Vagal activities are involved in antigen‐specific immune inflammation in the intestine

Liang, Hong; Xu, Lunshan; Zhou, Chun Hui; Zhang, Yihua; Xu, Minhui; Zhang, Chengqu

doi:10.1111/j.1440-1746.2011.06710.x

Cited by 12 publications

(9 citation statements)

References 16 publications

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“…They examined the IgE receptor/IgE complex on VGN in mouse models of FA, evaluating the effect of the partial removal of the vagal nerve via surgery or administration with anticholinergic agents on the suppression of Th2 inflammation. [20] The authors found a high-affinity IgE receptor on the intestinal vagus nerve and an increased expression of the IgE receptor on the vagus nerve in the intestines of mice with intestinal immune inflammation. Isolated mouse VGN expressed IgE receptor I, which could form complexes with IgE.…”

Section: Discussionmentioning

confidence: 99%

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Nervous system involvement in clinical peripheral inflammation: A description of three pediatric cases

et al. 2016

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Latest research data have emphasized the interaction between the nervous and the immune systems. In this regard, it has been demonstrated that the disruption of the blood–brain barrier (BBB) secondary to peripheral inflammation may play a key role in this relationship. This assumption is linked to recent findings according to which units that constitute the BBB are not only simply neurologic but have also been reconsidered as “neurovascular” elements, through which immune system molecules are vehiculated within the central nervous system (CNS). Herein, we report two cases of food allergy (FA) and one case of infective gastroenteritis, associated with a spectrum of neurologic disorders involving both the CNS and the peripheral nervous system (PNS), postulating some etiopathogenic hypotheses to explain the link between peripheral inflammation and diseases of the nervous system (NS). Three pediatric cases of secondary NS involvement after gastrointestinal (GI) inflammation of different nature have been reported. The first case highlights the link between FA and CNS; the second one is based on a description of a link between GI infection and CNS involvement while the third one describes the relationship between FA and PNS. The importance of these reports relies on the clinical demonstration of a link between the immune system and the NS. The relationship between immune system and NS seems to have pleiotropic aspects, involving different areas of the NS, such as CNS and PNS, which also seem to be in some way interconnected.

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Section: Discussionmentioning

confidence: 99%

“…The partial removal of the vagus nervous suppressed Th2 inflammation in the intestine. [20] Therefore, authors concluded that the mice intestinal vagus nerve expressed a high-affinity IgE receptor, underlying the relationship between enteric inflammation and activation of the parasympathetic nervous system.…”

Section: Discussionmentioning

confidence: 99%

Nervous system involvement in clinical peripheral inflammation: A description of three pediatric cases

et al. 2016

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“…As outlined in Table , dendritic cells express the receptors activated by acetylcholine and their function is regulated by cholinergic mechanisms . Experimental models in vagotomy and vagal nerve stimulation indicate that the vagal nerve induces cellular changes within dendritic cells that modulate immune tolerance in the local environment …”

Section: Cells Involved In Intestinal Autonomic Signallingmentioning

confidence: 99%

Review article: the role of the autonomic nervous system in the pathogenesis and therapy of IBD

Mogilevski

Burgell

Aziz

et al. 2019

Aliment Pharmacol Ther

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Summary Background There is a growing body of evidence implicating a role for the brain‐gut axis in the pathogenesis of inflammation in patients with IBD. Aims To perform a narrative review of published literature regarding the association of the autonomic nervous system and intestinal inflammation and to describe the rationale for and emerging use of autonomic manipulation as a therapeutic agent Methods Current relevant literature was summarised and critically examined. Results There is substantial pre‐clinical and clinical evidence for a multifaceted anti‐inflammatory effect of the vagus at both systemic and local intestinal levels. It acts via acetylcholine‐mediated activation of α‐7‐acetylcholine receptors involving multiple cell types in innate and adaptive immunity and the enteric nervous system with subsequent protective influences on the intestinal barrier, inflammatory mechanisms and the microbiome. In patients with IBD, there is evidence for a sympatho‐vagal imbalance, functional enteric neuronal depletion and hyporeactivity of the hypothalamic‐pituitary‐adrenal axis. Direct or transcutaneous vagal neuromodulation up‐regulates the cholinergic anti‐inflammatory pathway in pre‐clinical and clinical models with down‐regulation of systemic and local intestinal inflammation. This is supported by two small studies in Crohn's disease although remains to be investigated in ulcerative colitis. Conclusions Modulating the cholinergic anti‐inflammatory pathway influences inflammation both systemically and at a local intestinal level. It represents a potentially underutilised anti‐inflammatory therapeutic strategy. Given the likely pathogenic role of the autonomic nervous system in patients with IBD, vagal neuromodulation, an apparently safe and successful means of increasing vagal tone, warrants further clinical exploration.

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“…More recently, Rijnierse et al [199] found that dorsal root ganglion neurons expressed Fc RI and could specifically bind IgE and the free immunoglobulin light chain (IgLC). Application of the corresponding antigen to IgLC-or IgE-sensitized DRG neurons activated a sustained increase in intracellular Ca 2+.…”

Section: Immunoglobulin Receptor Expression By Neu-rons: a New Paradimentioning

confidence: 98%

The Nervous System as a Critical Regulator of Immune Responses Underlying Allergy

Forsythe¹

2012

CPD

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The nervous and immune systems collaborate in the control of homeostasis and host defence. All divisions of the nervous system, sympathetic, parasympathetic and sensory, act to regulate immune cell function. Processes under neuronal control include antigen processing and presentation, Th1/Th2 balance, immunoglobulin production and antigen specific responses, while involvement of the central nervous system allows for behavioral changes leading to avoidance of antigen or noxious stimuli. It therefore follows that dysregulation of these complex bidirectional neuroimmune signaling systems may contribute to the aetiology and pathophysiology of immune disorders including atopic disease. A greater understanding on how the brain perceives, processes and responds to immune challenges and how multiple neurotransmitters interact to maintain or skew the balance between tolerance and immunity will undoubtedly provide opportunities for the development of novel therapeutics. Furthermore, the implications for atopic disease of relatively recent developments such as the cholinergic anti-inflammatory pathway and the potential direct antigen-specific activation of the nervous system require further exploration.

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Vagal activities are involved in antigen‐specific immune inflammation in the intestine

Cited by 12 publications

References 16 publications

Nervous system involvement in clinical peripheral inflammation: A description of three pediatric cases

Nervous system involvement in clinical peripheral inflammation: A description of three pediatric cases

Review article: the role of the autonomic nervous system in the pathogenesis and therapy of IBD

The Nervous System as a Critical Regulator of Immune Responses Underlying Allergy

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