Vaccine efficacy of recombinant BmVDAC on Rhipicephalus microplus fed on Babesia bigemina-infected and uninfected cattle

Ortega-Sánchez, Reyna; Camacho-Nuez, Minerva; Castañeda-Ortiz, Elizabeth J.; Martínez-Benitez, Máximo; Hernández-Silva, Diego Josimar; Aguilar-Tipacamú, Gabriela; Mosqueda, Juan

doi:10.1016/j.vaccine.2019.12.040

Cited by 11 publications

(4 citation statements)

References 51 publications

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“…Among cattle immunized with recombinant BmVDAC, the efficacy against R. microplus was found to be 82%. Interestingly, when ticks were infected with B. bigemina, the reported efficacy of recombinant BmVDAC decreased to 34% (ORTEGA-SANCHEZ et al, 2020).…”

Section: Potential Antigens For the Control Of R Microplusmentioning

confidence: 99%

Vaccination against Rhipicephalusmicroplus: an alternative to chemical control?

Silva,

Ali,

Termignoni

et al. 2024

Cienc. Rural

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Rhipicephalus (Boophilus) microplus is a hard tick endemic in livestock-growing regions and causes economic losses in the largest beef-producing countries, including Brazil, Mexico, Argentina, Australia and Uruguay. The use of chemical acaricides is still the main strategy to control R. microplusinfestations. Nevertheless, immunological control of R. microplus with an anti-tick vaccine is a suitable alternative and has manifold advantages because it can avoid drug-resistance and the presence of acaricide residues in milk, beef and in the environment. Indeed, vaccines based on the Bm86 antigen have had relative commercial and technical success to control R. microplus in some regions. Although, the efficacy of such vaccines varies among tick populations and is insufficient to provide an acceptable level of protection. Therefore, the need to search for better antigens is impelling. This review focused on the restrictions imposed on the use of acaricides in Brazil and in the European Union, as well as on the impacts of Bm86-based vaccines on R. microplus control. The efficacy of experimental anti-tick vaccines (based on subolesin, glutathione S-transferase, ferritin 2; voltage-dependent anion channel; aquaporin, 60 S acidic ribosomal protein, metalloprotease and trypsin) that can elicit an immune response against the physiological functions of various ticks is discussed.

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Section: Potential Antigens For the Control Of R Microplusmentioning

confidence: 99%

Vaccination against Rhipicephalusmicroplus: an alternative to chemical control?

Silva,

Ali,

Termignoni

et al. 2024

Cienc. Rural

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“…Additionally, vaccines can complement other ixodid control tactics with the aim of mitigating the development of resistance to acaricides [ 250 ] Vaccines can be designed to deploy multiple antigens, enabling protection for a wide range of host species against multiple ixodid species [ 251 ]. As an example of current efforts to develop anti-ixodid vaccines, candidate vaccines are being investigated with the goal of providing prophylactic protection of cattle from R. microplus [ 252 ], while recent efforts using recombinant antitick vaccines afforded nearly 82% efficacy against tick infestation [ 253 ]. Additional vaccine development opportunities exist, with a current focus on improving identification and characterization of ixodid antigens that can then be generated in the laboratory [ 254 ].…”

Section: Vaccinesmentioning

confidence: 99%

Integrative Alternative Tactics for Ixodid Control

Showler

Saelao

2022

Insects

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Ixodids (hard ticks), ectoparasitic arthropods that vector the causal agents of many serious diseases of humans, domestic animals, and wildlife, have become increasingly difficult to control because of the development of resistance against commonly applied synthetic chemical-based acaricides. Resistance has prompted searches for alternative, nonconventional control tactics that can be used as part of integrated ixodid management strategies and for mitigating resistance to conventional acaricides. The quest for alternative control tactics has involved research on various techniques, each influenced by many factors, that have achieved different degrees of success. Alternative approaches include cultural practices, ingested and injected medications, biological control, animal- and plant-based substances, growth regulators, and inert desiccant dusts. Research on biological control of ixodids has mainly focused on predators, parasitoid wasps, infective nematodes, and pathogenic bacteria and fungi. Studies on animal-based substances have been relatively limited, but research on botanicals has been extensive, including whole plant, extract, and essential oil effects on ixodid mortality, behavior, and reproduction. The inert dusts kaolin, silica gel, perlite, and diatomaceous earth are lethal to ixodids, and they are impervious to environmental degradation, unlike chemical-based toxins, remaining effective until physically removed.

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“…Putatively concealed 7 Willadsen et al, 1996;McKenna et al, 1998;Andreotti et al, 2002;Patarroyo et al, 2002;Hajdusek et al, 2010;Almazán et al, 2012;Parizi et al, 2012;Seixas et al, 2012;Díaz-Martín et al, 2013;Merino et al, 2013;Ali et al, 2014;Guerrero et al, 2014;Radulović et al, 2014;Tirloni et al, 2014;Richards et al, 2015;Rodríguez-Mallon et al, 2015;Tirloni et al, 2015;Kumar et al, 2017;Maruyama et al, 2017;Tirloni et al, 2017;Csordas et al, 2018;Kim et al, 2020;Ortega-Sánchez et al, 2020 Acknowledgements BFL received a scholarship from CAPES, Brasil.…”

Section: Categoriesmentioning

confidence: 99%