Validation of the European Society of Urogenital Radiology Scoring System for Prostate Cancer Diagnosis on Multiparametric Magnetic Resonance Imaging in a Cohort of Repeat Biopsy Patients

Portalez, D.; Mozer, Pierre; Cornud, F.; Renard-Penna, R.; Misraï, Vincent; Thoulouzan, M.; Malavaud, Bernard

doi:10.1016/j.eururo.2012.06.044

Cited by 176 publications

(93 citation statements)

References 31 publications

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“…6 Nicht-parametrische receiver operating characteristic (ROC) curves mit den entsprechenden areas under the curve (AUC) der Reader 1 -3 für highrisk-, low-risk-und alle Prostatakarzinome. showed a considerable improvement of sensitivity and diagnostic accuracy [7,13,16,18]. We found good interobserver agreement for the detection of high-grade prostate cancers by MRI, suggesting that our results are reproducible in this clinical setting.…”

Section: Figsupporting

confidence: 53%

Role of Endorectal Prostate MRI in Patients with Initial Suspicion of Prostate Cancer

Franiel

Vargas

Mazaheri

et al. 2013

Fortschr Röntgenstr

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Purpose: To evaluate the role of conventional endorectal prostate MRI in patients with initial suspicion of prostate cancer. Materials and Methods: Ethics board approval was received for this retrospective study of 87?men who underwent 1.5-Tesla conventional prostate MRI with a combination of endorectal and body phased-array coils for suspected prostate cancer before their first systematic 12-core TRUS-guided biopsy. Three radiologists independently analyzed the images, dividing the prostate into 12 regions corresponding to the biopsy scheme and scoring each region for the presence of prostate cancer on a 5-point scale. Results were analyzed by prostate region. ROC analysis was done and descriptive statistics were calculated. The negative predictive value, specificity, sensitivity and positive predictive value were calculated using dichotomized scores (benign tissue?= scores of 1 and 2; malignant tissues?=?scores of 3, 4, and 5). Results: Biopsy revealed cancer in 47/87 patients (26 low-grade [Gleason score 6]; 21 high-grade [Gleason score ??3?+?4]), and 184/1044 cores (77?low-grade and 107 high-grade) with a median of 3 positive cores per cancer patient (range 1???12). The areas under ROC curves were 0.65???0.67 for cancer detection by region overall and 0.75???0.76 for the detection of high-grade cancer by region. Statistic figures for the detection of all cancers/high-grade cancers by region were as follows: negative predictive value, 87.4???88.2?%/92.6???93.1?%; specificity, 72.3???79.4?%/71.5???79.8?%; sensitivity, 49.5???54.8?%/62.6???69.2?%; and positive predictive value, 29.3???34.0?%/29.4???34.7?%. Conclusion: In patients with suspected prostate cancer, negative MRI findings indicate the absence of high-grade prostate cancer on subsequent TRUS-guided 12-core biopsy with high probability. However, agreement between conventional 1.5-T endorectal prostate MRI and systematic 12-core TRUS-guided biopsy for the detection of prostate cancer appears to be moderate. Citation Format:

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Section: Figsupporting

confidence: 53%

Role of Endorectal Prostate MRI in Patients with Initial Suspicion of Prostate Cancer

Franiel

Vargas

Mazaheri

et al. 2013

Fortschr Röntgenstr

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“…These data are in contrast to our findings, demonstrating an incremental value of 16% using mpMRI for PCa diagnosis. In particular, the estimation of a risk profile for men using the PI-RADS scoring system is of considerable interest as a PI-RADS score of 1 or 2 can rule out significant disease [12]. Furthermore, a stratification of risk seems to raise the overall detection rates for PCa [12], and our data also underline the usefulness of this approach as 84% of all highly suspicious lesions of the PZ were found to be PCa-positive.…”

Section: Discussionmentioning

confidence: 60%

“…In particular, the estimation of a risk profile for men using the PI-RADS scoring system is of considerable interest as a PI-RADS score of 1 or 2 can rule out significant disease [12]. Furthermore, a stratification of risk seems to raise the overall detection rates for PCa [12], and our data also underline the usefulness of this approach as 84% of all highly suspicious lesions of the PZ were found to be PCa-positive. Nevertheless, the interpretation and scoring of TZ findings seems to be the most difficult challenge in view of the sensitivity of only 32% in this study.…”

Section: Discussionmentioning

confidence: 60%

Multiparametric Magnetic Resonance Imaging/Transrectal Ultrasound Fusion Targeted Biopsy of the Prostate: Preliminary Results of a Prospective Single-Centre Study

