Ecosystem services (ESs) are an essential link between ecosystems and human well-being, and trade-offs/synergies happen in ESs at different temporal and spatial scales. It is crucial to explore patterns of trade-offs/synergies among ESs, and their nonlinear relationships with changes in ESs. The primary objective of this study was to evaluate five ESs in 2000 and 2018: namely, water yield, food production, carbon sequestration, soil conservation, and habitat quality in mountainous regions of Southwest China. The mean values of the five ESs increased by 365.8 m3/ha, 13.92 t/hm2, 497.09 TgC/yr2, 138.48 t/km2, and 0.002, respectively. Using spatial statistics and analysis, an ES trade-off synergy model (ESTD) was constructed for the five ESs change values. Overall, soil conservation has a trade-off with all five ESs, except habitat quality; this trade-off is increasing slightly. Water yield is in synergy with all ESs except soil conservation, with decreasing synergy; habitat quality is in synergy with all ESs except food production, with increasing synergy. Finally, the nonlinear relationship between the value of the change in the ES and ESTD was analyzed using a generalized additive model. Changes in water yield showed the greatest impact on ESTD except for food production, wherein changes in all three ESs had minimal impacts on ESTD. Food production dominates its trade-offs/synergies relationship with soil conservation; carbon sequestration is the dominant player in its trade-offs/synergies relationship with soil conservation. Habitat quality has a secondary position of influence, except in the trade-offs/synergies involving food production. By exploring the drivers of trade-offs/synergies among ESs, this study can provide guidance for the effective implementation of policies related to ecological protection and restoration.