Validation of in vivo 2D Displacements from Spiral Cine DENSE at 3T

Wehner, Gregory J; Suever, Jonathan D.; Haggerty, Christopher M; Jing, Linyuan; Powell, David W.; Hamlet, Sean M; Grabau, Jonathan D.; Mojsejenko, Dimitri; Zhong, Xiaodong; Epstein, Frederick H.; Fornwalt, Brandon K.

doi:10.1186/1532-429x-17-s1-q120

Cited by 5 publications

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“…We observed that myocardial strain measured using DENSE was higher at 1.5T compared with 3.0T. Looking 24 and Wehner et al 25 did not observe any differences in strain between field strengths; however, the sample size in both studies was small. The 3.0T scanner used in this study had a 70 cm bore, while the 1.5T had a 60 cm bore.…”

Section: Discussioncontrasting

confidence: 49%

Myocardial strain in healthy adults across a broad age range as revealed by cardiac magnetic resonance imaging at 1.5 and 3.0T: Associations of myocardial strain with myocardial region, age, and sex

Mangion

Clerfond

McComb

et al. 2016

Magnetic Resonance Imaging

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PurposeTo assess myocardial strain using cine displacement encoding with stimulated echoes (DENSE) using 1.5T and 3.0T MRI in healthy adults.Materials and MethodsHealthy adults without any history of cardiovascular disease underwent magnetic resonance imaging (MRI) at 1.5T and 3.0T within 2 days. The MRI protocol included balanced steady‐state free‐precession (b‐SSFP), 2D cine‐echo planar imaging (EPI)‐DENSE, and late gadolinium enhancement in subjects >45 years. Acquisitions were divided into six segments; global and segmental peak longitudinal and circumferential strain were derived and analyzed by field strength, age, and gender.ResultsIn all, 89 volunteers (mean age 44.8 ± 18.0 years, range: 18–87 years) underwent MRI at 1.5T, and 88 of these subjects underwent MRI at 3.0T (1.4 ± 1.4 days between the scans). Compared with 3.0T, the magnitudes of global circumferential (–19.5 ± 2.6% vs. –18.47 ± 2.6%; P = 0.001) and longitudinal (–12.47 ± 3.2% vs. –10.53 ± 3.1%; P = 0.004) strain were greater at 1.5T. At 1.5T, longitudinal strain was greater in females than in males: –10.17 ± 3.4% vs. –13.67 ± 2.4%; P = 0.001. Similar observations occurred for circumferential strain at 1.5T (–18.72 ± 2.2% vs. –20.10 ± 2.7%; P = 0.014) and at 3.0T (–17.92 ± 1.8% vs. –19.1 ± 3.1%; P = 0.047). At 1.5T, longitudinal and circumferential strain were not associated with age after accounting for sex (longitudinal strain P = 0.178, circumferential strain P = 0.733). At 3.0T, longitudinal and circumferential strain were associated with age (P < 0.05). Longitudinal strain values were greater in the apico‐septal, basal‐lateral, and mid‐lateral segments and circumferential strain in the inferior, infero‐lateral, and antero‐lateral LV segments.ConclusionMyocardial strain parameters as revealed by cine‐DENSE at different MRI field strengths were associated with myocardial region, age, and sex. J. Magn. Reson. Imaging 2016;44:1197–1205.

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Section: Discussioncontrasting

confidence: 49%

Myocardial strain in healthy adults across a broad age range as revealed by cardiac magnetic resonance imaging at 1.5 and 3.0T: Associations of myocardial strain with myocardial region, age, and sex

Mangion

Clerfond

McComb

et al. 2016

Magnetic Resonance Imaging

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“…All volunteer imaging was performed on 3T systems (Magnetom Trio and Magnetom Prisma, Siemens Healthcare) with a phased‐array body coil (6‐channel for Magnetom Trio and 18‐channel for Magnetom Prisma) and a 32‐channel spine coil. After the acquisition of localizer images, a mid‐ventricular short‐axis slice was acquired during both breath‐holding and free‐breathing acquisitions with the following parameters: FOV = 160 × 160 mm 2 , thickness of localized stimulated echo = 80–100 mm 2 , 6 spiral interleaves per image, 2 interleaves per heartbeat, spiral readout length of 3.4 ms, in‐plane spatial resolution of 3 × 3 mm 2 , slice thickness = 8 mm, TR = 15 ms, TE = 1.08 ms, and temporal resolution of 30 ms. Ramped flip angles with a final flip angle of 15 ° were used to achieve a consistent SNR through the cardiac cycle . Fat suppression was used by applying a fat saturation pulse immediately after ECG triggering as previously described .…”

