Utility of laboratory tests in B-CLL patients in different clinical stages

Rusak, Małgorzata; Osada, Joanna; Pawlus, Joanna; Chociej-Stypułkowska, Joanna; Dąbrowska, Milena; Kłoczko, Janusz

doi:10.1007/s12185-011-0862-3

Cited by 5 publications

(6 citation statements)

References 13 publications

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“…Clinicians are demanding to develop very accurate prognostic information for each patient in that CLL is common and heteroplasmy. 22,23 The clinical issue is underlined by 3 aspects: (1) more than 50% CLL patients are diagnosed at early stage [24][25][26] ; (2) current usage of the Rai staging system is not helpful in predicting disease progression and time point of treatment of patients in early stages (Rai 0-1); [25][26][27] and (3) a fair amount of patients rapidly died of this disease, meanwhile others can survive for years, often without the need for treatment. 26,28 According to the data in our center, 45% to 50% of early-stage CLL patients get treatment indication in the 4-year follow-up at the initial of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Definition of disease‐progression risk stratification in untreated chronic lymphocytic leukemia using combined clinical, molecular and virological variables

Qin

Fan

Liang

et al. 2018

Hematological Oncology

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Prognoses of persons with chronic lymphocytic leukemia (CLL) including time-to-therapy (TTT) and survival is heterogeneous. Risk factors and predictive scoring systems are mostly developed in persons of predominately European descent with CLL. Whether these systems accurately predict TTT and survival of Han Chinese with CLL is unknown. We interrogated clinical and laboratory data from 334 newly diagnosed, untreated Chinese CLL without treatment indication upon diagnosis to identify variables associated with TTT and develop a prognostic score. Binet stage, blood lymphocyte level, TP53 abnormality, unmutated IGHV, prior HBV, and EBV infections were independently associated with TTT in multivariate analyses. We constructed a prognostic score dividing subjects into cohorts with low, intermediate, and high risk from diagnosis to TTT. Median TTTs were 139 months (range, 85-189 months), 25 months (12-38 months), and 4 months (1-7 months; P-value for trend <0.001). We identified variables associated with TTT in Chinese with CLL with no treatment indication and developed a predictive model for survival. Some variables associated with TTT are similar to those of persons of predominately European descent, whereas others, such as HBV and/or EBV infections, operate in Chinese and Europeans but are not currently included in prognostic and predictive staging systems in persons of European descent. They should be investigated.

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Section: Discussionmentioning

confidence: 99%

Definition of disease‐progression risk stratification in untreated chronic lymphocytic leukemia using combined clinical, molecular and virological variables

Qin

Fan

Liang

et al. 2018

Hematological Oncology

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“…Além de alta linfocitose clonal, anemia, trombocitopenia, pequeno número de manchas Gumprecht, baixa atividade apoptótica e elevada porcentagem de células CD38 e ZAP-70 positivas podem servir como fatores prognósticos que são complementares uns aos outros e podem ajudar a identificar pacientes com um curso desfavorável da LLC-B e avaliar a resposta ao tratamento já numa fase precoce de avanço da neoplasia (RUSAK et al, 2011).…”

Section: Marcadores Biológicos E Prognósticounclassified

“…Score da CMF para diagnóstico de LLC Deve ser lembrado que a expressão de CD38 tende a flutuar no decorrer da doença. Em estudo realizado ainda pelo mesmo autor, os resultados também demonstram uma correlação fortemente negativa da expressão de CD38 e ZAP-70 (zeta-associated protein 70)em linfócitos da LLC-B, com a vulnerabilidade dos mesmos a apoptose(RUSAK et al, 2011). Classificação das doenças linfoides crônicas, segundo a linhagem celular de origem…”

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“…Uma correlação entre maior infiltração na MO e alta expressão de ZAP-70 foi observada em pacientes com LLC, de modo que o papel de ZAP-70 na infiltração medular por linfócitos malignos pode potencialmente ser explorado para o desenvolvimento de novos tratamentos.O recurso diagnóstico conveniente de ZAP-70 é o fato de que, ao contrário de CD38, a sua expressão permanece estável durante todo o curso da doença. Acredita-se que níveis elevados de ZAP-70 indicam uma rápida progressão da LLC e redução no tempo médio de sobrevida, independentemente do estágio da doença no momento da implantação do tratamento(RUSAK et al, 2011). Resultados do estudo deRusak et al (2011) também demonstraram uma correlação fortemente negativa da expressão de CD38 e ZAP-70 com a vulnerabilidade dos linfócitos leucêmicos a apoptose.Tem sido relatado que muitos fatores de mau prognóstico (incluindo CD38, ZAP-70, B2M, estado de mutação IGHV e deleções 11q23 ou 17p53) podem ajudar a identificar pacientes de alto risco em estágios iniciais da LLC.…”

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Métodos laboratoriais utilizados para o diagnóstico da leucemia linfoide crônica: uma revisão

Lira

Pereira

2019

BJHR

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“…The major advantage of the use of the CD marker system is that, even without knowing the actual molecular identity or function of a given marker, this specific labeling and the related Data taken from [86][87][88][89][90][91][92][93].…”

Section: Differentiation Markers Cd10mentioning

confidence: 99%

Cell Surface Membrane Proteins as Personalized Biomarkers: Where we Stand and Where we are Headed

et al. 2013

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Personalized medicine requires the development of a wide array of biomarker diagnostic assays, reflecting individual variations and thus allowing tailored therapeutic interventions. Membrane proteins comprise approximately 30% of total human proteins; they play a key role in various physiological functions and pathological conditions, although, currently, only a limited number of membrane proteins are applied as biomarkers. In many normal tissues, cell surface membrane proteins are not easily accessible for diagnostic sampling, and tumor-derived membrane preparations – while serving as potential tumor biomarkers – may not reflect physiological protein expression. In addition to post-translational modifications, which may include glycosylation, phosphorylation and lipid modifications, the trafficking of membrane proteins is also regulated. Moreover, a tight cellular quality control monitors membrane protein maturation, and continuous removal and reinsertion, involving special signaling systems, occurs in many cases. However, cell surface membrane proteins already serve as valuable prognostic and predicative biomarkers, for example, in hematological and immunological diseases, by the determination of the cluster of differentiation markers. In this review, we demonstrate the relevance of cell surface membrane biomarkers in various diseases and call attention to the potential application of red blood cell (erythrocyte) membrane proteins in this regard. Surprisingly, red blood cells express hundreds of membrane proteins, which seem to reflect a general genetic and regulatory background, and may serve as relatively stable and easily accessible personalized membrane biomarkers. Quantitative membrane protein detection in red blood cells by flow cytometry may bring a breakthrough in this regard.

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Utility of laboratory tests in B-CLL patients in different clinical stages

Cited by 5 publications

References 13 publications

Definition of disease‐progression risk stratification in untreated chronic lymphocytic leukemia using combined clinical, molecular and virological variables

Definition of disease‐progression risk stratification in untreated chronic lymphocytic leukemia using combined clinical, molecular and virological variables

Métodos laboratoriais utilizados para o diagnóstico da leucemia linfoide crônica: uma revisão

Cell Surface Membrane Proteins as Personalized Biomarkers: Where we Stand and Where we are Headed

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