Vaccine againstHelicobacter pylori: Inevitable approach

Abstract

Over three decades have passed since the discovery of Helicobacter pylori (H. pylori), and yet many questions about its treatment remain unanswered. For example, there is no certainty regarding continued use of current antibiotic therapy against H. pylori. The bad news is that even combined regimens are also unable to eradicate bacterial colonization. The worst problem with H. pylori chemotherapy is that even if we identify the most successful regimen, it cannot eliminate the risk of re-infection. This problem is further complicated by the fact that clinicians have no information as to whether probiotics are useful or not. Moreover, to date, we have no large scale produced vaccine effective against H. pylori. Due to the relatively rapid and abundant dissemination of guidelines globally reported concerning management of gastric cancer prevention and therapeutic regimens, clinicians may choose a vaccine as better effective weapon against H. pylori. Therefore, a radical shift in adopted strategies is needed to guide ultimate decisions regarding H. pylori management. In light of failures in vaccine projects, we should identify better vaccine design targeting conserved/essential genes. The unique character and persistence of H. pylori pose obstacles to making an effective vaccine. Preferably, in developing countries, the best reasonable and logical approach is to recommend prophylactic H. pylori vaccine among children as an obligatory national program to limit primary colonization. Trying to produce a therapeutic vaccine would be postponed until later. In reality, we should not forget to prescribe narrow spectrum antibiotics. In the current review, I draw a route to define the best adopted strategy against this rogue bacterium.

Helicobacter pylori seropositivity and its association with incident all‐cause and Alzheimer's disease dementia in large national surveys

“…Furthermore, given race- and sex-specific differences in H. pylori seroprevalence [19,26], there is a need to test longitudinal associations between H. pylori status and cognitive outcomes across those sociodemographic factors. Finally, there are effective ways to eradicate H. pylori , and research is under way to develop vaccines, which strengthen the rationale to study this modifiable factor [35]. …”

Lactobacillus plantarum induces apoptosis in gastric cancer cells via modulation of signaling pathways in Helicobacter pylori

“…11 Various groups in the world work to construct efficient vaccine(s) against the H. pylori infection and several of these deigned constructs are being evaluated in different clinical trial phases. 12,13 More recently, probiotics have been considered as a novel tool for controlling H. pylori infections. 1,14 Based on the definition of the Food and Agriculture Organization (FAO) and the World Health Organization (WHO), probiotics are live microorganisms that can confer beneficial health effects on their hosts if they are administered in suitable amounts.…”

Progress in Use of Natural Products and Their Active Components against <i>Helicobacter pylori</i>

“…At present there is no large scale production of an effective vaccine against H. pylori available at the market [5]; therefore, other alternative approaches such as natural products, the central topic of this review, as well as phage therapies tested on Campylobacter species [6] and phototherapy [7] should be tried.…”