Uterine lipid metabolism—a review of the literature

Beall, James R.

doi:10.1016/0305-0491(72)90070-3

Cited by 12 publications

(11 citation statements)

References 85 publications

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“…In women, there is evidence of lysosome-mediated release of phospholipases into the amniotic fluid during parturition (Gustavii, 1972;Liggins, Foster, Grieves & Schwatz, 1977), suggesting that phospholipids represent a source of arachidonic acid for PG synthesis. Triglyceride-rich lipid droplets, which accumulate in the uterus during dioestrus and pregnancy in animals of several species, and which are depleted at oestrus (Beali, 1972), have also been suggested as an arachidonic acid source (Brinsfield & Hawk, 1973;Thorburn & Challis, 1979). Our study showed that phospholipids were the major source (93%) of arachidonic acid within the uterus, with depletion of the amount of arachidonic acid bound to phosphatidylcholine occurring on Day 15 of the oestrous cycle (Tables 5 and 6).…”

Section: Methodssupporting

confidence: 53%

“…The uterus is active in the synthesis of fatty acids and their incorporation into lipids in mice (Emmelot & Bosch, 1954), rat, rabbits and man (Beali, 1972) and oestrogen has been reported to increase these processes. The high concentration of arachidonic acid in the phospholipids of the guineapig uterus suggests either that the uterus is capable of specific uptake of arachidonic acid, or, more probably, that enzymes capable of synthesizing arachidonic acid are present in the uterus.…”

Section: Methodsmentioning

confidence: 99%

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Distribution of arachidonic acid and other fatty acids in the lipids of guinea-pig uterus and plasma in relation to uterine prostaglandin synthesis

Ha¹,

Nl²

1981

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Summary. Prostaglandin precursor fatty acids, predominantly arachidonic acid, were found in the different lipid classes of guinea-pig uterus and plasma on Days 7 and 15 of the oestrous cycle. Of the total arachidonic acid in the uterus, 93% was esterified to uterine phospholipids, of which 80% was bound to phosphatidylcholine and phosphatidylethanolamine. There was a significant decrease in the quantity of arachidonic acid bound to phosphatidylcholine between Days 7 and 15 of the oestrous cycle. Less than 0\m=.\1% of the uterine arachidonic acid was present in the unesterified form. It is suggested that phosphatidylcholine may form the source of phosphatidyl for uterine prostaglandin synthesis in the guinea-pig.

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Section: Methodssupporting

confidence: 53%

Section: Methodsmentioning

confidence: 99%

Distribution of arachidonic acid and other fatty acids in the lipids of guinea-pig uterus and plasma in relation to uterine prostaglandin synthesis

Ha¹,

Nl²

1981

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“…Several metabolic studies followed which established that oestrogenic hormones were responsible for the stimulation of uterine lipid production, and in a review on the subject, Beali (1972) acknowledged that "this increment is probably secondary to an increase in protein (Gorski & Nicolette, 1963) and RNA (Gorski, 1964)". Such active lipid synthesis must be preceded by the stimulation of various enzymes of lipid metabolism but information about the structure and function of individual lipids and their regulatory enzymes in animals with menstrual cycles is still scarce.…”

Section: Introductionmentioning

confidence: 99%

Cyclic changes in phospholipid content and composition in human endometrium during the menstrual cycle

Montané¹,

Pérez-Ballester²

1985

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Summary. A significant increase in total phospholipid content of the endometrium took place during the secretory phase of the human menstrual cycle (26% increase from mi d\x=req-\ proliferative to premenstrual stage). The major phospholipid, phosphatidylcholine, was increased by 30%, whereas phosphatidylethanolamine was unchanged. Phosphatidyl-serine and -inositol underwent the largest percentage increases (40%). Phosphatidic acid levels were the only ones to decrease ( \m=-\ 52%), a finding consistent with the role of this lipid as precursor of the increased phospholipids. The changes did not markedly affect phospholipid composition, except for a significant decrease in the proportions of phosphatidate and phosphatidylethanolamine. Arachidonate and eicosatrienoate (n-6) were the major polyunsaturated fatty acids. C22 tetra-, penta-and hexa-enoic fatty acids of the n-3 and n-4 families were also present in all major endometrial glycerophospholipids throughout the cycle. The mass changes in phospholipids during the cycle occurred without alteration of their fatty acid composition.

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“…The fatty acid composition of the uterus and fetuses from gilts killed 30 days after breeding at puberty was not affected by the soybean oil (Beall 1972 During a factorial experiment (Friend 1977) For personal use only. fMeanofeightsampleststandarddeviation.…”

mentioning

confidence: 99%

Fatty Acid Composition of the Pig Uterus, Fetus and Belly Fat

Friend¹,

Elliot²

1979

Can. J. Anim. Sci.

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The fatty acid composition of the uterus and fetuses from gilts killed 30 days after breeding at puberty was not affected by the soybean oil content (0–20%) of the diet given to the gilts before breeding. Differences in fatty acid profile were evident in belly fat samples taken from the same gilts. Although the belly fat contained linolenic acid, it did not appear to contain arachidonic acid as did the uterus and fetuses.

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Uterine lipid metabolism—a review of the literature

Cited by 12 publications

References 85 publications

Distribution of arachidonic acid and other fatty acids in the lipids of guinea-pig uterus and plasma in relation to uterine prostaglandin synthesis

Distribution of arachidonic acid and other fatty acids in the lipids of guinea-pig uterus and plasma in relation to uterine prostaglandin synthesis

Cyclic changes in phospholipid content and composition in human endometrium during the menstrual cycle

Fatty Acid Composition of the Pig Uterus, Fetus and Belly Fat

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