Vaccine-induced thrombotic thrombocytopenia following coronavirus vaccine: A narrative review

Ahmed, Syed Hassan; Shaikh, Taha Gul; Waseem, Summaiyya; Qadir, Nashwa Abdul; Yousaf, Zohaib; Ullah, Irfan

doi:10.1016/j.amsu.2021.102988

Cited by 14 publications

(19 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A narrative review paper found that the association between COVID-19 vaccination and the incidence of thrombosis is low. Nonetheless, smokers and the elderly still require special attention [ 16 ]. Despite the strength of the relationship, a conclusion about the safety of COVID-19 vaccination has yet to be drawn [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Upper Limb Ischemia Due to Arterial Thrombosis after COVID-19 Vaccination

Alsmady

Al-Qaryouti

Sultan

et al. 2022

Case Reports in Medicine

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Upper Limb Ischemia Due to Arterial Thrombosis after COVID-19 Vaccination

Alsmady

Al-Qaryouti

Sultan

et al. 2022

Case Reports in Medicine

View full text Add to dashboard Cite

show abstract

“…The heptapeptide resemblance between coronavirus spike glycoprotein and numerous human proteins further supports molecular mimicry as a potential mechanism behind such vaccine-induced disorders [ 41 ]. Several autoimmune conditions, including vaccine-induced thrombotic thrombocytopenia (VITT) [ 8 ] and Guillain-Barré syndrome (GBS) [ 40 ], have been reported following coronavirus vaccination. Anti-spike antibodies may potentially react with antigens anywhere along the auditory pathway and initiate an inflammatory reaction involving the tympanic membrane, ossicular chain, cochlea, cochlear vessels, organ of Corti, etc.…”

Section: Pathophysiologymentioning

confidence: 99%

“…Therefore, any potential association between vaccines and NO dysregulation should be investigated. Certain COVID-19 vaccines have been associated with vaccine-induced thrombotic thrombocytopenia [ 8 ]. Developing thrombus can reduce the blood supply to the ear and increase the probability of developing tinnitus.…”

Section: Pathophysiologymentioning

confidence: 99%

“…The adverse effects of vaccines are mostly mild and transient, commonly including pain at the injection site, pyrexia, headache, myalgias, fatigue, chills [ 5 ] and dermatologic manifestations like Pityriasis Rosea [ 6 ]. However, severe complications like anaphylaxis [ 7 ], vaccine-induced immune thrombotic thrombocytopenia [ 8 ], myocarditis [ 9 ] have also been reported. The adverse effects of vaccine are markedly outweighed by their beneficial effects, in decreasing hospital admissions and deaths due to the SARS-CoV-2 [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

SARS-CoV-2 vaccine-associated-tinnitus: A review

Ahmed

Waseem

Shaikh

et al. 2022

Annals of Medicine &Amp; Surgery

Self Cite

View full text Add to dashboard Cite

The global vaccination drive against severe acute respiratory syndrome coronavirus-2 is being pursued at a historic pace. Unexpected adverse effects have been reported following vaccination, including thrombotic thrombocytopenia, myocarditis, amongst others. More recently, some cases of tinnitus are reported post-vaccination. According to the Vaccine Adverse Events Reporting System (VAERS), 12,247 cases of coronavirus post-vaccination tinnitus have been reported till 14 th September 2021. To the best of our knowledge, this is the first review evaluating any otologic manifestation following vaccine administration and aims to evaluate the potential pathophysiology, clinical approach, and treatment. Although the incidence is infrequent, there is a need to understand the precise mechanisms and treatment for vaccine-associated-tinnitus.

show abstract

“…The current pandemic of COVID-19 has caused a drastic effect on the healthcare system and global economy, and the vaccination of COVID-19, although reducing the death rate, may cause thrombosis (which is also a complication of many other infections) [9,113]. Thrombosis has gained attention as a deadly complication of respiratory viral infections also (like influenza and coronavirus) [8].…”

Section: Thrombolytic Activitymentioning

confidence: 99%

Comprehensive Phytochemical Profiling, Biological Activities, and Molecular Docking Studies of Pleurospermum candollei: An Insight into Potential for Natural Products Development

et al. 2022

View full text Add to dashboard Cite

The purpose of this study was to find the biological propensities of the vegetable plant Pleurospermum candollei by investigating its phytochemical profile and biological activities. Phytochemical analysis was done by spectroscopic methods to investigate the amount of total polyphenols, and biological evaluation was done by the different antioxidant, enzyme inhibitory (tyrosinase, α-amylase, and α-glucosidase), thrombolytic, and antibacterial activities. The highest amount of total phenolic and flavonoid contents was observed in methanolic extract (240.69 ± 2.94 mg GAE/g and 167.59 ± 3.47 mg QE/g); the fractions showed comparatively less quantity (57.02 ± 1.31 to 144.02 ± 2.11 mg GAE/g, and 48.21 ± 0.75 to 96.58 ± 2.30 mg QE/g). The effect of these bioactive contents was also related to biological activities. GCMS analysis led to the identification of bioactive compounds with different biological effects from methanolic extract (antioxidant; 55.07%, antimicrobial; 56.41%), while the identified compounds from the n-hexane fraction with antioxidant properties constituted 67.86%, and those with antimicrobial effects constituted 82.95%; however, the synergetic effect of polyphenols may also have contributed to the highest value of biological activities of methanolic extract. Molecular docking was also performed to understand the relationship of identified secondary metabolites with enzyme-inhibitory activities. The thrombolytic activity was also significant (40.18 ± 1.80 to 57.15 ± 1.10 % clot lysis) in comparison with streptokinase (78.5 ± 1.53 to 82.34 ± 1.25% clot lysis). Methanolic extract also showed good activity against Gram-positive strains of bacteria, and the highest activity was observed against Bacillus subtilis. The findings of this study will improve our knowledge of phytochemistry, and biological activities of P. candollei, which seems to be a ray of hope to design formulations of natural products for the improvement of health and prevention of chronic diseases; however, further research may address the development of novel drugs for use in pharmaceuticals.

show abstract

Vaccine-induced thrombotic thrombocytopenia following coronavirus vaccine: A narrative review

Cited by 14 publications

References 53 publications

Upper Limb Ischemia Due to Arterial Thrombosis after COVID-19 Vaccination

Upper Limb Ischemia Due to Arterial Thrombosis after COVID-19 Vaccination

SARS-CoV-2 vaccine-associated-tinnitus: A review

Comprehensive Phytochemical Profiling, Biological Activities, and Molecular Docking Studies of Pleurospermum candollei: An Insight into Potential for Natural Products Development

Contact Info

Product

Resources

About