Usefulness of the blood lymphocyte count in predicting recurrent instability and death in patients with unstable angina pectoris

Zouridakis, Emmanouil; García-Moll, Xavier; Kaski, Juan Carlos

doi:10.1016/s0002-9149(00)00963-2

Cited by 133 publications

(118 citation statements)

References 14 publications

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“…26 In a systematic review, including 21 studies and more than 34,000 patients, a signif icant relationship between clinical outcomes and neutrophils, measured as abso- 27 More specifically, several investigators showed that neutrophils measured within 24 hours after symptom onset were long-term predictors of death after AMI and ACS. [27][28][29] Conversely, Zouridakis and associates 30 found no correlation between neutrophils and clinical outcomes (death after hospital discharge meshed with other clinical outcomes). In the current study, an increased neutrophil count (especially in Q4) was associated with higher long-term mortality rates in the univariate analysis, but not in the multivariate analysis.…”

Section: Discussionmentioning

confidence: 96%

White Blood Cell Subtypes Are Associated with a Greater Long-Term Risk of Death after Acute Myocardial Infarction

Shiyovich¹,

Gilutz²,

Plakht³

2017

Texas Heart Institute Journal

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We evaluated the association between white blood cell counts and long-term mortality rates in 2,129 patients (mean age, 65.3 ± 13.5 yr; 69% men) L ong-term risk stratification after acute myocardial infarction (AMI) is of great importance, because the benefits of costly interventions and medical treatments are greatest in patients who are at higher risk.1 Evidence indicates that inflammation plays a crucial role in the atherosclerotic process, from its initiation, progression, plaque destabilization, triggering of an acute coronary event, and infarction size, to recuperation after AMI has occurred.2-4 Moreover, it has been postulated that the greater the inflammatory response during the acute phase of AMI, the greater the proinflammatory activity during chronic (stable) phases of the disease.5 Several inflammatory biomarkers (such as C-reactive protein and lipoprotein-associated phospholipase A 2 ) have been identified as important for risk stratification after AMI. 6,7 The circulating white blood cell (WBC) count and differential counts are simple, inexpensive-to-test, and readily available inflammatory markers 8 that have been associated with event rates in patients with coronary heart disease. 9,10 In addition, investigators have related high WBC count to death after AMI.11,12 Moreover, Taglieri and colleagues 13 have reported that WBC count is an independent predictor of 3-year death in patients with non-ST-segment-elevation acute coronary syndrome (ACS), yet this predictor did not add prognostic information beyond the Global Registry of Acute Coronary Events (Grace) score. However, prognosis was usually evaluated for a relatively short time in most studies. Investigators have often included WBC count without subtypes, included only a few subtypes, or applied incomparable methodologies. The independent prognostic value of WBC count and its subtypes, adjusted to other risk factors, has been debatable, and its evaluation as part of post-AMI prognostication has not been performed often.We investigated the association of total and differential WBC counts in regard to long-term mortality rates (at 1-, 5-, and 10-yr follow-up) and evaluated the latter values as incremental predictors with use of a validated prognostic tool: the Soroka Acute Myocardial Infarction (SAMI) score, which integrates cardiovascular risk factors and affective comorbidities into an index score.

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Section: Discussionmentioning

confidence: 96%

White Blood Cell Subtypes Are Associated with a Greater Long-Term Risk of Death after Acute Myocardial Infarction

Shiyovich¹,

Gilutz²,

Plakht³

2017

Texas Heart Institute Journal

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“…(11) Although the pathophysiological mechanism of this condition is not fully understood, lymphocyte count is thought to reflect the early response of myocardial ischemia to physiological stress and systemic immunodeficiency.…”

Section: Discussionmentioning

confidence: 99%

Correlations between hematological indicators and other known markers in acute coronary syndromes

