Vagal and sympathetic control of gastric and duodenal bicarbonate secretion

Fändriks, Lars; Jönson, C.

doi:10.1111/j.1365-2796.1990.tb01480.x

Cited by 14 publications

(6 citation statements)

References 23 publications

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“…These include vago-vagal reflexes (2,7,15,16,23), reflexes within the submucosal plexus of the enteric nervous system (12), C fiber efferent mechanisms (11,29), and inputs from the sympathetic nervous system (5,6,22). The interactions between these neural pathways have also been studied, and the findings suggest that secretomotor reflexes within the submucosal plexus are modified by vagal and sympathetic efferents that provide excitatory and inhibitory inputs, respectively, to submucosal neurons (6,22). These studies demonstrate that neural regulation of epithelial bicarbonate and mucin secretion from intestinal epithelium involves a complex interplay between extrinsic autonomic nerves and intrinsic secretomotor neurons in the submucosal plexus.…”

Section: Moore Beverley a David Kim And Stephen Vannermentioning

confidence: 99%

Neural pathways regulating Brunner's gland secretion in guinea pig duodenum in vitro

Moore

Kim

Vanner

2000

American Journal of Physiology-Gastrointestinal and Liver Physi

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This study examined the neural pathways innervating Brunner's glands using a novel in vitro model of acinar secretion from Brunner's glands in submucosal preparations from the guinea pig duodenum. Neural pathways were activated by focal electrical stimulation and excitatory agonists, and videomicroscopy was used to monitor dilation of acinar lumen. Electrical stimulation of perivascular nerves evoked large dilations that were blocked by TTX (1 microM) or the muscarinic receptor antagonist 4-diphenylacetoxy-N-(2-chloroethyl)-piperidine hydrochloride (1 microM). The nicotinic agonist 1,1-dimethyl-4-phenylpiperazinium iodide (100 microM) had no effect, and the nerve-evoked responses were not inhibited by hexamethonium (200 microM). Dilations were abolished in preparations from chronically vagotomized animals. Activation of submucosal ganglia significantly dilated submucosal arterioles but not Brunner's glands. Effects of electrical stimulation of perivascular and submucosal nerves were not altered by guanethidine. Capsaicin and substance P also dilated arterioles but had no effect on Brunner's glands. Cholinergic (choline acetyltransferase-immunoreactive) nerve fibers were found in Brunner's glands. These findings demonstrate that Brunner's glands are innervated by cholinergic vagal fibers but not by capsaicin-sensitive or intrinsic enteric nerves.

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Section: Moore Beverley a David Kim And Stephen Vannermentioning

confidence: 99%

Neural pathways regulating Brunner's gland secretion in guinea pig duodenum in vitro

Moore

Kim

Vanner

2000

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…The present results seem to be in consistent with the protective role of NO in the gastric mucosa. The HCO3 secretion in the stomach is known to increase in response to vagal excitation or agents that stimulate acid secretion (11,12). Barrachina et al (13) recently reported that L-NAME significantly reversed the antisecretory effect of endotoxin on distention-stimulated acid output and suggested the in volvement of NO in the regulation of acid secretion.…”

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confidence: 99%

Effects of Nitric Oxide Synthase Inhibitors on Gastric Alkaline Secretion in Rats.