Junker

Schäfer²,

Heidegger³

et al. 2015

Urol Int

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Purpose: To evaluate multiparametric magnetic resonance imaging/transrectal ultrasound (mpMRI/TRUS) fusion targeted biopsy (TB) of the prostate for prostate cancer (PCa) diagnosis. Patients and Methods: From April 2013 to January 2014, 53 men were included in this prospective single-centre study. The degree of PCa suspicion from mpMRI findings was classified according to the PI-RADS scoring system. Of these, 50 patients underwent both an mpMRI/TRUS fusion TB and a 10-core systematic biopsy (SB) of the prostate and were eligible for analysis. Results: 225 targeted and 500 systematic cores were included in this study. PCa was histologically confirmed in 52.0% of patients (26/50), whereas TB revealed PCa in 46.0% (23/50) and SB in 36.0% (18/50). TB identified PCa in 16.0% of all patients (8/50) that were missed by SB. All told, the targeted core was 2.8 times more likely to be PCa-positive than the systematic core (29.3 vs. 10.4%). Conclusions: mpMRI/TRUS fusion TB of the prostate is safe, practicable and may improve PCa diagnosis using fewer biopsy cores compared to SB.

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“…In a study of 64 patients with 95 regions suspected to be cancer, Roethke et al (24) demonstrated an area under the ROC curve of 0.817 for T2-weighted imaging, 0.768 for DWI, and 0.758 for DCE imaging, with US/ MR imaging-fusion guided biopsy as a reference standard. For all sequences combined, Portalez et al (25) showed an area under the ROC curve of 0.86 for the PI-RADS in 129 patients who were referred for repeat biopsies with fusionguided biopsy as the reference standard. Junker et al (4) found an area under the ROC curve of 0.97 for all sequences combined in the PZ in 50 patients, with whole-mount prostatectomy as a reference standard.…”

Section: Discussionmentioning

confidence: 99%

Prostate Cancer: Interobserver Agreement and Accuracy with the Revised Prostate Imaging Reporting and Data System at Multiparametric MR Imaging

Muller¹,

Shih²,

Sankineni³

et al. 2015

Radiology

312

198

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).q RSNA, 2015 Purpose:To evaluate accuracy and interobserver variability with the use of the Prostate Imaging Reporting and Data System (PI-RADS) version 2.0 for detection of prostate cancer at multiparametric magnetic resonance (MR) imaging in a biopsy-naïve patient population. Materials and Methods:This retrospective HIPAA-compliant study was approved by the local ethics committee, and written informed consent was obtained from all patients for use of their imaging and histopathologic data in future research studies. In 101 biopsy-naïve patients with elevated prostate-specific antigen levels who underwent multiparametric MR imaging of the prostate and subsequent transrectal ultrasonography (US)-MR imaging fusion-guided biopsy, suspicious lesions detected at multiparametric MR imaging were scored by five readers who were blinded to pathologic results by using to the newly revised PI-RADS and the scoring system developed in-house. Interobserver agreement was evaluated by using k statistics, and the correlation of pathologic results with each of the two scoring systems was evaluated by using the Kendall t correlation coefficient. Results:Specimens of 162 lesions in 94 patients were sampled by means of transrectal US-MR imaging fusion biopsy. Results for 87 (54%) lesions were positive for prostate cancer.Kendall t values with the PI-RADS and the in-house-developed scoring system, respectively, at T2-weighted MR imaging in the peripheral zone were 0.51 and 0.17 and in the transitional zone, 0.45 and 20.11; at diffusion-weighted MR imaging, 0.42 and 0.28; at dynamic contrast materialenhanced MR imaging, 0.23 and 0.24, and overall suspicion scores were 0.42 and 0.49. Median k scores among all possible pairs of readers for PI-RADS and the in-house-developed scoring system, respectively, for T2-weighted MR images in the peripheral zone were 0.47 and 0.15; transitional zone, 0.37 and 0.07; diffusion-weighted MR imaging, 0.41 and 0.57; dynamic contrast-enhanced MR imaging, 0.48 and 0.41; and overall suspicion scores, 0.46 and 0.55. Conclusion:Use of the revised PI-RADS provides moderately reproducible MR imaging scores for detection of clinically relevant disease.q RSNA, 2015

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Validation of the European Society of Urogenital Radiology Scoring System for Prostate Cancer Diagnosis on Multiparametric Magnetic Resonance Imaging in a Cohort of Repeat Biopsy Patients

Cited by 176 publications

References 31 publications

Role of Endorectal Prostate MRI in Patients with Initial Suspicion of Prostate Cancer

Role of Endorectal Prostate MRI in Patients with Initial Suspicion of Prostate Cancer

Multiparametric Magnetic Resonance Imaging/Transrectal Ultrasound Fusion Targeted Biopsy of the Prostate: Preliminary Results of a Prospective Single-Centre Study

Prostate Cancer: Interobserver Agreement and Accuracy with the Revised Prostate Imaging Reporting and Data System at Multiparametric MR Imaging

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