Validity of procalcitonin for the diagnosis of bacterial infection in elderly patients

Neutrophil CD64 Index as a superior biomarker for early diagnosis of infection in febrile patients in the hematology department

“…Analysis of clinical data and laboratory characteristics between infected and non-infected patients were performed, and it was found that the two group patients' age and sex showed no significant difference. However, the body temperature in the infection patients' group was higher: 38.8 (38.6-39.1) °C vs. 38.6 (38.5-38.8) °C (p < 0.05), and WBC Previously, four biomarkers including the neutrophil CD64 Index, PCT, IL-6 and CRP were used for clinical diagnosis of early infection [6][7][8][9][10]. Their application in febrile patients of the hematology department was investigated and it was found that all of them were higher in infection patients than those in the non-infection patients' (p < 0.001, Figure 1).…”

“…Therefore, biomarkers that may facilitate early diagnosis and the assessment of therapeutic responses have been widely explored. Cumulative published evidence supports the use of C-reactive protein (CRP), procalcitonin (PCT) measurement, while the intensity of expression of the high affinity immunoglobulin-Fc fragment receptor I (FcγRI) CD64 on neutrophile, and Interleukin-6 (IL-6) are also of potential interest [3,[6][7][8][9][10][11].…”

Procalcitonin is not an independent predictor of 30-day mortality, albeit predicts pneumonia severity in patients with pneumonia acquired outside the hospital

“…Therefore, the clinical significance of PCT as diagnostic and prognostic factors in elderly patients is an important issue. While some investigators reported usefulness of PCT for diagnosing bacterial infection in the elderly [8, 11, 47], others revealed that PCT was inferior to CRP for predicting bacterial infection in these population [9, 48, 49]. As for predicting capacity for clinical course, Shi et al reported that there were no differences in PCT between the improved and not-improved subjects in nosocomial pneumonia in the elderly [50].…”

Pancreatic stone protein and soluble CD25 for infection and sepsis in an emergency department

“…Procalcitonin is widely reported as a useful biomarker to identify bacterial infection [29,30], including in elderly [31] and immunocompromised patients [32], to differentiate sepsis from other noninfectious causes of SIRS [16] and to assess the sepsis severity [33]. Its measurement is included in some guidelines and may be considered in patients with acute heart failure with suspected coexisting infection, particularly for the differential diagnosis of pneumonia [34], and for the management of adult lower respiratory tract infections [35].…”