Using HAADF-STEM for atomic-scale evaluation of incorporation of antibacterial Ag atoms in a β-tricalcium phosphate structure

Gokcekaya, Ozkan; Ueda, Kyosuke; Narushima, Takayuki; Nakano, Takayoshi

doi:10.1039/d0nr04208k

Cited by 9 publications

(6 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The noticeable diffraction of the generated pattern in terms of d -spacing and crystal planes were matched with the standard ICDD database (card no#: 04-006-9376). No other phase was found in the pattern except rhombohedral β-TCP of R 3 c space group 24 and a similar type of β-TCP has been reported in the literature. 20,25 Rietveld refinement was done to quantify the phase percentage of β-TCP and hydroxyapatite (HA, card no#:01-074-0566) by using Rigaku Smart Lab Studio II software.…”

Section: Resultssupporting

confidence: 81%

“…The noticeable diffraction of the generated pattern in terms of d-spacing and crystal planes were matched with the standard ICDD database (card no#: 04-006-9376). No other phase was found in the pattern except rhombohedral b-TCP of R3c space group 24 and a similar type of b-TCP has been reported in the literature. 20,25 ) very small peaks (relative intensity ∼1%) out of total 46 peaks were not coincided with the mentioned standard.…”

Section: Characterizationsupporting

confidence: 81%

See 1 more Smart Citation

β-tricalcium phosphate synthesized in organic medium for controlled release drug delivery application in bio-scaffolds

Sahadat Hossain,

Shaikh,

Uddin

et al. 2023

RSC Adv.

View full text Add to dashboard Cite

show abstract

Section: Resultssupporting

confidence: 81%

“…The noticeable diffraction of the generated pattern in terms of d-spacing and crystal planes were matched with the standard ICDD database (card no#: 04-006-9376). No other phase was found in the pattern except rhombohedral b-TCP of R3c space group 24 and a similar type of b-TCP has been reported in the literature. 20,25 ) very small peaks (relative intensity ∼1%) out of total 46 peaks were not coincided with the mentioned standard.…”

Section: Characterizationsupporting

confidence: 81%

β-tricalcium phosphate synthesized in organic medium for controlled release drug delivery application in bio-scaffolds

Sahadat Hossain,

Shaikh,

Uddin

et al. 2023

RSC Adv.

View full text Add to dashboard Cite

show abstract

“…This may result in a decrease in the lattice parameter c and stabilization of the βTCP structure. The existence of silver in Ca(4) positions in Ag-doped βTCP was recently confirmed via the high-angle annular dark-field scanning transmission electron microcopy observations [ 34 ].…”

Section: Resultsmentioning

confidence: 95%

Silver Decorated βTCP-Poly(3hydroxybutyrate) Scaffolds for Bone Tissue Engineering

et al. 2021

View full text Add to dashboard Cite

Implantations in orthopedics are associated with a high risk of bacterial infections in the surgery area. Therefore, biomaterials containing antibacterial agents, such as antibiotics, bactericidal ions or nanoparticles have been intensively investigated. In this work, silver decorated β tricalcium phosphate (βTCP)-based porous scaffolds were obtained and coated with a biopolymer—poly(3-hydroxybutyrate)-P(3HB). To the best of our knowledge, studies using silver-doped βTCP and P(3HB), as a component in ceramic-polymer scaffolds for bone tissue regeneration, have not yet been reported. Obtained materials were investigated by high-temperature X-ray diffraction, X-ray fluorescence, scanning electron microscopy with energy dispersive spectroscopy, hydrostatic weighing, compression tests and ultrahigh-pressure liquid chromatography with mass spectrometry (UHPLC-MS) measurements. The influence of sintering temperature (1150, 1200 °C) on the scaffolds’ physicochemical properties (phase and chemical composition, microstructure, porosity, compressive strength) was evaluated. Materials covered with P(3HB) possessed higher compressive strength (3.8 ± 0.6 MPa) and surgical maneuverability, sufficient to withstand the implantation procedures. Furthermore, during the hydrolytic degradation of the composite material not only pure (R)-3-hydroxybutyric acid but also its oligomers were released which may nourish surrounding tissues. Thus, obtained scaffolds were found to be promising bone substitutes for use in non-load bearing applications

show abstract

“…Incorporating silver into 𝛽-TCP ceramics has been investigated in several studies. The research by Gokcekaya et al [129][130][131] showed that Ag incorporation into 𝛽-TCP (Ag-𝛽-TCP) can lower the lattice parameters of 𝛽-TCP and suppress the phase-change from 𝛽-TCP to 𝛼-TCP, giving better sintering density and good mechanical strength of 𝛽-TCP. Additionally, it is found that Ag-TCP is characterized by excellent properties such as high silver solubility, good antibacterial properties, and high bioresorbability.…”

Section: Solid-state Reactionmentioning

confidence: 99%

Silver‐Containing Biomaterials for Biomedical Hard Tissue Implants

Shao

Zhang

Gong

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

Bacterial infection caused by biomaterials is a very serious problem in the clinical treatment of implants. The emergence of antibiotic resistance has prompted other antibacterial agents to replace traditional antibiotics. Silver is rapidly developing as an antibacterial candidate material to inhibit bone infections due to its significant advantages such as high antibacterial timeliness, high antibacterial efficiency, and less susceptibility to bacterial resistance. However, silver has strong cytotoxicity, which can cause inflammatory reactions and oxidative stress, thereby destroying tissue regeneration, making the application of silver‐containing biomaterials extremely challenging. In this paper, the application of silver in biomaterials is reviewed, focusing on the following three issues: 1) how to ensure the excellent antibacterial properties of silver, and not easy to cause bacterial resistance; 2) how to choose the appropriate method to combine silver with biomaterials; 3) how to make silver‐containing biomaterials in hard tissue implants have further research. Following a brief introduction, the discussion focuses on the application of silver‐containing biomaterials, with an emphasis on the effects of silver on the physicochemical properties, structural properties, and biological properties of biomaterials. Finally, the review concludes with the authors’ perspectives on the challenges and future directions of silver in commercialization and in‐depth research.

show abstract

Using HAADF-STEM for atomic-scale evaluation of incorporation of antibacterial Ag atoms in a β-tricalcium phosphate structure

Abstract: Structural evaluation of ionic additions in calcium phosphates that enhance their performance is a long-lasting area of research in the field of biomedical materials. Ionic incorporation in β-tricalcium phosphate (β-TCP)...

Cited by 9 publications

References 52 publications

β-tricalcium phosphate synthesized in organic medium for controlled release drug delivery application in bio-scaffolds

β-tricalcium phosphate synthesized in organic medium for controlled release drug delivery application in bio-scaffolds

Silver Decorated βTCP-Poly(3hydroxybutyrate) Scaffolds for Bone Tissue Engineering

Silver‐Containing Biomaterials for Biomedical Hard Tissue Implants

Contact Info

Product

Resources

About