et al. 1992

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ABSTRACT-The effects of NG-nitro-L-arginine methyl ester (L-NAME), the nitric oxide (NO) syn thase inhibitor, on gastric HC03 secretion were examined in anesthetized rats. Intravenous adminis tration of L-NAME (1, 2.5, 5 mg/kg) increased HC03 secretion in a dose-related manner. This effect of L-NAME was mimicked by NG-mono-methyl-L-arginine (50 mg/kg, i.v.) and was antagonized signifi cantly by concurrent administration of L-arginine but not D-arginine (200 mg/kg, i.v.). These results in dicate that gastric HC03 secretion is stimulated by inhibition of NO biosynthesis.Keywords: Nitric oxide synthase inhibitor, HC03 secretion, StomachNitric oxide (NO), synthesized from the semi-essen tial amino acid L-arginine by NO synthase in the vascu lar endothelium is now established to mediate various biological actions under physiological conditions (1). Recent studies have shown that NO also plays an im portant role in the modulation of the gastric mucosal integrity by interacting with other protective mediators (2, 3). Regulation of gastric mucosal blood flow is con sidered to be the major mechanism responsible for the mucosal protective action of NO (2, 4), yet the influ ences of the inhibition of NO biosynthesis on other de fensive factors such as HC03 secretion has not been studied. In the present study, we thus examined the effects of the NO synthase inhibitor on HC03 secre tion in the rat stomach using NG-nitro-L-arginine as the methyl ester (L-NAME) and characterized these effects in relation to endogenous NO.Male Sprague Dawley rats (230 250 g), kept in indi vidual cages with raised mesh bottoms, were deprived of food but allowed free access to tap water for 18 hr before the experiments. The animals were anesthetized with urethane (1.25 g/kg, i.p.; Tokyo Kasei); and then the stomach was exposed, mounted on a chamber (ex posed area: 3.14 cm2), and perfused with saline that was gassed with 100% 02. HC03 secretion was deter mined at pH 7.0 by continuous titration of the perfusate with 10 mM HCl under acid inhibition by omeprazole (60 mg/kg, i.p.). In some cases, the stomach was per fused with acidified saline (pH 4.5) at the rate of 1 ml/min, and the pH of the perfusate and transmucosal potential difference (PD) were monitored simultaneous ly with arterial blood pressure (BP). The pH was meas ured by a flow type glass electrode (Horiba, Model 6901-25T), while PD was determined by using two agar bridges, one positioned in the chamber and the other in the abdominal cavity (5). BP was monitored via the femoral artery by a pressure transducer and amplifier system (Nihon Kohden). NG-nitro-L-arginine methyl ester (L-NAME: Sigma), NG-monomethyl-L-arginine (L-NMMA: Sigma) and prostaglandin E2 (PGE2, Funa koshi) were given i.v. after basal secretion had stabi lized. In some cases, L or D-arginine (Wako) was given i.v. 5 min before administration of L-NAME. Data are presented as the mean ± S.E. from 5-6 rats. Statistical analyses were performed by the two-tailed Dunnett's multiple comparison test, and values of P < 0.05 were r...

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“…[ 10 ] Vagal stimulation along with sympathetic irritation of gastric mucosa can be attributing factor for anxiety and emotional stress. [ 11 ] Data showed that aggravating factor in 17 (57%) patients was due to diet, 5 (17%) patients due to cold climate, 4 (13%) patients due to drug intake, while 3 (10%) patients by improper posture and 1 (3%) patient had occupation as aggravating factor. Intake of spicy food, Pitta Kaphavardhaka Ahara (food which aggravated Pitta and Kapha ) Vitiates Pitta , which causes Vidagdhaajirna .…”

Section: Discussionmentioning

confidence: 99%

Clinical efficacy of Baladi Manduram in the management of Amlapitta

Kumar

Sridurga

Rao

2017

AYU

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Background:Amlapitta is a commonly encountered disease of Annavaha Srotasa (gastrointestinal system) described in various classical Ayurvedic texts. The cardinal features of Amlapitta are Avipaka (indigestion), Hritkantha Daha (heart and throat burn) and Tikta-Amlodgara (sour and bitter belching). This disease can be correlated with gastroesophageal reflux disease based on the clinical features. Baladi Manduram is one of the unique formulations mentioned in Rasa Kamadhenu indicated for the management of Amlapitta.Aims:This study is aimed to evaluate the efficacy of Baladi Manduram in the management of Amlapitta.Materials and Methods:A non-randomized, single-armed, open-labeled clinical trial was conducted in thirty patients having classical symptoms of Amlapitta, administered with 500 mg of Baladi Manduram twice a day after meals for 30 days. The assessment was done based on subjective parameters, i.e., Amlodgara (sour belching), Daha (heart burn), Gaurava (heaviness), Utklesha (nausea), Avipaka (indigestion) and Kshudha Alpata (loss of appetite). The results were statistically analyzed using the paired t-test.Results:Statistically highly significant relief (P < 0.001) was noted in Amlodgara, Hritkantha Daha, Utklesha and Agnimandya and statistically highly significant relief (P < 0.01) was seen in Gaurava and Avipaka.Conclusion:Baladi Manduram can be considered as an effective formulation in the management of Amlapitta.

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Vagal and sympathetic control of gastric and duodenal bicarbonate secretion

Cited by 14 publications

References 23 publications

Neural pathways regulating Brunner's gland secretion in guinea pig duodenum in vitro

Neural pathways regulating Brunner's gland secretion in guinea pig duodenum in vitro

Effects of Nitric Oxide Synthase Inhibitors on Gastric Alkaline Secretion in Rats.

Clinical efficacy of Baladi Manduram in the management of Amlapitta

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