Using matrix metalloprotease-9 (MMP-9) to trigger supramolecular hydrogelation

Yang, Zhimou; Ma, Manlung; Xu, Bing

doi:10.1039/b908206a

Cited by 49 publications

(66 citation statements)

References 35 publications

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“…[16] They can self-assemble into various helical nanostructures. Compounds l,l-and d,d-8Val11PyClO 4 can form gels in water, cyclohexanone, ethanol, 1-propanol, and acetonitrile at 25 8C, and can self-assemble into left-and righthanded twisted nanoribbons, respectively (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Preparation of Single‐Handed Helical Carbon/Silica and Carbonaceous Nanotubes by Using 4,4′‐Biphenylene‐Bridged Polybissilsesquioxane

Zhang

et al. 2013

Chemistry An Asian Journal

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Single-handed, helical, 4,4'-biphenylene-bridged polybissilsesquioxane nanotubes were prepared by using the self-assemblies of a pair of chiral low-molecular-weight gelators as templates. Single-handed, helical, carbon/silica nanotubes were obtained after carbonization of the self-assemblies, and single-handed helical carbonaceous nanotubes were then obtained by removal of silica with aqueous HF. Samples were characterized by using field-emission SEM, TEM, X-ray diffraction, thermogravimetric analysis, Raman spectroscopy, and circular dichroism. The polysilsesquioxane and carbonaceous structures exhibited optical activity. The walls of the carbon/silica and carbonaceous nanotubes were predominantly amorphous carbon. The surface area of the left-handed, helical, carbonaceous nanotubes was 1439 m(2) g(-1), and such materials have potential applications as catalyst supports, chirality sensors, supercapacitor electrodes, and adsorbents.

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Section: Resultsmentioning

confidence: 99%

Preparation of Single‐Handed Helical Carbon/Silica and Carbonaceous Nanotubes by Using 4,4′‐Biphenylene‐Bridged Polybissilsesquioxane

Zhang

et al. 2013

Chemistry An Asian Journal

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“…[26][27][28][29] Although chemical or physical perturbations (e.g., adjusting pH, temperature, ionic strength, and ultrasonic agitation) are the usually used methods to achieve that balance, [2,[30][31][32][33][34][35][36][37][38] enzyme-responsive self-assembly and gelation of the hydrogelators is advantageous for biomedical applications due to the highly efficient catalytic ability of enzymes in mild conditions and the biocompatibility associated with the enzymes. [17,20,39,40] Based on the successful demonstrations of enzymatic formation and stage regulation of supramolcular hydrogels, [17,2,41,42] we report here the regulation of supramolecular hydrogelations by a pair of enzymes and its application in controlled drug release.…”

Section: Introductionmentioning

confidence: 99%

Orthogonal Enzymatic Reactions to Control Supramolecular Hydrogelations

Chen

Ren

et al. 2011

Chin. J. Chem.

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Enzyme-responsive hydrogels have great potential in applications of controlled drug release, tissue engineering, etc. In this study, we reported on a supramolecular hydrogel that showed responses to two enzymes, phosphatase which was used to form the hydrogels and esterase which could trigger gel-sol phase transitions. The gelation process and visco-elasticity property of the resulting gel, morphology of the nanostructures in hydrogel, and peptide conformation in the self-assembled nanostructure were characterized by rheology, transmission electron microscope (TEM), and circular dichroism (CD), respectively. Potential application of the enzyme-responsive hydrogel in drug release was also demonstrated in this study. Though only one potential application of drug release was proved in this study, the responsive hydrogel system in this study might have potentials for the applications in fields of cell culture, controlled-drug release, etc.

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“…7,13,14,15 In this case, we are talking about the socalled injectable hydrogels, the formulations of which are in the sol state under the preparation conditions, enabling "in situ" gelling after injection in the body. The appearance of the sol-gel transition can be triggered by various stimuli including salt, 16,17,18, temperature, 19,20,21,22 , enzymes 23,24,25,26 and pH. 7,27,28,29,30 Alternatively to conventional stimuli responsive systems, a novel class of amphiphiles constructed on the basis of dynamic covalent bonds (DCB) has emerged.…”

Section: Introductionmentioning

confidence: 99%

Injectable Hydrogel: Amplifying the pH Sensitivity of a Triblock Copolypeptide by Conjugating the N-Termini via Dynamic Covalent Bonding

Popescu¹,

Liontos

Avgeropoulos

et al. 2016

ACS Appl. Mater. Interfaces

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We explore the self-assembly behavior of aqueous solutions of an amphiphilic, pH-sensitive poly(l-alanine)-b-poly(l-glutamic acid)-b-poly(l-alanine), (A5E11A5) triblock copolypeptide, end-capped by benzaldehyde through Schiff base reaction. At elevated concentrations and under physiological pH (7.4) and ionic strength (0.15M), the bare copolypeptide aqueous solutions underwent a sol-gel transition after heating and slow cooling thermal treatment, forming opaque stiff gels due to a hierarchical self-assembly that led to the formation of β-sheet-based twisted super fibers (Popescu et al. Soft Matter 2015, 11, 331-342). The conjugation of the N-termini with benzaldehyde (Bz) through a Schiff base reaction amplifies the copolypeptide pH-sensitivity within a narrow pH window relevant for in vivo applications. Specifically, the dynamic character of the imine bond allowed coupling/decoupling of the Bz upon switching pH. The presence of Bz conjugates to the N-termini of the copolypeptide resulted in enhanced packing of the elementary superfibers into thick and short piles, which inhibited the ability of the system for gelation. However, partial cleavage of Bz upon lowering pH to 6.5 prompted recovery of the hydrogel. The sol-gel transition triggered by pH was reversible, due to the coupling/decoupling of the benzoic-imine dynamic covalent bonding, endowing thus the gelling system with injectability. Undesirably, the gelation temperature window was significantly reduced, which however can be regulated at physiological temperatures by using a suitable mixture of the bare and the Bz-conjugated coplypeptide. This triblock copolypeptide gelator was investigated as a scaffold for the encapsulation of polymersome nanocarriers, loaded with a hydrophilic model drug, calcein. The polymersome/polypeptide complex system showed prolonged probe release in pH 6.5, which is relevant to extracellular tumor environment, rendering the system potentially useful for sustained delivery of anticancer drugs locally in the tumor.

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Using matrix metalloprotease-9 (MMP-9) to trigger supramolecular hydrogelation

Abstract: Here we report the first example of using MMP-9 to catalyze the formation and self-assembly of a supramolecular hydrogelator and subsequent hydrogelation.Scheme 1 Illustration of the hydrogelation process catalyzed by MMP-9.

Cited by 49 publications

References 35 publications

Preparation of Single‐Handed Helical Carbon/Silica and Carbonaceous Nanotubes by Using 4,4′‐Biphenylene‐Bridged Polybissilsesquioxane

Preparation of Single‐Handed Helical Carbon/Silica and Carbonaceous Nanotubes by Using 4,4′‐Biphenylene‐Bridged Polybissilsesquioxane

Orthogonal Enzymatic Reactions to Control Supramolecular Hydrogelations

Injectable Hydrogel: Amplifying the pH Sensitivity of a Triblock Copolypeptide by Conjugating the N-Termini via Dynamic Covalent Bonding

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