Ertürk¹,

Çağlar²,

Bıyık³

2017

ejcm

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Introduction:Recently, many hematologic markers have identified as prognostic and diagnostic indicators in different acute coronary syndrome (ACS) patients. In particular, neutrophil / lymphocyte ratio (NLR) and platelet / lymphocyte ratio (PLR) are recognized as markers in the diagnosis and prognosis of ACS. In this study, our aim was to investigate the correlation between the diagnostic yield of PLR and NLR values and other markers such as troponin in all ACS patients. Material and methods:319 patients admitted to our hospital with ACS and 283 control patients were included in the study. Leukocyte, neutrophil, platelet, lymphocyte counts, PLR, NLR and high sensitive troponin I (HsTnI) measurements were taken.Results: Leukocyte, neutrophil and platelet counts were significantly higher in the ACS group than the controls (p <0.001). Lymphocyte count was significantly lower in the ACS group than the controls (p <0.001). NLR and PLR were found to be significantly higher in the ACS group than the controls (4.0 ± 3.3 vs 2.1 ± 1.4 and 126.3 ± 68.9 vs 106.9 ± 49.4, p <0.001, respectively). NLR was showed significant correlation with HsTnI, PLR, angina time, presence of ST elevation and T wave negativity (p <0.05), and PLR revealed significant correlation with NLR, HsTnI, ST elevation and T wave negativity (p <0.05). Conclusion:Hematologic markers were found to be significantly higher in the ACS group than the controls. The difference also continued in subgroup analyzes. NLR and PLR correlated with many other ACS indicators.Key words: Platelet lymphocyte ratio, neutrophil lymphocyte ratio, acute coronary syndrome, troponin. Abstract

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“…Lymphocyte concentrations were found to be lower in patients with ACS. The reduction in lymphocyte count might be related to physiological stress that leads to increased cortisol production and increased apoptosis of lymphocyte triggered by increased inflammation 15,16 . In our study neutrophil count was increased and lymphocyte count was decreased significantly in the patients with coronary thrombus when compared to the patients without coronary thrombus.…”

Section: Discussionmentioning

confidence: 99%

Eosinophil count is related with coronary thrombus in non ST-elevated acute coronary syndrome

Tenekecioğlu¹,

Yılmaz²,

Bekler³

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. White blood cells are reported as important not only in plaque vulnerability but also in thrombus formation and thrombus growth in acute coronary syndromes. Eosinophils contain granules that promote thrombus formation and thrombus growth in some heart diseases. In this study we aimed to investigate the relation of eosinophil count with coronary thrombus formation in patients with non ST-elevated acute coronary syndrome (NST-ACS). Method. A total of 251 consecutive patients were hospitalized in our hospital with a diagnosis of NST-ACS. Venous blood is collected for measurement of hematologic indices in all patients undergoing the coronary angiography. Coronary angiographies were performed in our clinic using the standard Judkins technique and angiographic assessment of the presence of thrombus was made. Results. During coronary angiography, coronary thrombus was not detected in 82 patients (Group 1). In the coronary angiography of 169 patients, coronary thrombus was detected at various grades (Group 2). While the neutrophil count (6.84±1.94 vs. 5.53±1.37; P<0.001) and eosinophil count (0.257±0.125 vs. 0.163±0.114; P<0.005) was significnatly increased in the group with coronary thrombus, the lymphocyte count (1.87±0.66 vs. 2.00±0.70; P<0.001) was significantly decreased in the group with coronary thrombus as compared to the patient group without coronary thrombus. In the correlation analyzes; presence of coronary thrombus is correlated with total cholesterol, LDL-C, total CK, CK-MB, troponin, total number of diseased coronary, platelet count, neutrophil count, lymphocyte count and eosinophil count. On multivariate linear regression analysis, total leukocyte count, neutrophil count, lymphocyte count, eosinophil count, troponin and total cholesterol was found to be independent predictor of coronary thrombus in patients with NST-ACS. Conclusion. Beside the increased neutrophil count, increased eosinophil count in CBC should alert the clinician about coronary thrombus development in patients with NST-ACS in order to make early medical interventions at acute phase of the disease.

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Usefulness of the blood lymphocyte count in predicting recurrent instability and death in patients with unstable angina pectoris

Cited by 133 publications

References 14 publications

White Blood Cell Subtypes Are Associated with a Greater Long-Term Risk of Death after Acute Myocardial Infarction

White Blood Cell Subtypes Are Associated with a Greater Long-Term Risk of Death after Acute Myocardial Infarction

Correlations between hematological indicators and other known markers in acute coronary syndromes

Eosinophil count is related with coronary thrombus in non ST-elevated acute coronary syndrome

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