Validation of liquid chromatographic method for analysis of lidocaine hydrochloride, dexamethasone acetate, calcium dobesilate, buthylhydroxyanisol and degradation product hydroquinone in suppositories and ointment

Development and validation of rp-hplc method for simultaneous determination of granisetron and dexametazhasone

“…As a prerequisite to the development of combined dosage form of GRA and DEX, a robust analytical method would be required, which would be applicable not only for assay purpose but also for drug release studies from different dosage forms. Literature survey revealed UV/Vis spectrophotometric and HPLC methods for the determination of DEX[7–9] and GRA[10–11] individually. No method has been reported in the literature for simultaneous estimation of GRA and DEX.…”

Simultaneous determination of arbutin and its decomposed product hydroquinone in whitening creams using high‐performance liquid chromatography with photodiode array detection: Effect of temperature and pH on decomposition

“…The LOQ obtained in this study for arbutin is comparatively lower than the values previously reported by Masse et al [6] (1.85 lg mL À1 ), Desmedt et al [15] (0.056 lg mL À1 ), Huang et al [16] (3.33 lg mL À1 ), Thongchai et al [17] (0.0101 lg mL À1 ) and Jeon et al [18] (0.75 lg mL À1 ). Furthermore, the reported LOQ for hydroquinone was lower than that recorded by Desmedt et al [15] (0.898 lg mL À1 ), Huang et al [16] (1.66 lg mL À1 ), Gao and Legido-Quigley [26] (0.66 lg mL À1 ) and Zivanovic et al [27] (0.04 lg mL À1 ). The recovery rates of arbutin and hydroquinone ranged from 101.7% to 102.6% and 90.0% to 90.2%, respectively (Table III).…”

Simultaneous determination of water‐soluble whitening ingredients and adenosine in different cosmetic formulations by high‐performance liquid chromatography coupled with photodiode array detection

“…High-performance liquid chromatography (HPLC) is a general technique for the quantitative estimation of arbutin in whitening cosmetics [10,14,[25][26][27][28][29][30] and hydroquinone in cosmetic creams, topical dermatologic drugs and other matrices [27,[30][31][32][33][34][35]. Previously, arbutin, niacinamide and adenosine have been simultaneously determined in cosmetic products by HPLC [29].…”