Utility of Tissue Doppler and Strain Rate Imaging in the Early Detection of Trastuzumab and Anthracycline Mediated Cardiomyopathy

Jassal, Davinder S.; Han, Song-Yee; Hans, Cecilia; Sharma, Anita; Fang, Tielan; Ahmadie, Roien; Lytwyn, Matthew; Walker, Jonathan R.; Bhalla, Raveen S.; Czarnecki, Andrew; Moussa, Tarek; Singal, Pawan K.

doi:10.1016/j.echo.2009.01.016

Cited by 94 publications

(92 citation statements)

References 32 publications

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“…[8] DTI associated with SRI has shown its value in early detection of epirubicin-induced cardiotoxicity, and a measurable SR peak depression has been regarded as the earliest sign of left ventricular regional systolic dysfunction in epirubicintreated patients long before a clinical manifestation of heart failure. [9] Our study also showed that a subtle systolic decline of the SR peak appeared after an epirubicin dose of 200 mg/m 2 , but the LVEF remained unchanged in the salidroside and placebo groups between baseline and epirubicin chemotherapy.…”

Section: Discussionmentioning

confidence: 55%

Protective Effects of Salidroside on Epirubicin-Induced Early Left Ventricular Regional Systolic Dysfunction in Patients with Breast Cancer

et al. 2012

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Background: Salidroside [2-(4-hydroxyphenyl)ethyl-b-D-glucopyranoside], one of the most potent ingredients extracted from the plant Rhodiola rosea L., has been shown to have a cardiovascular protective effect as an antioxidant, and early treatment of epirubicin-induced cardiotoxicity has been the focus of clinical chemotherapy in patients with breast cancer. However, the cardioprotective effects of salidroside on epirubicin-induced cardiotoxicity, especially early left ventricular regional systolic dysfunction, have to date been sparsely investigated. Objective: The aim of this study was to investigate the protective effects of salidroside in preventing early left ventricular regional systolic dysfunction induced by epirubicin. Methods: Sixty patients with histologically confirmed breast cancer were enrolled. Eligible patients were randomized to receive salidroside (600 mg/day; n = 30) or placebo (n = 30) starting 1 week before chemotherapy. Patients were investigated by means of echocardiography and strain rate (SR) imaging. We also measured plasma concentrations of reactive oxygen species (ROS). All parameters were assessed at baseline and 7 days after each new epirubicin dose of 100 mg/m 2 . Results: A decline of the SR peak was observed at an epirubicin dose of 200 mg/m 2 , with no significant differences between salidroside and placebo (1.35 -0.36 vs 1.42 -0.49/second). At growing cumulative doses of epirubicin, the SR normalized only with salidroside, showing a significant difference in comparison with placebo at epirubicin doses of 300 mg/m 2 (1.67 -0.43 vs 1.32 -0.53/second, p < 0.05) and 400 mg/m 2 (1.68 -0.29 vs 1.40 -0.23/second, p < 0.05). Moreover, a significant increase in plasma concentrations of ROS was found with placebo, but they remained unchanged with salidroside.

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Section: Discussionmentioning

confidence: 55%

Protective Effects of Salidroside on Epirubicin-Induced Early Left Ventricular Regional Systolic Dysfunction in Patients with Breast Cancer

et al. 2012

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“…21,117 In the emerging field of Cardio-Oncology, a number of basic science studies have evaluated the role of cardiac imaging for the early detection of LV systolic dysfunction due to DOX+TRZ. [12][13][14]118 In an acute murine model of DOX mediated carditoxicity, Neilan et al Previous studies have also evaluated the potential therapeutic effects of other cardioprotective agents. In particular, prior investigations have characterized the potential cardioprotective effects of iron chelating agents, β-blockers, ACE inhibitors, and anti-oxidants including Probucol.…”

Section: Cardiovascular Remodeling: Echocardiographymentioning

confidence: 99%

“…Many studies have revealed that an increase in oxidative stress, due to the production of chemotherapy-induced free radicals, plays a pivotal role in damaging cardiomyocytes. [12][13][14] Given this proposed mechanism of damage, recent efforts to attenuate chemotherapy induced cardiac dysfunction have led to investigations into the use of prophylactic antioxidant treatment. N-acetylcysteine (NAC) is an antioxidant which was seen to significantly reduce free radical induced damage in cardiomyocytes in vitro, but proved to be ineffective in vivo.…”

Section: Breast Cancer Therapy and Cardiac Damagementioning

confidence: 99%

“…12,13 In addition, the GE EchoPAC PC program was also used to calculate fractional shortening (FS) as described by equation 2. …”

Section: Echocardiographymentioning

confidence: 99%

“…All of the mice were imaged in the parasternal long axis (PLAX) and short axis (SAX) views, as previously described. 12,13,110,111 Images were post-processed offline using the EchoPAC PC software (Vivid 7, version 11.2, GE Medical Systems, Milwaukee, WI, US). Images acquired in the PLAX view were used to calculate LVEF by manually tracing LV end-diastolic and end-systolic volumes (Equation 1).…”

Section: Echocardiographymentioning

confidence: 99%

See 2 more Smart Citations

The Cardioprotective Role of Naca in the Prevention of Doxorubicin and Trastuzumab Mediated Cardiac Dysfunction

Goyal

Bordun

Premecz

et al. 2014

Canadian Journal of Cardiology

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Echocardiography in Mice

et al. 2011

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Murine models have been utilized with increasing frequency mainly due to availability of genetically engineered models. With advancement in high spatial and temporal resolution, echocardiography is used extensively for the evaluation of cardiovascular function in murine models of cardiovascular disease. This review summarizes the general applications and methods involved in echocardiography used to study mouse models for cardiovascular research, based on 20 years of experience in our laboratory. The goal of this article is to provide a practical guide to the use of echo techniques in mice to evaluate cardiac systolic and diastolic function.

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Utility of Tissue Doppler and Strain Rate Imaging in the Early Detection of Trastuzumab and Anthracycline Mediated Cardiomyopathy

Cited by 94 publications

References 32 publications

Protective Effects of Salidroside on Epirubicin-Induced Early Left Ventricular Regional Systolic Dysfunction in Patients with Breast Cancer

Protective Effects of Salidroside on Epirubicin-Induced Early Left Ventricular Regional Systolic Dysfunction in Patients with Breast Cancer

The Cardioprotective Role of Naca in the Prevention of Doxorubicin and Trastuzumab Mediated Cardiac Dysfunction

Echocardiography in Mice

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