Section: Methodsmentioning

confidence: 99%

“…The apparent SNR was measured from magnitude‐reconstructed images using a region of interest (ROI) that included all of the myocardium within a slice and a large background ROI. The apparent SNR was calculated as the mean of the myocardial ROI divided by the standard deviation of the background ROI, and the correction for the Rician distribution of the magnitude signal was applied . In addition, phase quality (the variance of the local 2D spatial derivative of the phase image) was measured from all of the manually segmented myocardium within each slice.…”

Section: Methodsmentioning

confidence: 99%

“…The apparent SNR was calculated as the mean of the myocardial ROI divided by the standard deviation of the background ROI, and the correction for the Rician distribution of the magnitude signal was applied. 27,31 In addition, phase quality (the variance of the local 2D spatial derivative of the phase image) 32,33 was measured from all of the manually segmented myocardium within each slice. Phase quality was calculated for background phase-corrected phase images after phase unwrapping.…”

Section: Comparison Of the Match-making Framework With The Conventimentioning

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Free‐breathing cine DENSE MRI using phase cycling with matchmaking and stimulated‐echo image‐based navigators

Cai

Epstein

2018

Magnetic Resonance in Med

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“…Here, we focus on methods applied to full-field measures, 5 where either strains or displacements due to known applied loads are measured on the surface or the boundaries of the domain of interest and also in its interior. For example, using magnetic resonance imaging (MRI), the heart's displacement field due to the filling pressure can be measured at many hundreds of homogeneously spaced locations (eg, 2 × 2 mm in plane resolution) inside the myocardial wall (see, eg, studies [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Method for the unique identification of hyperelastic material properties using full‐field measures. Application to the passive myocardium material response

Perotti

Ponnaluri

Krishnamoorthi

et al. 2017

Numer Methods Biomed Eng

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Summary Quantitative measurement of the material properties (e.g., stiffness) of biological tissues is poised to become a powerful diagnostic tool. There are currently several methods in the literature to estimating material stiffness and we extend this work by formulating a framework that leads to uniquely identified material properties. We design an approach to work with full field displacement data — i.e., we assume the displacement field due to the applied forces is known both on the boundaries and also within the interior of the body of interest — and seek stiffness parameters that lead to balanced internal and external forces in a model. For in vivo applications, the displacement data can be acquired clinically using magnetic resonance imaging while the forces may be computed from pressure measurements, e.g., through catheterization. We outline a set of conditions under which the least-square force error objective function is convex, yielding uniquely identified material properties. An important component of our framework is a new numerical strategy to formulate polyconvex material energy laws that are linear in the material properties and provide one optimal description of the available experimental data. An outcome of our approach is the analysis of the reliability of the identified material properties, even for material laws that do not admit unique property identification. Lastly, we evaluate our approach using passive myocardium experimental data at the material point and show its application to identifying myocardial stiffness with an in silico experiment modeling the passive filling of the left ventricle.

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Validation of in vivo 2D Displacements from Spiral Cine DENSE at 3T

Cited by 5 publications

References 0 publications

Myocardial strain in healthy adults across a broad age range as revealed by cardiac magnetic resonance imaging at 1.5 and 3.0T: Associations of myocardial strain with myocardial region, age, and sex

Myocardial strain in healthy adults across a broad age range as revealed by cardiac magnetic resonance imaging at 1.5 and 3.0T: Associations of myocardial strain with myocardial region, age, and sex

Free‐breathing cine DENSE MRI using phase cycling with matchmaking and stimulated‐echo image‐based navigators

Method for the unique identification of hyperelastic material properties using full‐field measures. Application to the passive myocardium material response

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