Vaccine-Induced Autoimmunity in the Dog

HogenEsch, Harm; Azcona-Olivera, Juan I.; Scott-Moncrieff, Catharine; Snyder, Paul W.; Glickman, Larry T.

doi:10.1016/s0065-3519(99)80056-1

Cited by 67 publications

(41 citation statements)

References 17 publications

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“…5 In animal models, it is apparent that commonly given vaccines induce a variety of autoantibodies but no frank autoimmune illness. 6 In genetically predisposed animals, though, it has been reported that immunization with cytomegalovirus glycoprotein gB can trigger the development or acceleration of an autoimmune disorder. 7 In humans, it has been reported that natural infection or vaccination against measles and/or mumps could have an inhibitory effect on the development of thyroid autoantibodies, but no evidence was found that measles, mumps, and rubella vaccination might trigger autoimmunity.…”

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confidence: 99%

No Evidence of Autoimmunity in 6-Year-Old Children Immunized at Birth With Recombinant Hepatitis B Vaccine

et al. 2002

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ABSTRACT. Objectives. Taking into account that genetic predisposition, marked by human leukocyte antigen (HLA) class I and II genes, augments the probability of developing an autoimmune disorder after a triggering vaccination, as largely debated, we investigated the frequency of autoantibody production after recombinant hepatitis B vaccine (rHBv) in 6-year-old children immunized at birth to evaluate an association between autoimmune disorders and hepatitis B virus vaccination.Methods. We investigated the presence of autoantibodies in 210 6-year-old children who were immunized at birth with rHBv: 200 showed anti-hepatitis B surface antigen concentrations >10 mUI/mL at seroconversion (responders), and 10 were nonresponders. Data were compared with those obtained in 109 unvaccinated children. All participants were screened for the presence of antinuclear antibodies (ANAs), anti-DNA, antimitochondrial, anti-liver/kidney microsomal, antireticulin, antismooth muscle (SMA), and antiribosomal antibodies. All participants were also screened for the presence of antithyroid antibodies, such as antithyroglobulin and antiperoxidase, and for antibodies found in type 1 diabetes, such as tyrosine phosphatase (IA-2A) and glutamic acid decarboxylase (GADA). HLA typing was extended to all 10 nonresponders.Results. Autoantibodies were found in 16 of the 200 responders: ANAs were found in 12 (6%), smooth muscle antibodies were found in 4 (2.0%), and antireticulin antibodies and endomysial antibodies were found in 1 girl with ANAs. Antithyroid antibodies, IA-2A, and GADA were not present in any of the participants. No significant difference was found in the frequency of autoantibodies between vaccinated and control children. Three of the 10 nonresponder children were SMA-positive (30% vs 2% of responders); they also carried the supratype HLA-C4AQ0,DRB1*0301,DQB1*02. A family history for autoimmune disorders was present in 3 (18%; 95% confidence interval [CI]: 4.0%-45.6%) of the 16 responder infants with autoantibodies, in 15 (8.4%; 95% CI: 4.6%-13.1%) of responder children without autoantibodies, and in 1 (10%) of the 10 nonsreponder children.Conclusions. From our data, vaccination with rHBv given during the neonatal period does not seem to increase autoantibody production in a 6-year-old children. Autoantibodies, referred to as natural autoantibodies, can be found in healthy participants, but their significance is unclear. These autoantibodies often cross-react with bacteria or tumor antigens, suggesting their importance in innate immunity. It has been demonstrated in an animal model that self-antigen can promote B-cell accumulation, and that a significant proportion of natural autoantibodies is the product of this self-antigen-dependent process. Consequently, it has been speculated that self-antigens play a positive role in recruiting B cells as a part of innate immunity, but this process carries a potential risk for unregulated growth.Spreading of the immune response is a common theme in organ-specific and systemis autoimmune dise...

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confidence: 99%

No Evidence of Autoimmunity in 6-Year-Old Children Immunized at Birth With Recombinant Hepatitis B Vaccine

et al. 2002

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“…Puppies immunized with the rabies vaccine and a multivalent canine vaccine were compared to unvaccinated control puppies [103]. The vaccinated puppies, but not the unvaccinated ones, developed autoantibodies to their own collagen.…”

Section: Evidence For a Role For Collagen In Vaccine Adverse Reactionsmentioning

confidence: 99%

Glyphosate pathways to modern diseases VI: Prions, amyloidoses and autoimmune neurological diseases

Samsel¹,

Seneff²

2017

JBPC

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“…As attention has been drawn to the rare, yet possible, post-vaccination complications, research performed on animals revealed the emergence of various autoantibodies, including those associated with SLE (in dogs) [11]. In studies on salmon, oil adjuvant administered to peritoneum led not only to the formation of antinuclear antibodies, antibodies to β2 glycoprotein I (β2GPI) and anti-ferritin antibodies, but also to the occurrence of granulomatous disease of the peritoneum and liver as well as glomerulonephritis and thromboembolic complications [12].…”

Section: S T R E S Z C Z E N I Ementioning

confidence: 99%