Vaccines for preventing influenza in people with asthma

Abstract

Analysis 1.3. Comparison 1 Protection from inactivated influenza vaccine versus placebo, Outcome 3 Severity of influenzarelated asthma exacerbation (symptom score

Beyond Respiratory Syncytial Virus and Rhinovirus in the Pathogenesis and Exacerbation of Asthma

“…The most recent Cochrane Review, in 2013, which included 18 trials across the world, concluded that inactivated influenza vaccine did not provide significant reduction in the number or duration of influenza-related asthma exacerbations. 69 Safety concern was raised in an earlier study that showed a decrease in peak flow following the administration of the inactivated influenza vaccine. 70 A subsequent study in the Netherlands 71 and a large study in the United States 72 enrolling more than 2000 patients with asthma confirmed that there is no increase in risk for adverse events including asthma exacerbation within 2 weeks following the injection.…”

“…This Cochran Review also conducted a systematic review in 3 trials comparing intranasal vaccine with intramuscular infection in infants and older children and concluded that event rates for asthma exacerbation and wheezing were similar in both vaccine types. 69 A more recent study in the United Kingdom evaluated the safety of intranasal live attenuated influenza vaccine in atopic children with well-defined allergy to eggs. Sixty-seven percent of children had asthma in addition to their egg allergies.…”

Hintergrundpapier der STIKO: Evaluation der bestehenden Influenzaimpfempfehlung für Indikationsgruppen und für Senioren (Standardimpfung ab 60 Jahren)

“…(AMSTAR-Score 8/11) verwendet, der die Wirksamkeit und Sicherheit der Influenzaimpfung bei Personen mit Asthma untersucht hat [63]. Aus diesem Review, der insgesamt 18 RCTs einschloss, wurden nur solche Originalstudien berücksichtigt, die TIV mit einer Placebogruppe verglichen.…”

Influenza and pneumococcus vaccination: current recommendations

“…In a Cochrane review, the controlled trials noted no benefit in preventing influenza-related asthma exacerbations, although vaccination might improve specific aspects of asthmarelated quality of life among children. Moreover, it has been shown that IIV is not associated with asthma exacerbations 2 weeks after vaccination in children and adults [15]. A few studies support the hypothesis that IIV vaccination might provide protection against influenza-related asthma exacerbations, but these studies were not prospective, randomized, or controlled and thus were excluded from analysis in the Cochrane review [15].…”

“…Moreover, it has been shown that IIV is not associated with asthma exacerbations 2 weeks after vaccination in children and adults [15]. A few studies support the hypothesis that IIV vaccination might provide protection against influenza-related asthma exacerbations, but these studies were not prospective, randomized, or controlled and thus were excluded from analysis in the Cochrane review [15]. A study noted that vaccination was associated with reduced oral steroid use for asthma exacerbations and a protective effect in reducing severity-adjusted asthma exacerbations by 22% to 45% [16][17][18].…”