Vaccinating Calves in the Face of Maternal Antibodies

Respuesta inmune en neonatos bovinos de madres vacunadas y no vacunadas con bacterina contra neumoenteritis

“…En vacas, a mayor número de partos mayores valores séricos de proteína total, debido principalmente a las inmunoglobulinas, ya que el sistema inmunológico de las vacas multíparas ha estado en contacto con más patógenos, y por lo tanto tienen una mayor cantidad de anticuerpos (Bobbo et al, 2017). Las diferencias entre tratamientos (Tabla 1) pueden estar relacionadas con la respuesta inmune a la bacterina; no obstante, T2 recibió una dosis y T3 dos, mostrando este, contradictoriamente, una menor concentración de globulinas, probablemente por bloqueo materno a la respuesta exógena inducida (Windeyer y Gamsjäger, 2019). Tabla 1.…”

“…Las globulinas séricas en las madres mostraron el valor más bajo en T3 con 37,67 g/L, mientras que en T2 se presentó el mayor con 48,32 g/L; los valores conocidos están entre 30 y 34,8 g/L (Kaneko et al, 2008). Los valores hallados en los tratamientos con vacuna son superiores (Tabla 1) al valor del grupo control, pudiendo indicar efecto de la bacterina; sin embargo, el T3 que recibió dos dosis de vacuna, presentó un valor más bajo que T2 posiblemente por inhibición asociada al bloqueo materno (Windeyer y Gamsjäger, 2019). En general, Roa-Vega et al, (2017) informan valores de 42,86±3,47 para globulinas en vacas recién paridas con suplementación proteica.…”

The adaptive potential of newborn calves under conditions of technogenic anthropobiocenosis

“…Under the influence of modern ecosystem conditions, first of all, placental dysfunction occurs, placental insufficiency develops, which leads to a violation of the normal functioning of the "mother -placenta -fetus" system, which is manifested in decrease in the protective and adaptive capabilities of the fetus [10][11][12]. The study of the fetal part of the placenta immediately after birth allows us to determine the features of the body status of the newborn animal, the presence of pathological changes in the uterine mucosa, as well as the genetic parental inferiority [13][14][15].…”

“…The study of the fetal part of the placenta immediately after birth allows us to determine the features of the body status of the newborn animal, the presence of pathological changes in the uterine mucosa, as well as the genetic parental inferiority [13][14][15]. One should strive to create conditions that would facilitate the full implementation of the genetic potential of animals and the efficient functioning of the system "motherplacenta -fetus", and to maximum satisfaction of both: production performance of livestock and biological needs of the animals [7,8,10]. Therefore, in ecological terms, it is necessary to move from the existing traditional concept: sick animal -diagnosis -therapy, to a new global problem: animal population -habitat -preventive measures [4].…”

Effectiveness of two intranasal vaccines for the control of bovine respiratory disease in newborn beef calves: A randomized non-inferiority multicentre field trial

“…In addition, maternally derived antibodies (MDA), which are transmitted through colostrum and remain present for up to six months, can interfere negatively with immunization of newborn calves after vaccination ( Ellis et al, 2014 , Kimman et al, 1989 ). To overcome interference between parenteral vaccines and MDA, intranasal vaccination strategies using modified live vaccines for respiratory diseases have been developed and used widely for many years ( Windeyer and Gamsjäger, 2019 ). Intranasal vaccination is able to induce protective immunity in newborn calves despite the presence of MDA by priming mucosal immunization of the upper respiratory tract whereas protective immunity is inconsistent after parenteral vaccinations ( Osman et al, 2018 ).…”