Utility of serum Campylobacter specific antibodies in determining prior Campylobacter infection in neurological disease

Taylor, Bruce; Williamson, Jan; Jones, David; Coleman, David C.; Luck, J; McGregor, Alistair

doi:10.1016/j.jocn.2006.01.040

Cited by 6 publications

(4 citation statements)

References 31 publications

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“…In our study four asymptomatic C. jejuni-positive cases were encountered. [18] The commonest subtype of GBS in our study was AIDP, although patients with AMAN were considerably common. Among the C. jejuni-positive GBS cases 66% were of the axonal subtype (AMAN and AMSAN).…”

Section: Discussionmentioning

confidence: 62%

Campylobacter jejuni infection in Guillain-Barré syndrome: A prospective case control study in a tertiary care hospital

et al. 2011

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Section: Discussionmentioning

confidence: 62%

Campylobacter jejuni infection in Guillain-Barré syndrome: A prospective case control study in a tertiary care hospital

et al. 2011

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“…Campylobacter jejuni (C. jejuni), which is one of the leading factors associated with the development of GBS, was significantly associated with the development of GBS in all seven studies that studied this association [33][34][35][36][37]. Pneumococcal vaccine, yellow fever and human papillomavirus (HPV) in girls were other vaccines reported in the studies; none were associated with the occurrence of GBS [38][39][40][41].…”

Section: Resultsmentioning

confidence: 99%

Systematic review of factors associated with the development of Guillain–Barré syndrome 2007–2017: what has changed?

Wachira

Peixoto

Oliveira

2018

Tropical Med Int Health

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Objective The objective of this study was to describe the factors associated with the development of Guillain–Barré syndrome, both infectious and non‐infectious, during and after the A(H1N1) influenza pandemic in 2009 and the recent Zika virus epidemic in the Americas. Method Systematic review of literature on factors associated with the development of the Guillain–Barré syndrome published between 2007 and 2017 listed in EBSCO, MEDLINE and LILACS databases. The quality of the studies was evaluated using the Newcastle Ottawa Scale. Results Thirty‐four articles met inclusion criteria and were selected for analysis. Their quality was considered good in relation to most of the items evaluated. Many aetiological agents had the results of association with Guillain–Barré syndrome, among them Campylobacter jejuni, influenza vaccine – both pandemic and seasonal vaccines, respiratory infection, gastrointestinal infection among others. The aetiological agents found are, in most part, the same reported prior to the study period. The association with surgeries, chikungunya virus (CHIKV), Zika virus and quadrivalent human papillomavirus vaccine stand out as new aetiological agents in the list of the various possible agents that trigger Guillain–Barré syndrome reported in the study period. There were no Brazilian studies identified during this period. Conclusions The results of the review reaffirmed C. jejuni as the major trigger of GBS, whereas the association of influenza vaccines and GBS is less clear; Zika virus infection in association with GBS was found in only one study.

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“…In addition, most serological tests have a high false-negative rate and for those individuals that do seroconvert the antibody titer quickly decreases after a few months [ 47 , 48 ]. Studies on acute Guillain-Barré syndrome, a disease often triggered by Campylobacter infections have found up to 80% of cases display serological evidence of Campylobacter , but it is unclear whether the negative cases were triggered by Campylobacter or other infections [ 49 ], and false positives have been observed [ 50 ]. Regarding the New Zealand patient, this could be explained by a number of scenarios including: the Campylobacter was not the cause of any pathology and had not been presented to the immune system or triggered an immune response; the Campylobacter contributed to the diarrheal episodes but the patient was unable to form an immune response sufficient to remove the bacteria or be detected using the serological method described.…”

Section: Discussionmentioning

confidence: 99%

Genomic adaptations of Campylobacter jejuni to long-term human colonization

et al. 2021

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Background Campylobacter is a genus of bacteria that has been isolated from the gastrointestinal tract of humans and animals, and the environments they inhabit around the world. Campylobacter adapt to new environments by changes in their gene content and expression, but little is known about how they adapt to long-term human colonization. In this study, the genomes of 31 isolates from a New Zealand patient and 22 isolates from a United Kingdom patient belonging to Campylobacter jejuni sequence type 45 (ST45) were compared with 209 ST45 genomes from other sources to identify the mechanisms by which Campylobacter adapts to long-term human colonization. In addition, the New Zealand patient had their microbiota investigated using 16S rRNA metabarcoding, and their level of inflammation and immunosuppression analyzed using biochemical tests, to determine how Campylobacter adapts to a changing gastrointestinal tract. Results There was some evidence that long-term colonization led to genome degradation, but more evidence that Campylobacter adapted through the accumulation of non-synonymous single nucleotide polymorphisms (SNPs) and frameshifts in genes involved in cell motility, signal transduction and the major outer membrane protein (MOMP). The New Zealand patient also displayed considerable variation in their microbiome, inflammation and immunosuppression over five months, and the Campylobacter collected from this patient could be divided into two subpopulations, the proportion of which correlated with the amount of gastrointestinal inflammation. Conclusions This study demonstrates how genomics, phylogenetics, 16S rRNA metabarcoding and biochemical markers can provide insight into how Campylobacter adapts to changing environments within human hosts. This study also demonstrates that long-term human colonization selects for changes in Campylobacter genes involved in cell motility, signal transduction and the MOMP; and that genetically distinct subpopulations of Campylobacter evolve to adapt to the changing gastrointestinal environment.

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Utility of serum Campylobacter specific antibodies in determining prior Campylobacter infection in neurological disease

Cited by 6 publications

References 31 publications

Campylobacter jejuni infection in Guillain-Barré syndrome: A prospective case control study in a tertiary care hospital

Campylobacter jejuni infection in Guillain-Barré syndrome: A prospective case control study in a tertiary care hospital

Systematic review of factors associated with the development of Guillain–Barré syndrome 2007–2017: what has changed?

Genomic adaptations of Campylobacter jejuni to long-term human colonization

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