess whether an MPV as a predictor of atherosclerotic severity based on Syntax score. Results: The chi-square analysis showed that high MPV could not be used as a predictor of the atherosclerotic severity based on Syntax score in NSTEMI patients (p value =0.5, prevalence ratio 1.15 (95% CI: 0.755-1.753). From multivariate analysis, only smoking factor had an independent relationship with Syntax score (p value =0.047; Odds ratio 2.531(95% CI: 1.012-6.328). Conclusions: High MPV cannot be used as a predictor of atherosclerotic severity based on Syntax score in NSTEMI patients. INTISARILatar Belakang: Infark miokard akut (IMA) merupakan penyebab kematian di dunia. IMA diklasifikasikan menjadi ST elevasi (IMA-EST) dan Non ST elevasi (IMA-NEST). Diagnosis dan prediksi beratnya aterosklerosis pada IMA-NEST dan angina pectoris tidak stabil, merupakan tantangan. Meskipun sudah dilakukan stratifikasi risiko, 14-20% pasien yang dilakukan angiografi koroner didapatkan normal atau non signifikan. Pengenalan peran platelet dan luasnya aterotrombosis pada pasien IMA-NEST menarik untuk dilakukan penelitian. Mean Platelet Volume (MPV) mencerminkan ukuran platelet dan reaktivitas, bisa dipakai sebagai diagnostik dan mungkin mempunyai nilai prediktif. Penelitian ini bertujuan untuk membuktikan peranan MPV yang meningkat bisa sebagai prediktor terhadap derajat beratnya aterosklerosis berdasarkan skor Syntax pada pasien IMA-NEST yang dilakukan angiografi koroner. Metode Penelitian: Penelitian ini menggunakan desain penelitian potong lintang sebanyak 86 pasien yang memenuhi kriteria inklusi. Sampel darah diambil pada saat pasien masuk ke rumah sakit. MPV diperiksa dengan mesin otomatis. Angiografi koroner dilakukan dengan metode standar. Skor Syntax dinilai untuk menentukan keparahan lesi aterosklerosis koroner. Analisa statistik digunakan untuk ...

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Letter by Garcia A, et al. regarding article “The clinical evaluation of the CADence device in the acoustic detection of coronary artery disease”

García-Escobar

Grande

Cabestrero

2018

Int J Cardiovasc Imaging

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Usefulness of Mean Platelet Volume to Predict Significant Coronary Artery Disease in Patients With Non–ST-Elevation Acute Coronary Syndromes

Cited by 24 publications

References 28 publications

The relationship between platelet indices and ABO blood groups in healthy adults

The relationship between platelet indices and ABO blood groups in healthy adults

Mean Platelet Volume as a Predictor of Atherosclerotic Severity in Non ST Elevation Acute Myocardial Infarction

Letter by Garcia A, et al. regarding article “The clinical evaluation of the CADence device in the acoustic detection of coronary artery disease”

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